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The map label for this gene is lrp [H]

Identifier: 156978107

GI number: 156978107

Start: 2009702

End: 2010217

Strand: Reverse

Name: lrp [H]

Synonym: VIBHAR_06912

Alternate gene names: 156978107

Gene position: 2010217-2009702 (Counterclockwise)

Preceding gene: 156978111

Following gene: 156978104

Centisome position: 91.21

GC content: 45.35

Gene sequence:

>516_bases
ATGATAGGTAGAAGTGACATCAATTTTGTGCTTTTATTTGATGAAAATACGCCAGATAAACAACAAAAGGTCACCATGGA
TAGATTTGACGAAAGAATATTGCAAGTGCTGAAATCAGACGGAAGAATCTCCAATGTGGAGTTGTCTGAACGTGTTGGAT
TGTCACCATCGGCGACCTTACGTCGTGTGCAAGATTTGGAGCGTAAAGGGATCATCAAAGGCTATCGAGCCGTGTTAGAT
AATCAGCAAATGGGTGTTGGTTTTGTTGCTTATGTCTCGATTGGTCTGGCTTCTCACTCCAAGCAGGCCCAGCTTGGTTT
TGAAGATCACGTGCGCTTTGTTGACGAGGTAGTGGAATGCCACAATATCACTGGAGCGAACGAATATTTGTTACGAGTGG
AAACCCAAGATCTTGCAGCATACAAAGCCTTCCATGCCGATGTATTGGGAGAGTGCGAGCACGTCAAGGCGATCACGACC
ATGGTGGTGATGGATACGCCCAAAGACGAGCGTTAA

Upstream 100 bases:

>100_bases
CAGCGCACCAAGTTGATGGTATTCCATAGTGTTTTCCTGCATTTTTGTTTTGCCTGCGTGCACTCAAGCGAAAGAGAGTT
GTCTTGACTAGTCGTGAACA

Downstream 100 bases:

>100_bases
TCCTTTTCCTTCGATTTTGTAGCACATCAATTTGAAGTGACTCGAAAGAGTCAGTCGAGTATGAGCAAAGTCCACACAAA
ATGCTGGAAAGCAGTCTGCA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MIGRSDINFVLLFDENTPDKQQKVTMDRFDERILQVLKSDGRISNVELSERVGLSPSATLRRVQDLERKGIIKGYRAVLD
NQQMGVGFVAYVSIGLASHSKQAQLGFEDHVRFVDEVVECHNITGANEYLLRVETQDLAAYKAFHADVLGECEHVKAITT
MVVMDTPKDER

Sequences:

>Translated_171_residues
MIGRSDINFVLLFDENTPDKQQKVTMDRFDERILQVLKSDGRISNVELSERVGLSPSATLRRVQDLERKGIIKGYRAVLD
NQQMGVGFVAYVSIGLASHSKQAQLGFEDHVRFVDEVVECHNITGANEYLLRVETQDLAAYKAFHADVLGECEHVKAITT
MVVMDTPKDER
>Mature_171_residues
MIGRSDINFVLLFDENTPDKQQKVTMDRFDERILQVLKSDGRISNVELSERVGLSPSATLRRVQDLERKGIIKGYRAVLD
NQQMGVGFVAYVSIGLASHSKQAQLGFEDHVRFVDEVVECHNITGANEYLLRVETQDLAAYKAFHADVLGECEHVKAITT
MVVMDTPKDER

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=40, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=28.6713286713287, Blast_Score=74, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19297; Mature: 19297

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRSDINFVLLFDENTPDKQQKVTMDRFDERILQVLKSDGRISNVELSERVGLSPSATL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHH
RRVQDLERKGIIKGYRAVLDNQQMGVGFVAYVSIGLASHSKQAQLGFEDHVRFVDEVVEC
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
HNITGANEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDTPKDER
HCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
>Mature Secondary Structure
MIGRSDINFVLLFDENTPDKQQKVTMDRFDERILQVLKSDGRISNVELSERVGLSPSATL
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHH
RRVQDLERKGIIKGYRAVLDNQQMGVGFVAYVSIGLASHSKQAQLGFEDHVRFVDEVVEC
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
HNITGANEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDTPKDER
HCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]