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The map label for this gene is glmU

Identifier: 157368259

GI number: 157368259

Start: 7783

End: 9153

Strand: Direct

Name: glmU

Synonym: Spro_0010

Alternate gene names: 157368259

Gene position: 7783-9153 (Clockwise)

Preceding gene: 157368258

Following gene: 157368260

Centisome position: 0.14

GC content: 57.4

Gene sequence:

>1371_bases
ATGTCGAACAGCGCAATGAGTGTGGTGATCCTCGCCGCGGGCAAGGGAACACGCATGTATTCCGATCTTCCCAAGGTGTT
ACATCCGTTGGCCGGCAAGCCGATGGTGCAGCACGTCATTGATGCCGCGATGAAACTGGGCGCGAAAAACGTCCATCTGG
TGTACGGCCATGGCGGCGACTTGCTGAAAAACACCCTGACCGACGGCGCACTGAACTGGGTGCTGCAGGCCGAGCAATTG
GGTACCGGCCATGCCATGCAGCAAGCGGCCCCGCATTTTGCCGATGATGAAGACGTGCTGATGCTGTACGGCGACGTCCC
GCTGATTTCTGTCGATACTTTGCAGCGTCTGATGGCCGCGAAACCCCAGGGCGGCATTGGCCTGCTGACGGTGAAGCTGG
CGGATCCGAGCGGTTACGGCCGTATTGTGCGTGAAAACGACCAGGTAGTGGGGATTGTTGAGCACAAGGATGCCAACGAA
GCCCAACGCCAAATCAATGAAATCAACACCGGCATCCTGGTGGCCAACGGCCGCGATCTCAAGCGCTGGTTGGGGATGCT
GAATAACGACAACGCACAGGGTGAATTCTACATCACCGATATCATTGCGCTGGCCCATGCCGACGGCAAGAAAATTGAAG
CCGTGCATCCGTCACGCCTGAGTGAAGTGGAAGGCGTGAATAACCGTCTGCAACTGTCGCGACTTGAGCGTATCTACCAG
GCAGAACAGTCTGAAAAATTACTGTTGGCCGGGGTAATGCTGCTGGATCCGGCGCGTTTTGACCTGCGTGGGGAACTTGT
GCACGGCCGCGACATCTCTATTGATGCCAACGTGATTATTGAAGGCACGGTCAAGCTCGGGGATAGAGTGAAAATCGGTG
CCGGCTGCGTGTTGAAAAACTGCGTGATCGGCGATGACTGCGAAATCAGCCCGTACAGCGTGCTGGAAGATGCCGTGCTG
GCAGCGGAATGCACCGTGGGTCCCTTTGCCCGCCTGCGTCCTGGCGCTGAGCTGGCGGTGGGTGCCCATGTCGGCAACTT
CGTCGAAATGAAAAAGGCGCGTTTGGGCAAAGGTTCTAAAGCGGGCCATCTGAGCTACCTGGGCGACGCCGAGATTGGCG
ACGATGTGAATATTGGTGCCGGTACCATCACCTGTAACTATGATGGCGCCAATAAGCATAAAACCATTATCGGCGACGGC
GTGTTTGTCGGTTCCGACACCCAGCTGGTGGCGCCAGTGTCTGTCGGCAAAGGTTCGACCATCGCCGCAGGCACTACGGT
GACCCGTGATATCGGCGAAGACGAACTGGTGCTGAGCCGCGTCAAGCAGGTGCATATCCAGGGCTGGCAGCGTCCGGTCA
AGAAGAAGTAA

Upstream 100 bases:

>100_bases
GCCCCAAGGCCTGAGCTGGGTTCGTGCAGAGAAATATGTAGTAATATCGTCACTAAAGAGTTCTACTTTCGTCTATTAAA
ATGGAGTTATCAGGTTGCTT

Downstream 100 bases:

>100_bases
CAACTTAGACTCCCTCTCCTTTTGGGAGAGGGCCGGGGTGAGGGGGCTGACGGCTCCTCACCCTGTTTTGCCCTGTGCTT
TGGTGCAGAGTGCAGGGCAA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSNSAMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAKNVHLVYGHGGDLLKNTLTDGALNWVLQAEQL
GTGHAMQQAAPHFADDEDVLMLYGDVPLISVDTLQRLMAAKPQGGIGLLTVKLADPSGYGRIVRENDQVVGIVEHKDANE
AQRQINEINTGILVANGRDLKRWLGMLNNDNAQGEFYITDIIALAHADGKKIEAVHPSRLSEVEGVNNRLQLSRLERIYQ
AEQSEKLLLAGVMLLDPARFDLRGELVHGRDISIDANVIIEGTVKLGDRVKIGAGCVLKNCVIGDDCEISPYSVLEDAVL
AAECTVGPFARLRPGAELAVGAHVGNFVEMKKARLGKGSKAGHLSYLGDAEIGDDVNIGAGTITCNYDGANKHKTIIGDG
VFVGSDTQLVAPVSVGKGSTIAAGTTVTRDIGEDELVLSRVKQVHIQGWQRPVKKK

Sequences:

>Translated_456_residues
MSNSAMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAKNVHLVYGHGGDLLKNTLTDGALNWVLQAEQL
GTGHAMQQAAPHFADDEDVLMLYGDVPLISVDTLQRLMAAKPQGGIGLLTVKLADPSGYGRIVRENDQVVGIVEHKDANE
AQRQINEINTGILVANGRDLKRWLGMLNNDNAQGEFYITDIIALAHADGKKIEAVHPSRLSEVEGVNNRLQLSRLERIYQ
AEQSEKLLLAGVMLLDPARFDLRGELVHGRDISIDANVIIEGTVKLGDRVKIGAGCVLKNCVIGDDCEISPYSVLEDAVL
AAECTVGPFARLRPGAELAVGAHVGNFVEMKKARLGKGSKAGHLSYLGDAEIGDDVNIGAGTITCNYDGANKHKTIIGDG
VFVGSDTQLVAPVSVGKGSTIAAGTTVTRDIGEDELVLSRVKQVHIQGWQRPVKKK
>Mature_455_residues
SNSAMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAKNVHLVYGHGGDLLKNTLTDGALNWVLQAEQLG
TGHAMQQAAPHFADDEDVLMLYGDVPLISVDTLQRLMAAKPQGGIGLLTVKLADPSGYGRIVRENDQVVGIVEHKDANEA
QRQINEINTGILVANGRDLKRWLGMLNNDNAQGEFYITDIIALAHADGKKIEAVHPSRLSEVEGVNNRLQLSRLERIYQA
EQSEKLLLAGVMLLDPARFDLRGELVHGRDISIDANVIIEGTVKLGDRVKIGAGCVLKNCVIGDDCEISPYSVLEDAVLA
AECTVGPFARLRPGAELAVGAHVGNFVEMKKARLGKGSKAGHLSYLGDAEIGDDVNIGAGTITCNYDGANKHKTIIGDGV
FVGSDTQLVAPVSVGKGSTIAAGTTVTRDIGEDELVLSRVKQVHIQGWQRPVKKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=456, Percent_Identity=81.7982456140351, Blast_Score=767, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SERP5 (A8G7N0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476248.1
- ProteinModelPortal:   A8G7N0
- SMR:   A8G7N0
- STRING:   A8G7N0
- GeneID:   5603655
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0010
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK09451
- BioCyc:   SPRO399741:SPRO_0010-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48736; Mature: 48604

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 363-363 BINDING 76-76 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 387-387 BINDING 405-405 BINDING 423-423 BINDING 440-440

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSAMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAKNVHLVYGHGGD
CCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCH
LLKNTLTDGALNWVLQAEQLGTGHAMQQAAPHFADDEDVLMLYGDVPLISVDTLQRLMAA
HHHHHHCCCHHHHEEEHHHCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHC
KPQGGIGLLTVKLADPSGYGRIVRENDQVVGIVEHKDANEAQRQINEINTGILVANGRDL
CCCCCEEEEEEEEECCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCHH
KRWLGMLNNDNAQGEFYITDIIALAHADGKKIEAVHPSRLSEVEGVNNRLQLSRLERIYQ
HHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHH
AEQSEKLLLAGVMLLDPARFDLRGELVHGRDISIDANVIIEGTVKLGDRVKIGAGCVLKN
HCCCCEEEEEEEEEECCCCCCEEEEEECCCEEEECCEEEEEEEEECCCEEEECCCEEEEC
CVIGDDCEISPYSVLEDAVLAAECTVGPFARLRPGAELAVGAHVGNFVEMKKARLGKGSK
CEECCCCCCCCHHHHHHHHHEEECCCCCHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCC
AGHLSYLGDAEIGDDVNIGAGTITCNYDGANKHKTIIGDGVFVGSDTQLVAPVSVGKGST
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCEEECCCCEEEEEEECCCCCE
IAAGTTVTRDIGEDELVLSRVKQVHIQGWQRPVKKK
EECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNSAMSVVILAAGKGTRMYSDLPKVLHPLAGKPMVQHVIDAAMKLGAKNVHLVYGHGGD
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCH
LLKNTLTDGALNWVLQAEQLGTGHAMQQAAPHFADDEDVLMLYGDVPLISVDTLQRLMAA
HHHHHHCCCHHHHEEEHHHCCCCHHHHHCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHC
KPQGGIGLLTVKLADPSGYGRIVRENDQVVGIVEHKDANEAQRQINEINTGILVANGRDL
CCCCCEEEEEEEEECCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCCHH
KRWLGMLNNDNAQGEFYITDIIALAHADGKKIEAVHPSRLSEVEGVNNRLQLSRLERIYQ
HHHHHHHCCCCCCCCEEEEEEEEEECCCCCEEEEECCHHHHHHHCCCCHHHHHHHHHHHH
AEQSEKLLLAGVMLLDPARFDLRGELVHGRDISIDANVIIEGTVKLGDRVKIGAGCVLKN
HCCCCEEEEEEEEEECCCCCCEEEEEECCCEEEECCEEEEEEEEECCCEEEECCCEEEEC
CVIGDDCEISPYSVLEDAVLAAECTVGPFARLRPGAELAVGAHVGNFVEMKKARLGKGSK
CEECCCCCCCCHHHHHHHHHEEECCCCCHHHCCCCCCEEEECCCCHHHHHHHHHCCCCCC
AGHLSYLGDAEIGDDVNIGAGTITCNYDGANKHKTIIGDGVFVGSDTQLVAPVSVGKGST
CCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEEECCEEECCCCEEEEEEECCCCCE
IAAGTTVTRDIGEDELVLSRVKQVHIQGWQRPVKKK
EECCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA