Click here to switch to the map view.

The map label for this gene is uhpC [H]

Identifier: 157368383

GI number: 157368383

Start: 143303

End: 144634

Strand: Direct

Name: uhpC [H]

Synonym: Spro_0134

Alternate gene names: 157368383

Gene position: 143303-144634 (Clockwise)

Preceding gene: 157368382

Following gene: 157368386

Centisome position: 2.63

GC content: 55.48

Gene sequence:

>1332_bases
ATGTGGTCTTTCCTTAAAAGCCGCGATGATGTGCCGCCGGTTACCGATCAAAAACAGATCGATGCCAGCTATAAATACTG
GCGCATCCAGCTGATGTGGACGATGTACATCGGCTATGCCGCGTTTTACTTCACGCGCAAAAGCTTCAACTTCATTATGC
CGGCAATGCTGAGCGATCTTGGCCTGACGATGTCCGACGTCGGTATTCTCGGTACGCTGTTCTACATCACTTACGGCTGC
TCGAAGTTTATTTCAGGCATGATCAGCGATCGTTCCAACCCGCGCTATTTTATGGGGTTGGGCCTGATTATGACCGGCAT
ACTCAATATCTTCTTCGGTCTCAGTTCTTCGCTGCTGATGCTGGGGACGTTGTGGATCCTCAACGCCTTCTTCCAGGGCT
GGGGTTGGCCGCCATGTTCGAAAATCCTCACAAGCTGGTACTCGCGCTCCGAGCGCGGTAGCTGGTGGGCGATCTGGAAT
ACTTCGCACAACTTTGGCGGTGCGTTAATCCCGCTGCTGGTCGGCTTTATCTCGCTGCACTTTAGCTGGCGCTACGGCAT
GATTATTCCGGGTATTATCGGCGTGGTGTTGGGCCTGCTGATGTGCTGGCGCCTGCGTGACAAGCCGTCCACCATGGGGC
TGCCCAGCGTGGGTAAATGGCGTAACGATGCCATGGAACTGGTGCAGGAATCGGAAGGTCAGGGGCTGACCAACCGCGAA
ATCATCAAGCGCTACGTGTTGACCAACAAATACATTTGGCTGCTGGCGGTGTCTTACGTGCTGGTGTACATCGTGCGTAC
GGCCATCAATGACTGGGGTAACCTGTATCTGACCCAGGAGAAAGGCTATTCGCTGATGACCGCCAACTCGGCGATATCCT
TGTTCGAAGTGGGTGGCTTTATCGGCTCGCTGGTGGCCGGTTGGGGTTCTGACAAACTGTTCCGCGGTAACCGTGGGCCA
ATGAACCTGATCTTCGCCATCGGCATCTTCCTGTCGGTTGCGGCGCTGTGGATCATGCCGGGTGTTACTTTCCTGCTGCA
GGCGGCCTGCTTCTTTGCTATCGGCTTCTTTATCTTTGGTCCGCAGATGCTGATCGGCATGGCAGCGGCGGAATGTTCGC
ACAAGGATGCTGCCGGGGCGGCAACCGGCTTTGTCGGCCTGTTTGCTTATCTGGGGGCGGCGTTGTCCGGTTACCCGATT
GCCCGCATCATGGAAATCTGGCACTGGAATGGTTTCTTCGTGGTGATCTCGATCGCTGCCTGTTTGTCCGCGCTGTTCCT
GCTGCCGTTTTTACGCGCCCAATCACCGGCGCTGAAAACTGCCAAGGCATGA

Upstream 100 bases:

>100_bases
AACTAGGAAATACTCCTAGCCGCGTCGGGAATCCGGCGTAAGTCATTTTCGCGCGCGCGCAGCATGATAGCGGCACTTTT
CATATTCTCTGAGGTTTCAC

Downstream 100 bases:

>100_bases
TGAAAAAGCGCGCTGTGGGCTGCTGTAGCGCGCTTTATGCCGCTTTTATCACCACTTGATTGACCGGGACGAGAAAGTGA
TTGACGCGAAATATCGTCAG

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MWSFLKSRDDVPPVTDQKQIDASYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLSDLGLTMSDVGILGTLFYITYGC
SKFISGMISDRSNPRYFMGLGLIMTGILNIFFGLSSSLLMLGTLWILNAFFQGWGWPPCSKILTSWYSRSERGSWWAIWN
TSHNFGGALIPLLVGFISLHFSWRYGMIIPGIIGVVLGLLMCWRLRDKPSTMGLPSVGKWRNDAMELVQESEGQGLTNRE
IIKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLMTANSAISLFEVGGFIGSLVAGWGSDKLFRGNRGP
MNLIFAIGIFLSVAALWIMPGVTFLLQAACFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISIAACLSALFLLPFLRAQSPALKTAKA

Sequences:

>Translated_443_residues
MWSFLKSRDDVPPVTDQKQIDASYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLSDLGLTMSDVGILGTLFYITYGC
SKFISGMISDRSNPRYFMGLGLIMTGILNIFFGLSSSLLMLGTLWILNAFFQGWGWPPCSKILTSWYSRSERGSWWAIWN
TSHNFGGALIPLLVGFISLHFSWRYGMIIPGIIGVVLGLLMCWRLRDKPSTMGLPSVGKWRNDAMELVQESEGQGLTNRE
IIKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLMTANSAISLFEVGGFIGSLVAGWGSDKLFRGNRGP
MNLIFAIGIFLSVAALWIMPGVTFLLQAACFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISIAACLSALFLLPFLRAQSPALKTAKA
>Mature_443_residues
MWSFLKSRDDVPPVTDQKQIDASYKYWRIQLMWTMYIGYAAFYFTRKSFNFIMPAMLSDLGLTMSDVGILGTLFYITYGC
SKFISGMISDRSNPRYFMGLGLIMTGILNIFFGLSSSLLMLGTLWILNAFFQGWGWPPCSKILTSWYSRSERGSWWAIWN
TSHNFGGALIPLLVGFISLHFSWRYGMIIPGIIGVVLGLLMCWRLRDKPSTMGLPSVGKWRNDAMELVQESEGQGLTNRE
IIKRYVLTNKYIWLLAVSYVLVYIVRTAINDWGNLYLTQEKGYSLMTANSAISLFEVGGFIGSLVAGWGSDKLFRGNRGP
MNLIFAIGIFLSVAALWIMPGVTFLLQAACFFAIGFFIFGPQMLIGMAAAECSHKDAAGAATGFVGLFAYLGAALSGYPI
ARIMEIWHWNGFFVVISIAACLSALFLLPFLRAQSPALKTAKA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=428, Percent_Identity=34.8130841121495, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4503847, Length=428, Percent_Identity=34.8130841121495, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI256219483, Length=428, Percent_Identity=34.8130841121495, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI256219543, Length=450, Percent_Identity=33.5555555555556, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI256219564, Length=359, Percent_Identity=34.5403899721448, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI46361976, Length=399, Percent_Identity=22.0551378446115, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI223717983, Length=419, Percent_Identity=25.2983293556086, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38093649, Length=419, Percent_Identity=25.2983293556086, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI14150047, Length=178, Percent_Identity=24.7191011235955, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082310, Length=436, Percent_Identity=64.6788990825688, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1788573, Length=416, Percent_Identity=37.0192307692308, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI2367259, Length=421, Percent_Identity=33.9667458432304, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI2367379, Length=453, Percent_Identity=23.6203090507726, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082320, Length=290, Percent_Identity=22.7586206896552, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789152, Length=443, Percent_Identity=23.0248306997743, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561094, Length=424, Percent_Identity=23.5849056603774, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17542316, Length=462, Percent_Identity=22.7272727272727, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI133930953, Length=453, Percent_Identity=24.0618101545254, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI133901856, Length=445, Percent_Identity=21.7977528089888, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI133901854, Length=445, Percent_Identity=21.7977528089888, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17539138, Length=317, Percent_Identity=23.6593059936909, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24656861, Length=472, Percent_Identity=22.8813559322034, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656866, Length=472, Percent_Identity=22.8813559322034, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550478, Length=472, Percent_Identity=22.8813559322034, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49465; Mature: 49465

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]