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The map label for this gene is degA [H]

Identifier: 157368369

GI number: 157368369

Start: 128119

End: 129174

Strand: Reverse

Name: degA [H]

Synonym: Spro_0120

Alternate gene names: 157368369

Gene position: 129174-128119 (Counterclockwise)

Preceding gene: 157368370

Following gene: 157368368

Centisome position: 2.37

GC content: 60.7

Gene sequence:

>1056_bases
ATGCAAAACGGGAATGTAATGGCGAATATACGTGATGTGGCACGTCATGCCGGAGTGTCGGTCAGTACGGTTTCCAACGT
GCTGAACGGCCGGGTCGATCAGATGCGCAAGGATACGCTGGCCCGTATCGAACAGGCGATGGCGGCGCTGCAGTACCAAC
CGAACCGTGCGGCGCAGCAGCTCAAAACCGGGCAGGTCAAAATGCTTGGCCTGCTGGTGCCTTCGATCGTCAACCCCAGC
TTCGCCGCACTGGTACGTGAGATTGAGCTGGCGGCCAAGCAAAACTACGGCTATCAGGTGTTGCTGGGCGATACCCATCG
CCAGCAGGAAGAGGAGATCCGCTTTCTCGACGATTTGCTGGCGTTAGGCATCCGCGGCGTGGTGGTGGCCTCCACCTTTT
ACGATCGCCCCCATTTCCGTGAGGCCCTGAAACGCGGCCTGGTGATGATTAACTACGACGAACGTGCCCTGACGGCCCCA
GGTGAAACGGCGCTGCCGATCGACAGCGTGTCGATGGACAATGGCGCCGCTGGCAACATGGCGGCCCGGCATCTGATCGC
CCAGGGCTGTCGCCGTATCGCTTTCGCCACCGCCTCCGGCATGACCAGCAGCCGCGCCAACAAGATTGCCGGCTACCGGC
AGGCACTGGAGGCGGCCGGGCTGCCGGTCAGGGTGATCGAAGGCAAAGCGCAGTTCGCCTACGGCGATGCCGAAATGGCC
GAACTGGGGAAAACGCTGGCTGAGCAGATCTGCCAGAGTGAACCCCGGCCGGACGGCGTGGTAGCGCTGAACGACATGCT
GGCCATCGGCATGATTTCCGCCTTCCAGCGGCTCGGTGTGCGGGTGCCGGAGGATATCTCGGTTGTCGGCATCGATAACA
TGTTTCTGTCCGAACTGTTCAACCCGACGCTCAGTTCTGTGGCGCCACCGCTGCGTGAGATGGCGGTAAAAATTGTCGAT
CGGCTGATCGGCCGGTTAGAAAATCCTGAACTGCCGGTGGAGGAGTTTTTATTTGCTCCCAGCCTGGTGTGCCGCCAGTC
GGTCATTAACGCGTAA

Upstream 100 bases:

>100_bases
ACATCACCGGGCAGATTATCGACGTCAACGGCGGGCAGATTGCGCCCTAAGGGTCTGTGACTCACTTTCGGCCGCGTGAT
AAAGTCAGGGTAATGGGCTA

Downstream 100 bases:

>100_bases
TCCCCGGCGGGGTCGCTGCCCCGCCCTCATTCACATGAAATTCCTGGCTGCGCTGAGGCGCGGCGGGGTTTCGCTGCGCC
CAAATCGCAGCAGGAGATTA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MQNGNVMANIRDVARHAGVSVSTVSNVLNGRVDQMRKDTLARIEQAMAALQYQPNRAAQQLKTGQVKMLGLLVPSIVNPS
FAALVREIELAAKQNYGYQVLLGDTHRQQEEEIRFLDDLLALGIRGVVVASTFYDRPHFREALKRGLVMINYDERALTAP
GETALPIDSVSMDNGAAGNMAARHLIAQGCRRIAFATASGMTSSRANKIAGYRQALEAAGLPVRVIEGKAQFAYGDAEMA
ELGKTLAEQICQSEPRPDGVVALNDMLAIGMISAFQRLGVRVPEDISVVGIDNMFLSELFNPTLSSVAPPLREMAVKIVD
RLIGRLENPELPVEEFLFAPSLVCRQSVINA

Sequences:

>Translated_351_residues
MQNGNVMANIRDVARHAGVSVSTVSNVLNGRVDQMRKDTLARIEQAMAALQYQPNRAAQQLKTGQVKMLGLLVPSIVNPS
FAALVREIELAAKQNYGYQVLLGDTHRQQEEEIRFLDDLLALGIRGVVVASTFYDRPHFREALKRGLVMINYDERALTAP
GETALPIDSVSMDNGAAGNMAARHLIAQGCRRIAFATASGMTSSRANKIAGYRQALEAAGLPVRVIEGKAQFAYGDAEMA
ELGKTLAEQICQSEPRPDGVVALNDMLAIGMISAFQRLGVRVPEDISVVGIDNMFLSELFNPTLSSVAPPLREMAVKIVD
RLIGRLENPELPVEEFLFAPSLVCRQSVINA
>Mature_351_residues
MQNGNVMANIRDVARHAGVSVSTVSNVLNGRVDQMRKDTLARIEQAMAALQYQPNRAAQQLKTGQVKMLGLLVPSIVNPS
FAALVREIELAAKQNYGYQVLLGDTHRQQEEEIRFLDDLLALGIRGVVVASTFYDRPHFREALKRGLVMINYDERALTAP
GETALPIDSVSMDNGAAGNMAARHLIAQGCRRIAFATASGMTSSRANKIAGYRQALEAAGLPVRVIEGKAQFAYGDAEMA
ELGKTLAEQICQSEPRPDGVVALNDMLAIGMISAFQRLGVRVPEDISVVGIDNMFLSELFNPTLSSVAPPLREMAVKIVD
RLIGRLENPELPVEEFLFAPSLVCRQSVINA

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=352, Percent_Identity=30.6818181818182, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789202, Length=350, Percent_Identity=29.7142857142857, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1787948, Length=350, Percent_Identity=29.1428571428571, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788474, Length=350, Percent_Identity=31.1428571428571, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1790369, Length=330, Percent_Identity=29.6969696969697, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1789068, Length=354, Percent_Identity=30.5084745762712, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994940, Length=321, Percent_Identity=30.5295950155763, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=27.9883381924198, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787906, Length=353, Percent_Identity=26.0623229461756, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786268, Length=326, Percent_Identity=25.4601226993865, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787580, Length=332, Percent_Identity=25.3012048192771, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790715, Length=328, Percent_Identity=23.780487804878, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38186; Mature: 38186

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNGNVMANIRDVARHAGVSVSTVSNVLNGRVDQMRKDTLARIEQAMAALQYQPNRAAQQ
CCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LKTGQVKMLGLLVPSIVNPSFAALVREIELAAKQNYGYQVLLGDTHRQQEEEIRFLDDLL
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
ALGIRGVVVASTFYDRPHFREALKRGLVMINYDERALTAPGETALPIDSVSMDNGAAGNM
HHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCHHH
AARHLIAQGCRRIAFATASGMTSSRANKIAGYRQALEAAGLPVRVIEGKAQFAYGDAEMA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHH
ELGKTLAEQICQSEPRPDGVVALNDMLAIGMISAFQRLGVRVPEDISVVGIDNMFLSELF
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
NPTLSSVAPPLREMAVKIVDRLIGRLENPELPVEEFLFAPSLVCRQSVINA
CHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNGNVMANIRDVARHAGVSVSTVSNVLNGRVDQMRKDTLARIEQAMAALQYQPNRAAQQ
CCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LKTGQVKMLGLLVPSIVNPSFAALVREIELAAKQNYGYQVLLGDTHRQQEEEIRFLDDLL
HHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
ALGIRGVVVASTFYDRPHFREALKRGLVMINYDERALTAPGETALPIDSVSMDNGAAGNM
HHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCEECCCCCCCCCCCCCCCCCCCCHHH
AARHLIAQGCRRIAFATASGMTSSRANKIAGYRQALEAAGLPVRVIEGKAQFAYGDAEMA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHH
ELGKTLAEQICQSEPRPDGVVALNDMLAIGMISAFQRLGVRVPEDISVVGIDNMFLSELF
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHH
NPTLSSVAPPLREMAVKIVDRLIGRLENPELPVEEFLFAPSLVCRQSVINA
CHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]