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The map label for this gene is atoB [H]

Identifier: 157156337

GI number: 157156337

Start: 1663306

End: 1664511

Strand: Reverse

Name: atoB [H]

Synonym: EcE24377A_1668

Alternate gene names: 157156337

Gene position: 1664511-1663306 (Counterclockwise)

Preceding gene: 157157143

Following gene: 157155775

Centisome position: 33.43

GC content: 55.89

Gene sequence:

>1206_bases
ATGCAGGACGTTGTTATTGTTGCCGCTACGCGCACACCGATTGGCTGTTTTCATGGCGCTCTCGCCCCACTTTCTGCGGT
TGATCTCGGTGCTGCCACCATCCGTTCGTTGCTGGAGAAAACCGCACTTGCAGCAGAACAGATCGACGAAGTGATTTTTG
GTCAGGTCCTGACCGCCGGAAGCGGACAAAACCCGGCACGACAATCGGCGCTCAAAGCCGGGTTAAGCCACAATACACCC
GCCGTTACCATCAACCTGGTATGTGGTTCCGGTCTGAAAGCCGTACACCAGGCAGTGCAGGCGATCCGTTGCGGTGATGC
ACAGATAATTATCGCAGGTGGCCAGGAAAGCATGAGCAACGCGCCCTATTTTATTGATGGCGCGCGGGCAGGTTTACGCC
TCGGGCATACCAGCATGAAAGACAGCGTGGTTCATGACGGACTATGGGATGCTTTCAATGATTACCACATGGGCATTACT
GCAGAAAACCTGGCGCAAAAATATGCCATCAGTCGCGAGCGACAGGACACATTCGCGCTACGTTCTCAGCAAAAAGCCGC
TGCCGCAATGGAAGCCGGGCGCTTTGCAGACGAAATTACTCCGGTGAGCGTACCACAAGGTAAAAAACCACCACGCTGGG
TAAATACCGACGAACAACCACGTTCCGGGACGCAACTGGAAAAACTAGCGCAACTGAAACCGGCCTTTCTTCCGGGGGCG
GGAAGCGTCACCGCAGGAAATGCCTCTTCCATTAATGATGGTGCCGCCGCAGTCATGTTAATGCGCGCCAGCAAAGCTGC
TGAACTGGGCCTCCCAGTGCTGGCTCGGGTGGCAGGTTATGCCGTTTCTGGCGTCGCTCCTGCCTTTATGGGCATTGGTC
CGGTCGCCGCTACCCGCGAATGTCTTAAGCGTTGCGGATGGACGCTGGAAGATATTGATCTTATTGAAGCCAACGAGGCT
TTCGCAGCGCAGGCGCTGGCCGTTGGCGACGAACTGAACTGGGATTGCGACAAAGTGAATGTTAACGGCGGCGCAATCGC
ACTTGGGCATCCTATTGGCGCTTCCGGTTGCCGCATTCTGGTCACTCTCATTTATGAAATGGCGCGACGTAATGCGCAAA
AAGGGCTGGCGACGCTGTGCGTCGGTGGCGGTCAGGGCGTGGCGCTGACACTGGAAAGAACCACAGGAGAACACCATGCA
AACTGA

Upstream 100 bases:

>100_bases
CGCGCCGGGAATCAGCGTTGCGGAAATCATCGCCAAAACCGCCGGTAAGTTGTTTGTGCCGGAACATGTCCCGGAAATGC
AATTCAACTGAGGAATCACC

Downstream 100 bases:

>100_bases
ACAATTTGCGGTACTGGGCGCCGGATTGATGGGCGTGGGGATTGCCACTCATTTCGCCCGCTTTGGTCATGATATCTGGC
TGTACGATACCGAGCAGAGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQDVVIVAATRTPIGCFHGALAPLSAVDLGAATIRSLLEKTALAAEQIDEVIFGQVLTAGSGQNPARQSALKAGLSHNTP
AVTINLVCGSGLKAVHQAVQAIRCGDAQIIIAGGQESMSNAPYFIDGARAGLRLGHTSMKDSVVHDGLWDAFNDYHMGIT
AENLAQKYAISRERQDTFALRSQQKAAAAMEAGRFADEITPVSVPQGKKPPRWVNTDEQPRSGTQLEKLAQLKPAFLPGA
GSVTAGNASSINDGAAAVMLMRASKAAELGLPVLARVAGYAVSGVAPAFMGIGPVAATRECLKRCGWTLEDIDLIEANEA
FAAQALAVGDELNWDCDKVNVNGGAIALGHPIGASGCRILVTLIYEMARRNAQKGLATLCVGGGQGVALTLERTTGEHHA
N

Sequences:

>Translated_401_residues
MQDVVIVAATRTPIGCFHGALAPLSAVDLGAATIRSLLEKTALAAEQIDEVIFGQVLTAGSGQNPARQSALKAGLSHNTP
AVTINLVCGSGLKAVHQAVQAIRCGDAQIIIAGGQESMSNAPYFIDGARAGLRLGHTSMKDSVVHDGLWDAFNDYHMGIT
AENLAQKYAISRERQDTFALRSQQKAAAAMEAGRFADEITPVSVPQGKKPPRWVNTDEQPRSGTQLEKLAQLKPAFLPGA
GSVTAGNASSINDGAAAVMLMRASKAAELGLPVLARVAGYAVSGVAPAFMGIGPVAATRECLKRCGWTLEDIDLIEANEA
FAAQALAVGDELNWDCDKVNVNGGAIALGHPIGASGCRILVTLIYEMARRNAQKGLATLCVGGGQGVALTLERTTGEHHA
N
>Mature_401_residues
MQDVVIVAATRTPIGCFHGALAPLSAVDLGAATIRSLLEKTALAAEQIDEVIFGQVLTAGSGQNPARQSALKAGLSHNTP
AVTINLVCGSGLKAVHQAVQAIRCGDAQIIIAGGQESMSNAPYFIDGARAGLRLGHTSMKDSVVHDGLWDAFNDYHMGIT
AENLAQKYAISRERQDTFALRSQQKAAAAMEAGRFADEITPVSVPQGKKPPRWVNTDEQPRSGTQLEKLAQLKPAFLPGA
GSVTAGNASSINDGAAAVMLMRASKAAELGLPVLARVAGYAVSGVAPAFMGIGPVAATRECLKRCGWTLEDIDLIEANEA
FAAQALAVGDELNWDCDKVNVNGGAIALGHPIGASGCRILVTLIYEMARRNAQKGLATLCVGGGQGVALTLERTTGEHHA
N

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=50.6393861892583, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI167614485, Length=399, Percent_Identity=43.859649122807, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.765903307888, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=41.3098236775819, Blast_Score=258, Evalue=7e-69,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=33.5680751173709, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=30.7304785894207, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=65.9033078880407, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=57.1065989847716, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=45.273631840796, Blast_Score=297, Evalue=7e-82,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=44.4168734491315, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=34.6604215456674, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=44.1326530612245, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=39.6946564885496, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=37.6288659793814, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=33.7236533957845, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=30.9823677581864, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=43.4673366834171, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6322031, Length=392, Percent_Identity=39.2857142857143, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=53.1645569620253, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.2225063938619, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=43.2569974554707, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=32.6340326340326, Blast_Score=191, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41706; Mature: 41706

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDVVIVAATRTPIGCFHGALAPLSAVDLGAATIRSLLEKTALAAEQIDEVIFGQVLTAG
CCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGQNPARQSALKAGLSHNTPAVTINLVCGSGLKAVHQAVQAIRCGDAQIIIAGGQESMSN
CCCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHCCC
APYFIDGARAGLRLGHTSMKDSVVHDGLWDAFNDYHMGITAENLAQKYAISRERQDTFAL
CCEEEECCCCCEEECCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSQQKAAAAMEAGRFADEITPVSVPQGKKPPRWVNTDEQPRSGTQLEKLAQLKPAFLPGA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GSVTAGNASSINDGAAAVMLMRASKAAELGLPVLARVAGYAVSGVAPAFMGIGPVAATRE
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
CLKRCGWTLEDIDLIEANEAFAAQALAVGDELNWDCDKVNVNGGAIALGHPIGASGCRIL
HHHHHCCCCHHCEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHH
VTLIYEMARRNAQKGLATLCVGGGQGVALTLERTTGEHHAN
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MQDVVIVAATRTPIGCFHGALAPLSAVDLGAATIRSLLEKTALAAEQIDEVIFGQVLTAG
CCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SGQNPARQSALKAGLSHNTPAVTINLVCGSGLKAVHQAVQAIRCGDAQIIIAGGQESMSN
CCCCHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHCCC
APYFIDGARAGLRLGHTSMKDSVVHDGLWDAFNDYHMGITAENLAQKYAISRERQDTFAL
CCEEEECCCCCEEECCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSQQKAAAAMEAGRFADEITPVSVPQGKKPPRWVNTDEQPRSGTQLEKLAQLKPAFLPGA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
GSVTAGNASSINDGAAAVMLMRASKAAELGLPVLARVAGYAVSGVAPAFMGIGPVAATRE
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
CLKRCGWTLEDIDLIEANEAFAAQALAVGDELNWDCDKVNVNGGAIALGHPIGASGCRIL
HHHHHCCCCHHCEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCCCCHHHHH
VTLIYEMARRNAQKGLATLCVGGGQGVALTLERTTGEHHAN
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]