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The map label for this gene is cyoE2

Identifier: 156977477

GI number: 156977477

Start: 1446966

End: 1447880

Strand: Reverse

Name: cyoE2

Synonym: VIBHAR_06264

Alternate gene names: 156977477

Gene position: 1447880-1446966 (Counterclockwise)

Preceding gene: 156977478

Following gene: 156977474

Centisome position: 65.69

GC content: 45.68

Gene sequence:

>915_bases
ATGAGTAAAGAAATCGCGTTACCTCTAGAAAGTGGTAAGAAAAAGATTGGTTCAACCTATTTAAAACTGACAAAGCCTAA
AGTGGTCGCCCTAATGCTTATCACAGCAGTTGTTGGTATGAGCTTGGCCCCAGTCGTTGACTTCCCATGGCTACAAGCTG
CGTTCGGTCTCGTTGGCATTGGTTTGATGGCGGGGTCGGCGGCAGCGTTTAATCATCTCATCGACCGACGTATTGATGCG
CGTATGGCTCGAACGCACAAACGACCATTGCCTTCGGGCGATACCAACCCTATATCTGTCGCGATTTTTTCTACTGCTTT
GGGTGTGATTGGTTTTGTGTTGCTTTATGCCTTGGTTAATCCACTGACAGCATGGATGACTTTCTTAAGTTTGCTAGGCT
ATGCGGTGGTTTATACCATGTACCTAAAGCGAGCAACGCCGCAAAACATTGTGATTGCGGGAATTGCAGGTGCAATGCCA
CCACTACTTGGTTGGACGGCTGTAACCGGAGAACTGCACGCCCATGCTTGGCTACTGGTGATGATTATCTTTATTTGGAC
ACCACCACATTTTTGGGCGATCGCGATTCATCGCGTCGAAGACTATCGAAAAGTGGATATCCCGATGCTCCCTGTGACTC
ATGGCATTGAATACACCAAAACTTCGATTCTTCTTTACACGATACTACTCACACTTGTTTGTATTCTTCCTGTGCTGGTG
GGTATGGTTGGCTCGGTTTATCTTTTTTCGTCGCTGCTTCTCAATGCAGGTTTTATGTATCACGCTTGGAAATTGAAGTT
ATCTCCTGAGCAGAACAGCGCGATGGAAACCTTTAAATTCTCCATTTATCACTTACTCGCTTTGTTTGTTGCTTTGTTAG
CGGATCATTATCTTGGTCTGTTCTTCACGCCATAA

Upstream 100 bases:

>100_bases
AATCTCGGTGCAGCCATCATGCTTACACTTATCTGCGTTAGTCAGTTCTATCTATGGCAAGGTAAGGCTTATTGGAGTCA
TCAAGCGAAAGGAGTTCGCT

Downstream 100 bases:

>100_bases
AAGCCGTTTAGCTGTTGTTTCAAACCGCACTGATTAGGTGCGGTTTTTTGTTGGCGTATATATCGAAAATTACTTTGCTG
ACTAACTCTTAGCGGTGCGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 2; Heme O synthase 2

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSKEIALPLESGKKKIGSTYLKLTKPKVVALMLITAVVGMSLAPVVDFPWLQAAFGLVGIGLMAGSAAAFNHLIDRRIDA
RMARTHKRPLPSGDTNPISVAIFSTALGVIGFVLLYALVNPLTAWMTFLSLLGYAVVYTMYLKRATPQNIVIAGIAGAMP
PLLGWTAVTGELHAHAWLLVMIIFIWTPPHFWAIAIHRVEDYRKVDIPMLPVTHGIEYTKTSILLYTILLTLVCILPVLV
GMVGSVYLFSSLLLNAGFMYHAWKLKLSPEQNSAMETFKFSIYHLLALFVALLADHYLGLFFTP

Sequences:

>Translated_304_residues
MSKEIALPLESGKKKIGSTYLKLTKPKVVALMLITAVVGMSLAPVVDFPWLQAAFGLVGIGLMAGSAAAFNHLIDRRIDA
RMARTHKRPLPSGDTNPISVAIFSTALGVIGFVLLYALVNPLTAWMTFLSLLGYAVVYTMYLKRATPQNIVIAGIAGAMP
PLLGWTAVTGELHAHAWLLVMIIFIWTPPHFWAIAIHRVEDYRKVDIPMLPVTHGIEYTKTSILLYTILLTLVCILPVLV
GMVGSVYLFSSLLLNAGFMYHAWKLKLSPEQNSAMETFKFSIYHLLALFVALLADHYLGLFFTP
>Mature_303_residues
SKEIALPLESGKKKIGSTYLKLTKPKVVALMLITAVVGMSLAPVVDFPWLQAAFGLVGIGLMAGSAAAFNHLIDRRIDAR
MARTHKRPLPSGDTNPISVAIFSTALGVIGFVLLYALVNPLTAWMTFLSLLGYAVVYTMYLKRATPQNIVIAGIAGAMPP
LLGWTAVTGELHAHAWLLVMIIFIWTPPHFWAIAIHRVEDYRKVDIPMLPVTHGIEYTKTSILLYTILLTLVCILPVLVG
MVGSVYLFSSLLLNAGFMYHAWKLKLSPEQNSAMETFKFSIYHLLALFVALLADHYLGLFFTP

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=193, Percent_Identity=37.3056994818653, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786631, Length=281, Percent_Identity=35.5871886120996, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790473, Length=251, Percent_Identity=28.2868525896414, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=32.7137546468402, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325085, Length=290, Percent_Identity=28.9655172413793, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI19921064, Length=290, Percent_Identity=31.0344827586207, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE2_VIBHB (A7N6I9)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001448383.1
- STRING:   A7N6I9
- GeneID:   5558732
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_06264
- NMPDR:   fig|338187.4.peg.3710
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- ProtClustDB:   PRK04375
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33469; Mature: 33337

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a12a40c)-; HASH(0x1ab4a488)-; HASH(0x10a028c4)-; HASH(0x19b63914)-; HASH(0x1a100a20)-; HASH(0x1a80f870)-; HASH(0x1a6d1fbc)-; HASH(0x194ae758)-; HASH(0x19f08cc8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEIALPLESGKKKIGSTYLKLTKPKVVALMLITAVVGMSLAPVVDFPWLQAAFGLVGI
CCCCEECCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHH
GLMAGSAAAFNHLIDRRIDARMARTHKRPLPSGDTNPISVAIFSTALGVIGFVLLYALVN
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
PLTAWMTFLSLLGYAVVYTMYLKRATPQNIVIAGIAGAMPPLLGWTAVTGELHAHAWLLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCHHHHHHHHHH
MIIFIWTPPHFWAIAIHRVEDYRKVDIPMLPVTHGIEYTKTSILLYTILLTLVCILPVLV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMVGSVYLFSSLLLNAGFMYHAWKLKLSPEQNSAMETFKFSIYHLLALFVALLADHYLGL
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFTP
EECH
>Mature Secondary Structure 
SKEIALPLESGKKKIGSTYLKLTKPKVVALMLITAVVGMSLAPVVDFPWLQAAFGLVGI
CCCEECCHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHH
GLMAGSAAAFNHLIDRRIDARMARTHKRPLPSGDTNPISVAIFSTALGVIGFVLLYALVN
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
PLTAWMTFLSLLGYAVVYTMYLKRATPQNIVIAGIAGAMPPLLGWTAVTGELHAHAWLLV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHCCHHHHHHHHHH
MIIFIWTPPHFWAIAIHRVEDYRKVDIPMLPVTHGIEYTKTSILLYTILLTLVCILPVLV
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GMVGSVYLFSSLLLNAGFMYHAWKLKLSPEQNSAMETFKFSIYHLLALFVALLADHYLGL
HHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFTP
EECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA