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The map label for this gene is guaC [H]

Identifier: 156977437

GI number: 156977437

Start: 1405843

End: 1406886

Strand: Reverse

Name: guaC [H]

Synonym: VIBHAR_06224

Alternate gene names: 156977437

Gene position: 1406886-1405843 (Counterclockwise)

Preceding gene: 156977439

Following gene: 156977436

Centisome position: 63.83

GC content: 48.47

Gene sequence:

>1044_bases
ATGCGTATCGAACAAGAACTTAAGTTAGGTTTTAAAGATGTACTGTTTCGCCCGAAACGTTCAACCCTTAAGAGCCGTTC
TCAAGTAAATTTAACCCGCGATTTTACATTCAAGCACAGTGGCCGTCAATGGTCTGGTGTACCTGTAATTGCGGCGAACA
TGGATTCGGTTGGTAGCTTCGCAATGGCGAAAGCGCTAGCAGAGCATGGTGTAATGACTGCTGTTCACAAACACTACACA
GTAGAAGACTGGGCTGAGTTTGCGAATACAGCAGACAAAGCAACACTAAACAACGTTATGGTTTCTACCGGTACGTCTGA
AGCAGACTTCCAAAAAACCAAAGACATCATGGCGATCTCTGATGAGTTTATCTTCATCTGTATCGATATCGCGAACGGTT
ACTCAGAGCACCTAGTCGAGTACGTACAACGTGTACGTGCTGCATTCCCAGACAAAGTTATCTCTGCAGGTAACGTAGTA
ACTGGCGACATGTGTGAAGAGCTAATCCTAGCGGGCGCAGACATCGTGAAAGTGGGTATCGGCCCAGGTTCTGTATGTAC
TACACGTGTTAAAACAGGTGTTGGTTACCCGCAACTTTCTGCAATCATCGAGTGTGGTGACGCTGCACACGGCCTTGGCG
GCATGATCATCGGTGACGGTGGCTGTTCATGTGCGGGTGACGTTGCAAAAGCATTCGGCGGCGGCGCTGACTTTGTCATG
CTAGGCGGTATGCTTGCTGGCCACGAAGAGTCAGGCGGTGAAGTGATTGAGCAAGACGGCAAGCAGTTCATGAAATTCTA
CGGAATGTCTTCTAAGAGCGCGATGGACAAGCACTCTGGTGGTGTTGCTGGCTACCGTGCCGCTGAAGGTAAAACCGTAC
TTCTACCATTCCGTGGCAGTGTTCACGGCACTATCCAAGACATCCTTGGCGGTGTTCGCTCAACATGTACTTACGTAGGT
GCAGCTAAGCTTAAAGAGCTAACCAAACGTACTACGTTCATCCGCGTACAAGAGCAAGAAAACAACGTATTCGGTAAAGA
GTAA

Upstream 100 bases:

>100_bases
CTCCGGTTTTTTGTGTCCGAAGAACAGTGAACTCGTCTGCCAACGATGCCACTACGCACTCTGAGATGACACATATACTT
ATGAATCAAGGAATTACACA

Downstream 100 bases:

>100_bases
TGTTTAAAACGCTTGTTTAAATGTAAAAACAACTAAACGTTGAATTTACGAAACCATACGTTGAAATAAAAACAACCATA
CCTTGAAATAGCTTGTTTAG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGVPVIAANMDSVGSFAMAKALAEHGVMTAVHKHYT
VEDWAEFANTADKATLNNVMVSTGTSEADFQKTKDIMAISDEFIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVV
TGDMCEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKQFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPFRGSVHGTIQDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE

Sequences:

>Translated_347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGVPVIAANMDSVGSFAMAKALAEHGVMTAVHKHYT
VEDWAEFANTADKATLNNVMVSTGTSEADFQKTKDIMAISDEFIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVV
TGDMCEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKQFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPFRGSVHGTIQDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE
>Mature_347_residues
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGVPVIAANMDSVGSFAMAKALAEHGVMTAVHKHYT
VEDWAEFANTADKATLNNVMVSTGTSEADFQKTKDIMAISDEFIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVV
TGDMCEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVAKAFGGGADFVM
LGGMLAGHEESGGEVIEQDGKQFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPFRGSVHGTIQDILGGVRSTCTYVG
AAKLKELTKRTTFIRVQEQENNVFGKE

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=344, Percent_Identity=65.6976744186046, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI50541954, Length=344, Percent_Identity=65.6976744186046, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI50541952, Length=344, Percent_Identity=65.6976744186046, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI50541948, Length=344, Percent_Identity=65.6976744186046, Blast_Score=477, Evalue=1e-135,
Organism=Homo sapiens, GI156104880, Length=343, Percent_Identity=63.8483965014577, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI66933016, Length=209, Percent_Identity=32.0574162679426, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI217035146, Length=209, Percent_Identity=33.0143540669856, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI217035150, Length=209, Percent_Identity=33.0143540669856, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI217035152, Length=209, Percent_Identity=33.0143540669856, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI217035148, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI34328930, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI34328928, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI156616279, Length=209, Percent_Identity=33.0143540669856, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=73.546511627907, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1788855, Length=218, Percent_Identity=38.9908256880734, Blast_Score=132, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=61.8075801749271, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71994385, Length=214, Percent_Identity=31.3084112149533, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994389, Length=165, Percent_Identity=34.5454545454545, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=32.3404255319149, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=32.3404255319149, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=32.4894514767932, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641071, Length=235, Percent_Identity=30.6382978723404, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24641073, Length=235, Percent_Identity=30.6382978723404, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571163, Length=249, Percent_Identity=28.9156626506024, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37073; Mature: 37073

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGVPVIAANMDSVGSF
CCCHHHHHCCHHHHHCCCCHHHHHCCCCEEEEEEEEEEECCCCCCCCEEEEECCCCHHHH
AMAKALAEHGVMTAVHKHYTVEDWAEFANTADKATLNNVMVSTGTSEADFQKTKDIMAIS
HHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCHHHHCCEEEECCCCHHHHHHHHHHHEEC
DEFIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVVTGDMCEELILAGADIVKVGI
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHH
LGGMLAGHEESGGEVIEQDGKQFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPFRGS
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCCEEEEECCCC
VHGTIQDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
>Mature Secondary Structure
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTRDFTFKHSGRQWSGVPVIAANMDSVGSF
CCCHHHHHCCHHHHHCCCCHHHHHCCCCEEEEEEEEEEECCCCCCCCEEEEECCCCHHHH
AMAKALAEHGVMTAVHKHYTVEDWAEFANTADKATLNNVMVSTGTSEADFQKTKDIMAIS
HHHHHHHHCCHHHHHHHCCCHHHHHHHHCCCCHHHHCCEEEECCCCHHHHHHHHHHHEEC
DEFIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVVTGDMCEELILAGADIVKVGI
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCEEEHHHHHHHHHCCCCEEEECC
GPGSVCTTRVKTGVGYPQLSAIIECGDAAHGLGGMIIGDGGCSCAGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCHHH
LGGMLAGHEESGGEVIEQDGKQFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPFRGS
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCCEEEEECCCC
VHGTIQDILGGVRSTCTYVGAAKLKELTKRTTFIRVQEQENNVFGKE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]