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The map label for this gene is gyaR [H]

Identifier: 157368289

GI number: 157368289

Start: 40999

End: 41946

Strand: Direct

Name: gyaR [H]

Synonym: Spro_0040

Alternate gene names: 157368289

Gene position: 40999-41946 (Clockwise)

Preceding gene: 157368288

Following gene: 157368290

Centisome position: 0.75

GC content: 59.92

Gene sequence:

>948_bases
ATGGCTGAGACCATTTTGCAGGCCTCACCTTTGCCGCAAAGGTTGGTGGTGCAACTGCGTCAACATTTCCCATTGGTGGA
TCAGCGCGAATTGGCCCCTTTGGCGCTGGCGGCCCGAGCCAGCGAATTCACCGTCCTGCTGGTTGATGGCGAAACGGCGG
TCAGTGCGGCACAAATTGCCGCTTTGCCGCAGTTAAAACTGATTGCCGTATTTGGTGTGGGCTACGAGCGGGTGGATGTG
TTGGCCGCACGGGCTCAGGGTGTGCGCGTCACGCATACGCCGGGGGTGCTGACCGATGACGTTGCCGATCTGGCGATCGG
GCTGCTGCTGGCGACGGCCAGGCAGATTGGCGGCGCCCAACGTTTTATCGAGCGCGGTGACTGGCTGCAGGGCGGCTATC
CCTGGACGCGCAAGGTTAGCGGCGCACGCCTGGGCATTCTTGGATTGGGAAGGATCGGACGGGCGATAGCTCAGCGGGCA
ACCGCCTTCAATATGGCCGTCAGTTATCATTCCCGCCAACAATATGACGATTTTAGCGGGCGTTTTTTTGCGACCCCTCA
GGCACTGGCCGAGCACTGCGACTTTCTGTTGGTTTGCACCAACGGAGGGGTGGCGACGCGGGCGCTGGTGGATGCAAAGG
TGTTAGCGGCATTGGGCGCTAACGGCATCTTAATCAACATTGCGCGAGGTTCGGTGGTCGACGAAACGGCATTAGTAAAG
GCGATTGACCAGGGAGTAATTGCCGGTGCTGGTCTGGATGTTTTTGAATGCGAACCGCAGGTTCCCGCCGGGTTGATGGG
GCGGGACAATGTGGTACTAACGCCGCATATGGCCAGCGCGACCCACAGCACGCGGCGGATGATGGCCGATCTGGTGTTCG
ACAACATAGCCGCTTATTTTGCCGGTCGGGCTTTGCCAACGCCGGTAGCGGAAAGCCCCAACCCGTAG

Upstream 100 bases:

>100_bases
GCCATCGCTGCGGCGTTGGTGGCTGGCGGCATTATCGGCCTGCGGCTTGGCAGGCCGCTATCAGCGGCCACAGGCGAGGT
TGCACTGCGGGAGAACAACC

Downstream 100 bases:

>100_bases
TGGCATTGCCTCTGTTTCCAGCCTGTTTATCGCCCAACAACGGTGGTCTGTTTTGGTACGTCACGCAAACTTGTTGTCTG
TTTTGTGATCTTGATTGTAG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAETILQASPLPQRLVVQLRQHFPLVDQRELAPLALAARASEFTVLLVDGETAVSAAQIAALPQLKLIAVFGVGYERVDV
LAARAQGVRVTHTPGVLTDDVADLAIGLLLATARQIGGAQRFIERGDWLQGGYPWTRKVSGARLGILGLGRIGRAIAQRA
TAFNMAVSYHSRQQYDDFSGRFFATPQALAEHCDFLLVCTNGGVATRALVDAKVLAALGANGILINIARGSVVDETALVK
AIDQGVIAGAGLDVFECEPQVPAGLMGRDNVVLTPHMASATHSTRRMMADLVFDNIAAYFAGRALPTPVAESPNP

Sequences:

>Translated_315_residues
MAETILQASPLPQRLVVQLRQHFPLVDQRELAPLALAARASEFTVLLVDGETAVSAAQIAALPQLKLIAVFGVGYERVDV
LAARAQGVRVTHTPGVLTDDVADLAIGLLLATARQIGGAQRFIERGDWLQGGYPWTRKVSGARLGILGLGRIGRAIAQRA
TAFNMAVSYHSRQQYDDFSGRFFATPQALAEHCDFLLVCTNGGVATRALVDAKVLAALGANGILINIARGSVVDETALVK
AIDQGVIAGAGLDVFECEPQVPAGLMGRDNVVLTPHMASATHSTRRMMADLVFDNIAAYFAGRALPTPVAESPNP
>Mature_314_residues
AETILQASPLPQRLVVQLRQHFPLVDQRELAPLALAARASEFTVLLVDGETAVSAAQIAALPQLKLIAVFGVGYERVDVL
AARAQGVRVTHTPGVLTDDVADLAIGLLLATARQIGGAQRFIERGDWLQGGYPWTRKVSGARLGILGLGRIGRAIAQRAT
AFNMAVSYHSRQQYDDFSGRFFATPQALAEHCDFLLVCTNGGVATRALVDAKVLAALGANGILINIARGSVVDETALVKA
IDQGVIAGAGLDVFECEPQVPAGLMGRDNVVLTPHMASATHSTRRMMADLVFDNIAAYFAGRALPTPVAESPNP

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=36.1867704280156, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=31.3380281690141, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=29.6442687747036, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=29.6442687747036, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=29.6442687747036, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557497, Length=228, Percent_Identity=30.2631578947368, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI61743967, Length=228, Percent_Identity=30.2631578947368, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87082289, Length=312, Percent_Identity=35.5769230769231, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789279, Length=266, Percent_Identity=30.0751879699248, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=31.9444444444444, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787645, Length=271, Percent_Identity=25.0922509225092, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=30.5660377358491, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=240, Percent_Identity=28.75, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=232, Percent_Identity=33.1896551724138, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=238, Percent_Identity=29.8319327731092, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=238, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=280, Percent_Identity=25.3571428571429, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=37.7952755905512, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=32.9457364341085, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551003, Length=258, Percent_Identity=32.9457364341085, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=32.9457364341085, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=32.9457364341085, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=32.9457364341085, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585516, Length=257, Percent_Identity=33.0739299610895, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=30.1754385964912, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=29.646017699115, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33381; Mature: 33250

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETILQASPLPQRLVVQLRQHFPLVDQRELAPLALAARASEFTVLLVDGETAVSAAQIA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHH
ALPQLKLIAVFGVGYERVDVLAARAQGVRVTHTPGVLTDDVADLAIGLLLATARQIGGAQ
HCCCEEEEEEECCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHH
RFIERGDWLQGGYPWTRKVSGARLGILGLGRIGRAIAQRATAFNMAVSYHSRQQYDDFSG
HHHHCCCCCCCCCCHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCC
RFFATPQALAEHCDFLLVCTNGGVATRALVDAKVLAALGANGILINIARGSVVDETALVK
EEEECHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
AIDQGVIAGAGLDVFECEPQVPAGLMGRDNVVLTPHMASATHSTRRMMADLVFDNIAAYF
HHHCCCEECCCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AGRALPTPVAESPNP
CCCCCCCCCCCCCCC
>Mature Secondary Structure 
AETILQASPLPQRLVVQLRQHFPLVDQRELAPLALAARASEFTVLLVDGETAVSAAQIA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHH
ALPQLKLIAVFGVGYERVDVLAARAQGVRVTHTPGVLTDDVADLAIGLLLATARQIGGAQ
HCCCEEEEEEECCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCHHH
RFIERGDWLQGGYPWTRKVSGARLGILGLGRIGRAIAQRATAFNMAVSYHSRQQYDDFSG
HHHHCCCCCCCCCCHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCC
RFFATPQALAEHCDFLLVCTNGGVATRALVDAKVLAALGANGILINIARGSVVDETALVK
EEEECHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
AIDQGVIAGAGLDVFECEPQVPAGLMGRDNVVLTPHMASATHSTRRMMADLVFDNIAAYF
HHHCCCEECCCCCEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AGRALPTPVAESPNP
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA