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The map label for this gene is ygcS [H]

Identifier: 157162221

GI number: 157162221

Start: 2913765

End: 2915102

Strand: Reverse

Name: ygcS [H]

Synonym: EcHS_A2911

Alternate gene names: 157162221

Gene position: 2915102-2913765 (Counterclockwise)

Preceding gene: 157162222

Following gene: 157162220

Centisome position: 62.78

GC content: 53.29

Gene sequence:

>1338_bases
ATGAACACTTCACCGGTGCGAATGGATGATTTACCGCTTAACCGTTTTCACTGTCGAATTGCTGCGCTCACTTTCGGCGC
ACACCTGACCGACGGTTATGTTCTCGGCGTCATTGGTTACGCCATTATTCAGCTTACGCCCGCCATGCAACTGACGCCGT
TTATGGCGGGAATGATCGGCGGCTCGGCGCTCCTTGGTTTGTTTCTTGGCAGCCTGGTTCTTGGGTGGATCTCCGACCAT
ATTGGTCGGCAAAAAATCTTCACCTTCAGCTTTTTGCTGATTACGCTCGCTTCGTTCTTGCAATTTTTTGCCACCAAGCC
AGAGCATCTTATTGGGCTGCGCATTTTGATCGGCATTGGGCTGGGAGGCGATTACTCAGTTGGTCACACCTTGCTGGCTG
AATTTTCCCCGCGCCGCCATCGCGGTATTTTGCTGGGCGCATTCAGCGTGGTGTGGACCGTAGGTTATGTGCTGGCAAGT
ATTGCCGGACATCACTTTATTTCCGAAAACCCGGAGGCCTGGCGCTGGCTGTTGGCATCGGCAGCTCTGCCCGCGTTGTT
GATTACGTTATTACGCTGGGGAACGCCAGAATCGCCACGCTGGCTACTGCGCCAGGGGCGTTTTGCAGAAGCTCACGCTA
TCGTGCATCGCTATTTTGGTCCCCATGTTTTACTGGGCGATGAAGTGGTAACGGCGACCCATAAACACATCAAAACCTTG
TTCTCTTCGCGTTACTGGCGGCGCACGGCGTTTAACAGCGTCTTCTTTGTCTGCCTCGTAATCCCATGGTTTGTGATTTA
TACCTGGCTGCCAACTATCGCCCAGACTATTGGTCTGGAAGATGCGCTGACTGCCAGCCTGATGCTTAATGCGTTGTTAA
TTGTAGGCGCGCTGCTGGGATTAGTTCTGACGCACCTGCTGGCACATCGCAAATTTTTGCTGGGAAGTTTTTTGCTGCTG
GCGGCAACGCTGGTAGTGATGGCCTGTTTGCCTGCCGGCAGTTCATTAACGCTGCTGCTTTTTGTTCTCTTCAGCACCAC
CATTTCGGCAGTCAGTAATCTGGTGGGCATTTTGCCTGCGGAAAGTTTTCCTACTGACATTCGCTCGCTGGGCGTCGGTT
TTGCCACCGCTATGAGTCGGTTGGGGGCGGCAGTAAGTACTGGCCTGCTACCGTGGGTGCTGGCGCAGTGGGGAATGCAA
GTCACCTTATTGCTCCTGGCGACAGTGTTGTTAGTTGGTTTTGTCGTGACCTGGCTATGGGCACCAGAAACCAAAGCACT
CCCGCTGGTGGCGGCGGGAAATGTAGGAGGTGCTAATGAACATTCTGTTAGCGTTTAA

Upstream 100 bases:

>100_bases
AAAATAATGTATCAGGCAGCGTTCCGCGATGACGGGGCGTTGCCTTTTCGGCTTCTCAGGCGAGAAGCCGTTCTTATTAC
CGGACAATGAAGGGGTAAAG

Downstream 100 bases:

>100_bases
AGCCGAACCGGATGCCGGAATGCTGGCGGAAAAAGAGTGGCAGGCGGCGACTCAGGGTAATAGCGGACCGGATGTTTCGT
TACTGCGAAGTTTACTCGGT

Product: major facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATKPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPAGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
VTLLLLATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV

Sequences:

>Translated_445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATKPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPAGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
VTLLLLATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV
>Mature_445_residues
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIGGSALLGLFLGSLVLGWISDH
IGRQKIFTFSFLLITLASFLQFFATKPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLAS
IAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTL
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLL
AATLVVMACLPAGSSLTLLLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQ
VTLLLLATVLLVGFVVTWLWAPETKALPLVAAGNVGGANEHSVSV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI4507005, Length=383, Percent_Identity=26.3707571801567, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI302148518, Length=365, Percent_Identity=24.9315068493151, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4506999, Length=425, Percent_Identity=25.4117647058824, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI24497490, Length=334, Percent_Identity=26.0479041916168, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI166197673, Length=365, Percent_Identity=28.2191780821918, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI24308167, Length=446, Percent_Identity=23.7668161434978, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI23510410, Length=374, Percent_Identity=24.0641711229947, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI7662270, Length=211, Percent_Identity=27.4881516587678, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI21553331, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI296080721, Length=154, Percent_Identity=35.0649350649351, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI296080734, Length=217, Percent_Identity=31.3364055299539, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI296080719, Length=346, Percent_Identity=25.7225433526012, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI24497499, Length=346, Percent_Identity=25.7225433526012, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20070188, Length=380, Percent_Identity=25.7894736842105, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI24497476, Length=380, Percent_Identity=25.7894736842105, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI213021148, Length=415, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI24497497, Length=348, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI90669191, Length=348, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI8923870, Length=382, Percent_Identity=24.3455497382199, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI11415038, Length=375, Percent_Identity=24.8, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI203098995, Length=197, Percent_Identity=27.4111675126904, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI166064021, Length=376, Percent_Identity=25, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082159, Length=445, Percent_Identity=99.5505617977528, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1786229, Length=431, Percent_Identity=34.338747099768, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788074, Length=418, Percent_Identity=26.0765550239234, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788068, Length=451, Percent_Identity=24.6119733924612, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789207, Length=208, Percent_Identity=32.2115384615385, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790463, Length=427, Percent_Identity=23.4192037470726, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789312, Length=436, Percent_Identity=24.0825688073394, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082404, Length=405, Percent_Identity=22.7160493827161, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082231, Length=416, Percent_Identity=24.0384615384615, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556354, Length=408, Percent_Identity=27.9411764705882, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565976, Length=154, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565978, Length=328, Percent_Identity=26.219512195122, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560496, Length=395, Percent_Identity=23.5443037974684, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988651, Length=156, Percent_Identity=34.6153846153846, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17564080, Length=407, Percent_Identity=25.0614250614251, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193209824, Length=388, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554160, Length=403, Percent_Identity=25.0620347394541, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=179, Percent_Identity=30.7262569832402, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324469, Length=458, Percent_Identity=21.17903930131, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649618, Length=339, Percent_Identity=25.9587020648968, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922616, Length=394, Percent_Identity=25.3807106598985, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24649622, Length=387, Percent_Identity=24.2894056847545, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668456, Length=408, Percent_Identity=25.4901960784314, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24668440, Length=406, Percent_Identity=24.1379310344828, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640198, Length=440, Percent_Identity=23.8636363636364, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640196, Length=440, Percent_Identity=23.8636363636364, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640200, Length=440, Percent_Identity=23.8636363636364, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24649616, Length=356, Percent_Identity=26.123595505618, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078338, Length=399, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077756, Length=455, Percent_Identity=23.956043956044, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922874, Length=406, Percent_Identity=25.1231527093596, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24647365, Length=404, Percent_Identity=25.990099009901, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48246; Mature: 48246

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIG
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATKPEHLIGLRILIGIG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEC
LGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLAS
CCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHH
AALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTL
HHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LVLTHLLAHRKFLLGSFLLLAATLVVMACLPAGSSLTLLLFVLFSTTISAVSNLVGILPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APETKALPLVAAGNVGGANEHSVSV
CCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNTSPVRMDDLPLNRFHCRIAALTFGAHLTDGYVLGVIGYAIIQLTPAMQLTPFMAGMIG
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATKPEHLIGLRILIGIG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEC
LGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLAS
CCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHH
AALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHRYFGPHVLLGDEVVTATHKHIKTL
HHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
FSSRYWRRTAFNSVFFVCLVIPWFVIYTWLPTIAQTIGLEDALTASLMLNALLIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LVLTHLLAHRKFLLGSFLLLAATLVVMACLPAGSSLTLLLFVLFSTTISAVSNLVGILPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
ESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APETKALPLVAAGNVGGANEHSVSV
CCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]