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The map label for this gene is glmS [H]

Identifier: 157368260

GI number: 157368260

Start: 9365

End: 11194

Strand: Direct

Name: glmS [H]

Synonym: Spro_0011

Alternate gene names: 157368260

Gene position: 9365-11194 (Clockwise)

Preceding gene: 157368259

Following gene: 157368261

Centisome position: 0.17

GC content: 57.6

Gene sequence:

>1830_bases
ATGTGTGGAATTGTAGGCGCAGTAGCGCAACGTGATATTGCAGAGATTCTGTTGGAAGGGTTACGCCGTCTTGAGTACCG
TGGCTACGACTCCGCCGGTTTGGCGGTGGTGGATGCCGAAGGCAACGTCAACCGTTTACGCCGCGTGGGCAAGGTTAACA
AACTGACCGAAGCCGCTGAACAACATGAATTGCATGGGGGCACCGGTATTGCTCACACCCGCTGGGCAACGCACGGTGAA
CCTACCGAAGCTAACGCGCACCCGCATGTTTCTGATTACATTACTGTGGTGCATAACGGCATCATCGAAAACCACGAACC
GCTGCGTGAACTGCTGATCGAACGCGGTTATCACTTCAGCTCTGAAACCGATACCGAGGTGATTGCTCACCTGGTACATT
GGGAACAGCGCCAGGGGGGCACCTTGCTGGAAGTGGTTCAGCGCGTGATCCCTCAGTTGCGTGGCGCATACGGCACCGTG
GTGATGGACAGCCGCGACCCTAGCGTGCTGGTGGCTGCGCGCTCCGGCAGCCCGTTGGTTATCGGCCGTGGCGTGGGTGA
AAACTTCCTGGCTTCCGATCAACTGGCATTGTTGCCGGTAACCCGTCGCTTTATCTTCCTGGAAGAAGGTGACGTGGTGG
AGATGACTCGCCGCACCGTCAACATTTTCGATAAGCAGGGCAACGCCGTTGAGCGTCCTGAAATCGAATCTCAGGTGCAG
TACGACGCCGGTGACAAAGGTGCTTACCGTCACTACATGCAAAAAGAGATCTACGAACAGCCACTGGCGCTGAAGAACAC
CCTGGAAGGGCGTTTCAGCCAGGGCAAAATCAACCTGAGCGAGCTGGGCCCGCGTGCCGATGAACTGTTGGCGAAGGTGC
AGCACGTGCAAATCATTGCCTGTGGGACGTCTTACCACTCCGGCATGGTTGCCCGCTATTGGTTCGAATCGCTGGCCGGC
GTGCCTTGCGACGTGGAAATCGCGTCAGAATTCCGCTATCGCAAATCTGCCGTGCGTCCGGGCAGTCTGATCATTACCTT
GTCGCAGTCCGGTGAAACTGCCGATACGCTGGCGGCACTGCGTCTGTCGAAGGAGCTGGGTTACCTCGGTTCACTGGCGG
TGTGCAACGTGGCCGGTTCTTCACTGGTGCGTGAATCCGATCTGGCGCTGATGACCAAGGCCGGTACCGAAATCGGTGTC
GCCTCCACCAAGGCCTTTACCACCCAGCTTGCGGTGCTGTTGATGCTGGTGGCGCGTTTGGGCCGGCTGAAAGGCATGGC
GGAAAGCGTTGAGCATGAAATCGTGCACGGCCTGCAGGCATTGCCGGCGCGTATTGAGCAGATGCTGTCGCTGGACAAAA
ACATTGAAGCGTTGGCGGAAGGCTTCTCCGACAAGCATCACGCGCTGTTCCTCGGCCGTGGCGATCAGTACCCGATCGCG
ATGGAAGGTGCGCTGAAGCTCAAAGAGATCTCCTATATTCACGCGGAAGCCTATGCGGCCGGTGAGTTGAAACACGGCCC
GTTGGCGTTGATCGATGCCGATATGCCGGTGATCGTGGTGGCGCCGAACAACGAACTGTTGGAAAAGCTGAAGTCCAACA
TTGAAGAAGTGCGCGCGCGCGGCGGCCAGCTGTATGTGTTCGCCGATCAGGATGCCGGTTTCGTCAGCAGCGAGGGTATG
ACTATCATCCCGTTGCCGCACGTCGAAGAAATCGTGGCACCGATCTTCTACACCGTACCGTTGCAGTTGCTGTCTTACCA
CGTGGCGCTGATCAAAGGTACCGACGTTGACCAGCCGCGTAACCTGGCGAAGTCTGTCACGGTAGAGTAA

Upstream 100 bases:

>100_bases
CCCCATTCTCTACAGGCTCGGGGACGCACGGTAAAAACCGGCAAAATCAGGTCAAGGCATCGAAAGCGCCCCGAAAGGCG
TTTAATTAGGAATACAACTG

Downstream 100 bases:

>100_bases
CTCGCTGCTGTTAACCTCTAAAAGCCGGCCACTGTGCCGGCTTTTTCATGATTGGATCAAATATGACAATGGTGCGACAG
CAGGGATAAAAGTTGTCATA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLTEAAEQHELHGGTGIAHTRWATHGE
PTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFSSETDTEVIAHLVHWEQRQGGTLLEVVQRVIPQLRGAYGTV
VMDSRDPSVLVAARSGSPLVIGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSQGKINLSELGPRADELLAKVQHVQIIACGTSYHSGMVARYWFESLAG
VPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAALRLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLAVLLMLVARLGRLKGMAESVEHEIVHGLQALPARIEQMLSLDKNIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSEGM
TIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLTEAAEQHELHGGTGIAHTRWATHGE
PTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFSSETDTEVIAHLVHWEQRQGGTLLEVVQRVIPQLRGAYGTV
VMDSRDPSVLVAARSGSPLVIGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSQGKINLSELGPRADELLAKVQHVQIIACGTSYHSGMVARYWFESLAG
VPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAALRLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLAVLLMLVARLGRLKGMAESVEHEIVHGLQALPARIEQMLSLDKNIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSEGM
TIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLTEAAEQHELHGGTGIAHTRWATHGE
PTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFSSETDTEVIAHLVHWEQRQGGTLLEVVQRVIPQLRGAYGTV
VMDSRDPSVLVAARSGSPLVIGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSQGKINLSELGPRADELLAKVQHVQIIACGTSYHSGMVARYWFESLAG
VPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAALRLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGV
ASTKAFTTQLAVLLMLVARLGRLKGMAESVEHEIVHGLQALPARIEQMLSLDKNIEALAEGFSDKHHALFLGRGDQYPIA
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRARGGQLYVFADQDAGFVSSEGM
TIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=38.7190684133916, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=38.5735080058224, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI29570798, Length=269, Percent_Identity=26.7657992565056, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790167, Length=609, Percent_Identity=84.5648604269294, Blast_Score=1068, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=262, Percent_Identity=30.5343511450382, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539970, Length=439, Percent_Identity=38.9521640091116, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17532897, Length=519, Percent_Identity=35.0674373795761, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17532899, Length=429, Percent_Identity=38.6946386946387, Blast_Score=280, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322745, Length=447, Percent_Identity=38.255033557047, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=31.7351598173516, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=39.7058823529412, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=36.734693877551, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28573187, Length=270, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24659598, Length=268, Percent_Identity=26.1194029850746, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24659604, Length=248, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66657; Mature: 66657

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00443 GATASE_TYPE_II ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLTEAAE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
QHELHGGTGIAHTRWATHGEPTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
SETDTEVIAHLVHWEQRQGGTLLEVVQRVIPQLRGAYGTVVMDSRDPSVLVAARSGSPLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEE
IGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
EECCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHC
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSQGKINLSELGPRADELLAKVQHVQIIA
CCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHCCCCHHHHHHHHHHEEEEE
CGTSYHSGMVARYWFESLAGVPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHH
RLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGVASTKAFTTQLAVLLMLVARL
HHHHHHCCCCCHHHHHHCCHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GRLKGMAESVEHEIVHGLQALPARIEQMLSLDKNIEALAEGFSDKHHALFLGRGDQYPIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGQLYVFADQDAGFVSSEGMTIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAVAQRDIAEILLEGLRRLEYRGYDSAGLAVVDAEGNVNRLRRVGKVNKLTEAAE
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
QHELHGGTGIAHTRWATHGEPTEANAHPHVSDYITVVHNGIIENHEPLRELLIERGYHFS
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
SETDTEVIAHLVHWEQRQGGTLLEVVQRVIPQLRGAYGTVVMDSRDPSVLVAARSGSPLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEE
IGRGVGENFLASDQLALLPVTRRFIFLEEGDVVEMTRRTVNIFDKQGNAVERPEIESQVQ
EECCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHC
YDAGDKGAYRHYMQKEIYEQPLALKNTLEGRFSQGKINLSELGPRADELLAKVQHVQIIA
CCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHCCCCHHHHHHHHHHEEEEE
CGTSYHSGMVARYWFESLAGVPCDVEIASEFRYRKSAVRPGSLIITLSQSGETADTLAAL
ECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHH
RLSKELGYLGSLAVCNVAGSSLVRESDLALMTKAGTEIGVASTKAFTTQLAVLLMLVARL
HHHHHHCCCCCHHHHHHCCHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
GRLKGMAESVEHEIVHGLQALPARIEQMLSLDKNIEALAEGFSDKHHALFLGRGDQYPIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCEE
MEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
ECCCEEHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGQLYVFADQDAGFVSSEGMTIIPLPHVEEIVAPIFYTVPLQLLSYHVALIKGTDVDQPR
CCEEEEEECCCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]