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The map label for this gene is fixC [H]

Identifier: 157159514

GI number: 157159514

Start: 47440

End: 48726

Strand: Direct

Name: fixC [H]

Synonym: EcHS_A0049

Alternate gene names: 157159514

Gene position: 47440-48726 (Clockwise)

Preceding gene: 157159513

Following gene: 157159515

Centisome position: 1.02

GC content: 55.01

Gene sequence:

>1287_bases
ATGTCCGAAGATATCTTTGACGCCATCATCGTCGGTGCTGGGCTTGCCGGTTCGGTTGCCGCACTGGTGCTCGCCCGCGA
AGGGGCGCAAGTGTTAGTTATCGAGCGTGGCAATTCCGCAGGTGCCAAGAACGTCACCGGCGGGCGTCTCTATGCCCACA
GCCTGGAACACATTATTCCTGGTTTCGCCGACTCCGCCCCCGTAGAACGCCTGATCACCCATGAAAAACTCGCGTTTATG
ACGGAAAAGTCAGCGATGACTATGGACTACTGCAATGGTGACGAAACCTCGCCATCCCAGCGTTCTTACTCCGTTTTGCG
CAGTAAATTTGATGCCTGGCTGATGGAGCAGGCCGAAGAAGCGGGCGCGCAGTTAATTACCGGGATCCGCGTCGATAACC
TCGTACAGCGCGATGGCAAAGTCGTCGGTGTAGAAGCCGATGGCGATGTGATTGAAGCGAAAACGGTGATCCTTGCTGAT
GGAGTGAACTCCATCCTTGCCGAAAAGCTGGGGATGGCAAAACGCGTTAAACCGACGGATGTGGCGGTTGGCGTGAAGGA
ACTGATCGAGTTACCGAAGTCGGTAATCGAAGACCGTTTTCAGTTGCAGGGTAATCAGGGCGCGGCTTGTCTGTTTGCGG
GATCACCCACCGATGGCCTGATGGGCGGCGGCTTCCTTTATACCAATGAAAATACCCTGTCGCTGGGGCTGGTTTGTGGT
CTGCATCATCTGCATGACGCAAAAAAATCGGTGCCGCAAATGCTGGAAGATTTCAAACAACATCCGGCCGTTGCACCGCT
GATCGCGGGTGGCAAGCTGGTGGAATATTCCGCTCACGTAGTGCCGGAAGCAGGCATCAACATGCTGCCGGAGTTGGTTG
GTGACGGCGTATTGATTGCCGGTGATGCCGCCGGAATGTGTATGAACCTCGGTTTTACCATTCGCGGTATGGATCTGGCG
ATTGCCGCCGGGGAAGCCGCAGCAAAAACCGTGCTTTCAGCGATGAAAAGCGACGATTTCAGTAAGCAAAAACTGGCGGA
ATATCGTCAGCATCTTGAGAGTGGCCCGCTGCGCGATATGCGTATGTACCAGAAACTACCGGCCTTCCTTGATAACCCAC
GCATGTTTAGCGGCTACCCGGAACTGGCGGTGGGCGTGGCGCGTGACCTGTTCACCATTGACGGCAGTGCGCCGGAACTG
ATGCGCAAGAAAATCCTCCGCCACGGCAAGAAAGTGGGCTTCATCAATCTGATCAAGGATGGCATGAAAGGAGTGACCGT
TTTATGA

Upstream 100 bases:

>100_bases
GTGACGCCGTGAAGATCCTTCCGGCGCTGACCGCAGCTTTAGCGCGTTGATCCACTCTGGCAGGGCTGCATTTTGGCCCT
GCCGCTGACAGGGAGCTCTT

Downstream 100 bases:

>100_bases
CTTCTCCCGTCAATGTGGACGTCAAACTGGGCGTCAATAAATTCAATGTCGATGAAGAGCATCCGCACATTGTTGTGAAG
GCCGATGCCGATAAACAGGC

Product: putative oxidoreductase FixC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFM
TEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILAD
GVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
IAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPEL
MRKKILRHGKKVGFINLIKDGMKGVTVL

Sequences:

>Translated_428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFM
TEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILAD
GVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
IAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPEL
MRKKILRHGKKVGFINLIKDGMKGVTVL
>Mature_427_residues
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFMT
EKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADG
VNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCGL
HHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAI
AAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELM
RKKILRHGKKVGFINLIKDGMKGVTVL

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=384, Percent_Identity=26.8229166666667, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786227, Length=428, Percent_Identity=100, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1787991, Length=429, Percent_Identity=61.3053613053613, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI87082155, Length=428, Percent_Identity=40.4205607476636, Blast_Score=318, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI25144720, Length=398, Percent_Identity=25.6281407035176, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324932, Length=376, Percent_Identity=27.1276595744681, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24652256, Length=365, Percent_Identity=28.2191780821918, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: NA

Molecular weight: Translated: 45703; Mature: 45572

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIP
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADSAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTD
HHHHHHHCCHHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHCCCCHH
VAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEHHHHHH
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
GDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
RMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKD
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
GMKGVTVL
CCCCCCCC
>Mature Secondary Structure 
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIP
CHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFADSAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEE
CCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTD
HHHHHHHCCHHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHCCCCHH
VAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEHHHHHH
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
GDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQHLESGPLRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
RMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKD
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
GMKGVTVL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]