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The map label for this gene is prc [H]

Identifier: 157155122

GI number: 157155122

Start: 2040365

End: 2042413

Strand: Reverse

Name: prc [H]

Synonym: EcE24377A_2059

Alternate gene names: 157155122

Gene position: 2042413-2040365 (Counterclockwise)

Preceding gene: 157159080

Following gene: 157156002

Centisome position: 41.02

GC content: 50.71

Gene sequence:

>2049_bases
ATGAACATGTTTTTTAGGCTTACCGCGTTAGCTGGCCTGCTTGCAATAGCAGGCCAGACCTTCGCTGTAGAAGATATCAC
GCGTGCTGATCAAATTCCGGTATTAAAGGAAGAGACGCAGCATGCGACGGTAAGTGAGCGCGTAACGTCGCGCTTCACCC
GTTCTCATTATCGCCAGTTCGACCTCGATCAGGCATTTTCGGCCAAAATCTTTGACCGCTACCTGAATCTGCTCGATTAC
AGCCACAACGTGCTGCTGGCAAGCGATGTTGAACAGTTCGCGAAAAAGAAAACCGAGTTAGGCGATGAACTGCGTTCAGG
CAAACTCGACGTTTTCTACGATCTCTACAATCTGGCGCAAAAGCGCCGTTTTGAGCGTTACCAGTACGCTTTGTCGGTAC
TGGAAAAGCCGATGGATTTCACCGGCAACGACACTTATAACCTTGACCGCAGCAAAGCGCCCTGGCCGAAAAACGAGGCT
GAGTTGAACGCGCTGTGGGACAGTAAAGTCAAATTCGACGAGTTAAGCCTGAAGCTGGCAGGAAAAACGGATAAAGAAAT
TCGTGAAACCCTGACACGCCGCTACAAATTTGCCATTCGTCGTCTGGCGCAAACCAACAGCGAAGATGTTTTCTCGCTGG
CAATGACGGCGTTTGCGCGTGAAATCGACCCGCATACCAACTATCTTTCCCCGCGTAATACCGAACAGTTCAACACTGAA
ATGAGTTTGTCGCTGGAAGGTATTGGCGCAGTGCTGCAAATGGATGATGACTACACCGTTATCAATTCGATGGTGGCAGG
TGGTCCGGCAGCGAAGAGTAAAGCTATCAGCGTTGGTGACAAAATTGTCGGTGTTGGTCAAACAGGCAAGCCGATGGTTG
ACGTGATTGGCTGGCGTCTTGATGATGTGGTTGCCTTAATTAAAGGGCCGAAGGGCAGTAAAGTTCGTCTGGAAATTTTA
CCTGCTGGTAAAGGGACCAAGACCCGCACTGTAACATTGACCCGTGAACGTATTCGTCTCGAAGACCGCGCGGTTAAAAT
GTCGGTGAAGACCGTCGGTAAAGAGAAAGTCGGCGTGCTGGATATTCCGGGCTTCTATGTGGGTTTGACAGACGATGTCA
AAGTTCAACTGCAGAAACTGGAAAAACAGAATGTCAGCAGTGTGATCATCGACCTGCGTAGCAATGGCGGTGGGGCGCTG
ACCGAAGCGGTATCGCTCTCAGGTCTGTTTATTCCTGCGGGTCCCATTGTTCAGGTCCGCGATAACAACGGCAAGGTTCG
TGAAGACAGCGATACCGACGGGCAGGTGTTCTATAAAGGCCCGCTGGTGGTACTGGTTGACCGTTTCAGTGCTTCGGCTT
CAGAAATCTTTGCCGCGGCAATGCAGGATTACGGTCGTGCGCTGGTTGTGGGTGAACCGACGTTTGGTAAAGGCACCGTT
CAGCAATACCGTTCATTGAACCGTATTTACGATCAGATGTTACGTCCTGAATGGCCAGCGCTGGGTTCTGTGCAGTACAC
GATCCAGAAATTCTATCGCGTTAACGGCGGCAGTACGCAACGTAAAGGCGTAACGCCAGACATCATCATGCCGACGGGTA
ATGAAGAAACGGAAACGGGTGAGAAATTCGAAGATAACGCGCTGCCGTGGGATAGCATTGATGCCGCGACTTATGTGAAA
TCAGGCGATTTAACGGCCTTTGGGCCGGAGCTGCTGAAGGAACATAATGCGCGTATCGCGAAAGATCCTGAGTTCCAGAA
CATCATGAAGGATATCGCGCGCTTCAACGCTATGAAGGACAAGCGCAATATCGTTTCTCTGAACTACGCTGTGCGTGAGA
AAGAGAATAATGAAGATGATGCGACGCGTCTGGCGCGTTTGAACGAACGCTTTAAACGCGAAGGTAAACCGGAGTTGAAG
AAGCTGGATGATCTACCTAAAGATTACCAGGCGCCGGATCCTTATCTGGATGAGACGGTGAATATCGCACTCGATCTGGC
GAAGCTTGAAAAAGCCAGACCCGCGGAACAACCCGCTCCCGTCAAGTAA

Upstream 100 bases:

>100_bases
GAAATCACCAAAGACGGCGTCCGCGTCCAGCTGAATTCGGGTATGTCTTTGATTGTGCGCGCAGAACACCTGGTGTTCTG
AAACGGAGGCCGGGCCAGGC

Downstream 100 bases:

>100_bases
TATCAATCAGGCACAAGAAATTGTGCCTGATTTTTTAACAGCGGCAAGATGCCGTAAATCAGATGCTACAAAATGTAAAG
TTGTGTCTTTCTGGTGACTT

Product: carboxy-terminal protease

Products: NA

Alternate protein names: C-terminal-processing peptidase; PRC protein; Protease Re [H]

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDY
SHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEA
ELNALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEIL
PAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGAL
TEAVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVK
SGDLTAFGPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELK
KLDDLPKDYQAPDPYLDETVNIALDLAKLEKARPAEQPAPVK

Sequences:

>Translated_682_residues
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDY
SHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEA
ELNALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEIL
PAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGAL
TEAVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVK
SGDLTAFGPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELK
KLDDLPKDYQAPDPYLDETVNIALDLAKLEKARPAEQPAPVK
>Mature_682_residues
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQFDLDQAFSAKIFDRYLNLLDY
SHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQKRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEA
ELNALWDSKVKFDELSLKLAGKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRLDDVVALIKGPKGSKVRLEIL
PAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVLDIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGAL
TEAVSLSGLFIPAGPIVQVRDNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETGEKFEDNALPWDSIDAATYVK
SGDLTAFGPELLKEHNARIAKDPEFQNIMKDIARFNAMKDKRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELK
KLDDLPKDYQAPDPYLDETVNIALDLAKLEKARPAEQPAPVK

Specific function: Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses [H]

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=682, Percent_Identity=99.5601173020528, Blast_Score=1387, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR020992 [H]

Pfam domain/function: PF11818 DUF3340; PF00595 PDZ; PF03572 Peptidase_S41 [H]

EC number: =3.4.21.102 [H]

Molecular weight: Translated: 76504; Mature: 76504

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQF
CCHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DLDQAFSAKIFDRYLNLLDYSHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQ
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAELNALWDSKVKFDELSLKLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEHEEEEEC
GKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRL
EEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCHHHHHCCCH
DDVVALIKGPKGSKVRLEILPAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVL
HHHHHHHCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHEEHHHHCCCCCCCEE
DIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTEAVSLSGLFIPAGPIVQVR
ECCCEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCEEEECCCCEEEEE
DNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
CCCCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHH
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCC
EKFEDNALPWDSIDAATYVKSGDLTAFGPELLKEHNARIAKDPEFQNIMKDIARFNAMKD
CCCCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
KRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKLDDLPKDYQAPDPYLDETV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHH
NIALDLAKLEKARPAEQPAPVK
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQF
CCHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DLDQAFSAKIFDRYLNLLDYSHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQ
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAELNALWDSKVKFDELSLKLA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEHEEEEEC
GKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRL
EEEEECCCCEEEEECCCHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCHHHHHCCCH
DDVVALIKGPKGSKVRLEILPAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVL
HHHHHHHCCCCCCEEEEEEEECCCCCCEEEEEEEHHHHHHHHHHHEEHHHHCCCCCCCEE
DIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTEAVSLSGLFIPAGPIVQVR
ECCCEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCEEEECCCCEEEEE
DNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
CCCCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCCCHHH
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETG
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCC
EKFEDNALPWDSIDAATYVKSGDLTAFGPELLKEHNARIAKDPEFQNIMKDIARFNAMKD
CCCCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
KRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKLDDLPKDYQAPDPYLDETV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHH
NIALDLAKLEKARPAEQPAPVK
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1856173; 1729701; 9097040; 9278503; 1447154; 10049386; 7499412; 8576225 [H]