Click here to switch to the map view.

The map label for this gene is fbp [H]

Identifier: 157163706

GI number: 157163706

Start: 4489806

End: 4490804

Strand: Reverse

Name: fbp [H]

Synonym: EcHS_A4485

Alternate gene names: 157163706

Gene position: 4490804-4489806 (Counterclockwise)

Preceding gene: 157163708

Following gene: 157163701

Centisome position: 96.71

GC content: 50.95

Gene sequence:

>999_bases
ATGAAAACGTTAGGTGAATTTATTGTCGAAAAGCAGCACGAGTTTTCTCATGCTACCGGTGAGCTCACTGCTTTGCTGTC
GGCAATAAAACTGGGCGCCAAGATTATCCATCGCGATATCAACAAAGCAGGACTGGTTGATATCCTGGGTGCCAGCGGTG
CTGAGAACGTGCAGGGCGAGGTTCAGCAAAAACTCGACTTGTTCGCTAATGAAAAACTGAAAGCCGCACTGAAAGCACGC
GATATCGTTGCAGGCATTGCCTCTGAAGAAGAAGATGAGATTGTTGTCTTTGAAGGCTGTGAACATGCAAAATACGTGGT
GCTGATGGACCCACTGGATGGCTCGTCCAACATCGATGTTAACGTCTCTGTCGGTACCATTTTCTCCATCTACCGCCGAG
TTACGCCCGTCGGCACGCCGGTAACGGAAGAAGATTTCCTCCAGCCTGGTAACAAACAGGTTGCGGCAGGTTACGTGGTA
TACGGCTCCTCTACCATGCTGGTTTACACCACCGGATGCGGTGTTCACGCCTTTACTTACGATCCTTCGCTGGGCGTTTT
CTGCCTGTGCCAGGAACGGATGCGCTTCCCGGAGAAAGGCAAAACCTACTCCATCAACGAAGGAAACTACATTAAGTTTC
CGAACGGGGTGAAGAAGTACATTAAATTCTGCCAGGAAGAAGATAAATCCACCAACCGCCCGTATACCTCACGTTATATC
GGTTCACTGGTTGCGGATTTCCACCGTAACCTGCTGAAAGGCGGTATTTATCTCTACCCAAGCACCGCCAGCCACCCGGA
CGGCAAACTGCGTTTGCTTTATGAGTGCAACCCGATGGCATTCCTGGCGGAACAAGCGGGCGGTAAAGCGAGCGATGGCA
AAGAGCGTATTCTGGATATCATCCCGGAAACTCTGCACCAGCGCCGTTCGTTCTTTGTCGGCAACGACCATATGGTTGAA
GATGTCGAACGCTTTATCCGTGAGTTCCCGGACGCGTAA

Upstream 100 bases:

>100_bases
TCCGTAATTTGCTGGCGCGATTCACCTGAGCGCAACATTGAGATTATTTGTTAAGATTGTTGCGGTCGCTTTACTCCATA
AACATTGCAGGGAAAGTTTT

Downstream 100 bases:

>100_bases
TCTCCTGCGCCTCTCCACACGGAGAGGCGTTTTTATTGCTGCGCAATGTTGACTCTTGTCACTGGCGAACTCTGACGATT
CTCCCACAGCACCGTTAATC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFIREFPDA

Sequences:

>Translated_332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFIREFPDA
>Mature_332_residues
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVE
DVERFIREFPDA

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=329, Percent_Identity=44.3768996960486, Blast_Score=266, Evalue=1e-71,
Organism=Homo sapiens, GI16579888, Length=329, Percent_Identity=44.3768996960486, Blast_Score=266, Evalue=1e-71,
Organism=Homo sapiens, GI22907028, Length=329, Percent_Identity=43.4650455927052, Blast_Score=248, Evalue=4e-66,
Organism=Escherichia coli, GI1790679, Length=332, Percent_Identity=100, Blast_Score=686, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508131, Length=327, Percent_Identity=46.7889908256881, Blast_Score=300, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6323409, Length=315, Percent_Identity=44.4444444444444, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI45550998, Length=325, Percent_Identity=47.6923076923077, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI19921562, Length=325, Percent_Identity=47.6923076923077, Blast_Score=298, Evalue=4e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 36834; Mature: 36834

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
CCCCCCEEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPETLHQRRSFFVGNDHMVEDVERFIREFPDA
HHHHHHHHHHEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLVDILGASGAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYI
CCCCCCEEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPETLHQRRSFFVGNDHMVEDVERFIREFPDA
HHHHHHHHHHEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA