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The map label for this gene is hbd [H]

Identifier: 157155775

GI number: 157155775

Start: 1662393

End: 1663316

Strand: Reverse

Name: hbd [H]

Synonym: EcE24377A_1667

Alternate gene names: 157155775

Gene position: 1663316-1662393 (Counterclockwise)

Preceding gene: 157156337

Following gene: 157158663

Centisome position: 33.4

GC content: 54.44

Gene sequence:

>924_bases
ATGCAAACTGAACAATTTGCGGTACTGGGCGCCGGATTGATGGGCGTGGGGATTGCCACTCATTTCGCCCGCTTTGGTCA
TGATATCTGGCTGTACGATACCGAGCAGAGCCGGATTGCAGAAATCCACGTAGTTGCAGGCGGAATTCTTGATGAGCTGA
TTAGCTGCGAACAGTTTACTGCCCCGGAAAAAGAGAATGTGCTTAAACGTCTGCACGGCACGACTTCTCTTGCAGACATC
GCCGACTCGCAACTACTGATTGAGGCGATCCCGGAGCGACTTGAACTAAAACACGCATTATATACCGAGCTTGAAACGCT
TATTTCTCCTGAGGCCATTGTCGCCAGCAATACCAGCGGTCTGCCGCCCGATGATCTGGCCGCGAAGATGCGCTACCCGC
AACGACTGCTGATCGCCCATTTCTGGCATCCGCCGCACTTCATTCCACTTGTGGAGATTATCCCCGGCAGCGTTACCGAG
CCAAAGCATTTGCACTGGCTGCAACACTTGCTTGTGTCACTGCAACTGGAAGCAGTGTTGCTGGATCGCGCTGCGCCAGG
ATTTGTCGGCAACCGTCTGCAATTTGCACTGTTGCGTGAAGCCCTGCATATCGTAAAAAGCGGCATCGCCAGTGCAGAAG
TGGTGGATCAGGTGATGCGCGCCTCGCTTGGGCGACGTTATGCCATGGTCGGCCCGCTGGAGGCCGCCGACATGACCGGA
CTTTCGACGGTGCAGGATATTTGTCGCCATCTGCTCCCTGAACTAGCGACTGGCAGCGACATGATGTCATTAGTTGCCGA
AAAAGTGGAACGTGGAGACATCGGCGTACGTAGCGGTCAGGGATTTTACTGCTGGGATGAATCGCGGAAGCAGTACATCC
AGCAGCGTCGGGAACATCAACTTCGCTTCGCCCTTAAACCATAA

Upstream 100 bases:

>100_bases
GAAATGGCGCGACGTAATGCGCAAAAAGGGCTGGCGACGCTGTGCGTCGGTGGCGGTCAGGGCGTGGCGCTGACACTGGA
AAGAACCACAGGAGAACACC

Downstream 100 bases:

>100_bases
CTTCTCTCGCTGTACCCACTATAACAACGATATTGAGGAGTCCCGATGAGTGTATTAATCGCCCTTGCCGCGCTTGGGCT
GCTAATGCTGGCAGCCTATC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MQTEQFAVLGAGLMGVGIATHFARFGHDIWLYDTEQSRIAEIHVVAGGILDELISCEQFTAPEKENVLKRLHGTTSLADI
ADSQLLIEAIPERLELKHALYTELETLISPEAIVASNTSGLPPDDLAAKMRYPQRLLIAHFWHPPHFIPLVEIIPGSVTE
PKHLHWLQHLLVSLQLEAVLLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTG
LSTVQDICRHLLPELATGSDMMSLVAEKVERGDIGVRSGQGFYCWDESRKQYIQQRREHQLRFALKP

Sequences:

>Translated_307_residues
MQTEQFAVLGAGLMGVGIATHFARFGHDIWLYDTEQSRIAEIHVVAGGILDELISCEQFTAPEKENVLKRLHGTTSLADI
ADSQLLIEAIPERLELKHALYTELETLISPEAIVASNTSGLPPDDLAAKMRYPQRLLIAHFWHPPHFIPLVEIIPGSVTE
PKHLHWLQHLLVSLQLEAVLLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTG
LSTVQDICRHLLPELATGSDMMSLVAEKVERGDIGVRSGQGFYCWDESRKQYIQQRREHQLRFALKP
>Mature_307_residues
MQTEQFAVLGAGLMGVGIATHFARFGHDIWLYDTEQSRIAEIHVVAGGILDELISCEQFTAPEKENVLKRLHGTTSLADI
ADSQLLIEAIPERLELKHALYTELETLISPEAIVASNTSGLPPDDLAAKMRYPQRLLIAHFWHPPHFIPLVEIIPGSVTE
PKHLHWLQHLLVSLQLEAVLLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTG
LSTVQDICRHLLPELATGSDMMSLVAEKVERGDIGVRSGQGFYCWDESRKQYIQQRREHQLRFALKP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=33.0472103004292, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI296179429, Length=293, Percent_Identity=31.740614334471, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=27.0547945205479, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=27.0547945205479, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI20127408, Length=298, Percent_Identity=27.8523489932886, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI296179427, Length=310, Percent_Identity=30, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787661, Length=307, Percent_Identity=30.6188925081433, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1788682, Length=240, Percent_Identity=30.8333333333333, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790281, Length=293, Percent_Identity=25.938566552901, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17549919, Length=300, Percent_Identity=28.3333333333333, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=292, Percent_Identity=27.7397260273973, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=292, Percent_Identity=27.7397260273973, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508951, Length=292, Percent_Identity=27.7397260273973, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=27.8745644599303, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17558304, Length=294, Percent_Identity=26.8707482993197, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=25.3571428571429, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=27.5510204081633, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI115533614, Length=178, Percent_Identity=33.1460674157303, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193203623, Length=178, Percent_Identity=33.1460674157303, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985930, Length=294, Percent_Identity=24.8299319727891, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549573, Length=250, Percent_Identity=33.2, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI20129993, Length=270, Percent_Identity=32.962962962963, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19921000, Length=296, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24583077, Length=296, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24583079, Length=296, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34184; Mature: 34184

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTEQFAVLGAGLMGVGIATHFARFGHDIWLYDTEQSRIAEIHVVAGGILDELISCEQFT
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
APEKENVLKRLHGTTSLADIADSQLLIEAIPERLELKHALYTELETLISPEAIVASNTSG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
LPPDDLAAKMRYPQRLLIAHFWHPPHFIPLVEIIPGSVTEPKHLHWLQHLLVSLQLEAVL
CCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHCCC
LSTVQDICRHLLPELATGSDMMSLVAEKVERGDIGVRSGQGFYCWDESRKQYIQQRREHQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHH
LRFALKP
HHCCCCC
>Mature Secondary Structure
MQTEQFAVLGAGLMGVGIATHFARFGHDIWLYDTEQSRIAEIHVVAGGILDELISCEQFT
CCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
APEKENVLKRLHGTTSLADIADSQLLIEAIPERLELKHALYTELETLISPEAIVASNTSG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
LPPDDLAAKMRYPQRLLIAHFWHPPHFIPLVEIIPGSVTEPKHLHWLQHLLVSLQLEAVL
CCHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTG
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHCCC
LSTVQDICRHLLPELATGSDMMSLVAEKVERGDIGVRSGQGFYCWDESRKQYIQQRREHQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHH
LRFALKP
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]