Click here to switch to the map view.

The map label for this gene is ykgC [H]

Identifier: 157159809

GI number: 157159809

Start: 369273

End: 370598

Strand: Reverse

Name: ykgC [H]

Synonym: EcHS_A0356

Alternate gene names: 157159809

Gene position: 370598-369273 (Counterclockwise)

Preceding gene: 157159815

Following gene: 157159807

Centisome position: 7.98

GC content: 45.55

Gene sequence:

>1326_bases
ATGAATAAATATCAGGCAGTTATTATTGGTTTTGGCAAGGCTGGAAAAACATTAGCCGTCACGCTGGCAAAAGCAGGTTG
GCGAGTGGCTCTCATCGAACAATCAAATGCAATGTATGGCGGGACCTGTATTAATATCGGCTGCATCCCAACCAAAACAT
TGGTTCATGACGCACAGCAGCACACAGATTTTGTCCGTGCCATACAGCGTAAAAATGAAGTGGTTAATTTTTTACGTAAT
AAGAATTTTCATAATCTTGCGGATATGCCCAATATCGACGTGATCGACGGCCAGGCGGAGTTTATCAATAATCATAGCCT
GCGTGTTCATCGGCCTGAGGGAAATCTGGAAATTCATGGCGAGAAAATTTTTATTAATACCGGTGCACAAACCGTGGTTC
CGCCAATTCCTGGAATTACCACCACGCCTGGTGTATATGACAGCACCGGATTACTTAATCTAAAAGAATTGCCTGGGCAT
TTAGGTATTTTGGGCGGCGGATATATTGGCGTTGAGTTCGCCTCTATGTTCGCTAATTTTGGCAGCAAGGTAACCATTTT
AGAAGCAGCTTCGCTGTTTTTGCCTCGGGAAGATCGGGATATTGCTGATAATATCGCGACGATTTTACGCGATCAGGGCG
TCGATATTATCCTCAATGCCCATGTGGAGCGAATCAGTCACCATGAAAATCAAGTGCAAGTGCATAGCGAGCACGCCCAA
CTGGCGGTGGATGCACTGTTAATAGCTTCCGGTCGTCAACCGGCTACCGCTTCGTTACATCCAGAAAATGCCGGTATCGC
AGTAAACGAGCGCGGGGCAATTGTCGTTGACAAGCAATTACATACCACCGCAGACAATATTTGGGCGATGGGAGATGTTA
CCGGCGGGCTGCAATTTACTTATATTTCACTGGATGATTACCGCATTGTGCGTGATGAGTTGCTGGGAGAAGGCAGACGT
AGTACTGATGATCGGAAAAATGTGCCTTATTCCGTATTCATGACACCGCCACTGTCCAGGGTTGGTATGACAGAAGAACA
GGCCAGAGAGAGTGGTGCTGATATTCAGGTGGTGACATTGCCTGTAGCTGCAATTCCGCGTGCCAGAGTGATGAATGATA
CTCGTGGGGTATTAAAAGCGATTGTTGATAATAAAACCCAACGTATATTAGGGGCATCACTGCTGTGTGTTGACTCCCAC
GAGATGATCAATATAGTGAAAATGGTGATGGATGCCGGGCTGCCTTATAGCATATTACGCGATCAGATATTTACTCATCC
GTCGATGAGCGAATCACTCAATGATCTATTTTCATTAGTCAAATAA

Upstream 100 bases:

>100_bases
GACGATAAGACAAAATATCAAGCGTTGTGAAGAAATGGTATTTGCTCTTTTGCGTCTATAGTCATGATGTCAAATGAACG
CGTTTCGACAGGAAATCATC

Downstream 100 bases:

>100_bases
ACTCAAAATCAGACGCCAGAACAAATATTCTGGCGTCTCAGAGAAAAGAATCTTATTAATTCCCTGTTACTCTATAACTT
CTTAATCACTTCATTGATGG

Product: pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQHTDFVRAIQRKNEVVNFLRN
KNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHGEKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGH
LGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQ
LAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKQLHTTADNIWAMGDVTGGLQFTYISLDDYRIVRDELLGEGRR
STDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDTRGVLKAIVDNKTQRILGASLLCVDSH
EMINIVKMVMDAGLPYSILRDQIFTHPSMSESLNDLFSLVK

Sequences:

>Translated_441_residues
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQHTDFVRAIQRKNEVVNFLRN
KNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHGEKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGH
LGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQ
LAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKQLHTTADNIWAMGDVTGGLQFTYISLDDYRIVRDELLGEGRR
STDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDTRGVLKAIVDNKTQRILGASLLCVDSH
EMINIVKMVMDAGLPYSILRDQIFTHPSMSESLNDLFSLVK
>Mature_441_residues
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQHTDFVRAIQRKNEVVNFLRN
KNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHGEKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGH
LGILGGGYIGVEFASMFANFGSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQ
LAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKQLHTTADNIWAMGDVTGGLQFTYISLDDYRIVRDELLGEGRR
STDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTLPVAAIPRARVMNDTRGVLKAIVDNKTQRILGASLLCVDSH
EMINIVKMVMDAGLPYSILRDQIFTHPSMSESLNDLFSLVK

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=29.2841648590022, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI50301238, Length=450, Percent_Identity=27.7777777777778, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI148277065, Length=435, Percent_Identity=23.448275862069, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI33519430, Length=435, Percent_Identity=23.9080459770115, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI33519428, Length=435, Percent_Identity=23.9080459770115, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI33519426, Length=435, Percent_Identity=23.9080459770115, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI148277071, Length=435, Percent_Identity=23.448275862069, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI291045266, Length=439, Percent_Identity=23.9179954441913, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI22035672, Length=432, Percent_Identity=24.7685185185185, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87081717, Length=441, Percent_Identity=99.3197278911565, Blast_Score=903, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=28.3516483516484, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=27.5862068965517, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=28.2407407407407, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789065, Length=215, Percent_Identity=29.3023255813954, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=28.322440087146, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=26.1603375527426, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=25.2293577981651, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=25.2293577981651, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982272, Length=439, Percent_Identity=20.2733485193622, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=31.2765957446809, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=444, Percent_Identity=23.1981981981982, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=496, Percent_Identity=25.2016129032258, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358499, Length=457, Percent_Identity=28.8840262582057, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=27.1008403361345, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=27.1008403361345, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=27.1008403361345, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737741, Length=479, Percent_Identity=25.2609603340292, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48227; Mature: 48227

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQ
CCCEEEEEEEECCCCCEEEEEEECCCEEEEEEECCCCEECCEEEEECCCCCHHHHHHHHH
HTDFVRAIQRKNEVVNFLRNKNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHCCCCEEEECCCCCEEEEC
EKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGHLGILGGGYIGVEFASMFANF
CEEEEECCCCEECCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEECCCCHHHHHHHHHHHC
GSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQ
CCEEEEEEHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCEEEEHHHHH
LAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKQLHTTADNIWAMGDVTGGLQFT
HHHHHHEEECCCCCCEEECCCCCCCEEECCCCCEEECCCHHCCCCCEEEEECCCCCEEEE
YISLDDYRIVRDELLGEGRRSTDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTL
EEECCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHCCCHHHHHHCCCCEEEEEE
PVAAIPRARVMNDTRGVLKAIVDNKTQRILGASLLCVDSHEMINIVKMVMDAGLPYSILR
CHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCHHHHH
DQIFTHPSMSESLNDLFSLVK
HHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNAMYGGTCINIGCIPTKTLVHDAQQ
CCCEEEEEEEECCCCCEEEEEEECCCEEEEEEECCCCEECCEEEEECCCCCHHHHHHHHH
HTDFVRAIQRKNEVVNFLRNKNFHNLADMPNIDVIDGQAEFINNHSLRVHRPEGNLEIHG
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHCCCCEEEECCCCCEEEEC
EKIFINTGAQTVVPPIPGITTTPGVYDSTGLLNLKELPGHLGILGGGYIGVEFASMFANF
CEEEEECCCCEECCCCCCCCCCCCCCCCCCCEEHHHCCCCEEEECCCCHHHHHHHHHHHC
GSKVTILEAASLFLPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQ
CCEEEEEEHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCEEEEHHHHH
LAVDALLIASGRQPATASLHPENAGIAVNERGAIVVDKQLHTTADNIWAMGDVTGGLQFT
HHHHHHEEECCCCCCEEECCCCCCCEEECCCCCEEECCCHHCCCCCEEEEECCCCCEEEE
YISLDDYRIVRDELLGEGRRSTDDRKNVPYSVFMTPPLSRVGMTEEQARESGADIQVVTL
EEECCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHCCCHHHHHHCCCCEEEEEE
PVAAIPRARVMNDTRGVLKAIVDNKTQRILGASLLCVDSHEMINIVKMVMDAGLPYSILR
CHHHCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEEEECCHHHHHHHHHHHHCCCCHHHHH
DQIFTHPSMSESLNDLFSLVK
HHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]