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The map label for this gene is atpB2

Identifier: 156977324

GI number: 156977324

Start: 1271381

End: 1272148

Strand: Reverse

Name: atpB2

Synonym: VIBHAR_06110

Alternate gene names: 156977324

Gene position: 1272148-1271381 (Counterclockwise)

Preceding gene: 156977325

Following gene: 156977323

Centisome position: 57.72

GC content: 40.49

Gene sequence:

>768_bases
ATGGAGACTGTCCAGTCCGCTCATGAATATATTGAGCACCACCTGACCTTTCTCACCGCCGGCGACGGTTGGTTTGGAAT
TAACCTTGATTCCATGATCATGGTCTGGCTGACGGGGCTCGTTTTCATCCTTTCATTCCGTTATGCGGTGACGAAAGGAA
CGAAAGGAGTACCAGGACGATTCCAGTGTTTGATCGAGATAATATTTGAGTTCGTCGATGACATCGTAAAAGAAATATTT
CAAGCCAAGGACAAGTTAATTGGTCCCTTAGCACTGACAATATTTGTTTGGGTGTTATTAATGAATGCCGTGGATTTGTT
ACCGATTGATTTAATTCCTGCACTTACTAGTGCTGTAGGCGTTGAACACTTTCGTGACTTACCATCCGCTGACATCAATA
TTACGATGTCTATGGCATTAGGCGTGTTTATTTTGGTTTTAGGTTATACGTTTAAAAACAAGGGCGTGAAAGGTTTTATT
AAAGAGTTAACTACTCAACCGTTTTCACATCCGTTGTTATATCCAGTGAACTTAGTTCTTGAATTGGTAACGTTAATTTC
TAAACCAATATCTTTGGGTCTTCGATTGTTTGGCAATATGTATGCAGGTGAAATGATCTTCATTCTAATTGCATTAATGC
CGTGGTGGATGCAATGGGCACTAAGTGTTCCTTGGGCACTGTTCCACATTCTTATTGTTGTTCTTCAAGCATTTATTTTT
ATGGTGCTGACCGTGGTTTATCTCGGTATGGCTGTTGAAGAGCATTAA

Upstream 100 bases:

>100_bases
GGCTCTTCGCAACATCGTGGTCCTGATAGGCTTTTGTGTGACGATGTTTGGTCACTTCTTAACGCCGCTGTTCAGAGACC
GCTTCGAAAGGAAGGCATAA

Downstream 100 bases:

>100_bases
TTTCAAAAATCTTGTTTCTTAATTAAAAAATTCAATTCTAGGAGTTGTTATGGATATCGTTAGCGCAGTTCTTTACGTGG
CGGGTGCACTACTGATCGGT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a 2; F-ATPase subunit 6 2

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
METVQSAHEYIEHHLTFLTAGDGWFGINLDSMIMVWLTGLVFILSFRYAVTKGTKGVPGRFQCLIEIIFEFVDDIVKEIF
QAKDKLIGPLALTIFVWVLLMNAVDLLPIDLIPALTSAVGVEHFRDLPSADINITMSMALGVFILVLGYTFKNKGVKGFI
KELTTQPFSHPLLYPVNLVLELVTLISKPISLGLRLFGNMYAGEMIFILIALMPWWMQWALSVPWALFHILIVVLQAFIF
MVLTVVYLGMAVEEH

Sequences:

>Translated_255_residues
METVQSAHEYIEHHLTFLTAGDGWFGINLDSMIMVWLTGLVFILSFRYAVTKGTKGVPGRFQCLIEIIFEFVDDIVKEIF
QAKDKLIGPLALTIFVWVLLMNAVDLLPIDLIPALTSAVGVEHFRDLPSADINITMSMALGVFILVLGYTFKNKGVKGFI
KELTTQPFSHPLLYPVNLVLELVTLISKPISLGLRLFGNMYAGEMIFILIALMPWWMQWALSVPWALFHILIVVLQAFIF
MVLTVVYLGMAVEEH
>Mature_255_residues
METVQSAHEYIEHHLTFLTAGDGWFGINLDSMIMVWLTGLVFILSFRYAVTKGTKGVPGRFQCLIEIIFEFVDDIVKEIF
QAKDKLIGPLALTIFVWVLLMNAVDLLPIDLIPALTSAVGVEHFRDLPSADINITMSMALGVFILVLGYTFKNKGVKGFI
KELTTQPFSHPLLYPVNLVLELVTLISKPISLGLRLFGNMYAGEMIFILIALMPWWMQWALSVPWALFHILIVVLQAFIF
MVLTVVYLGMAVEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=265, Percent_Identity=58.1132075471698, Blast_Score=281, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP62_VIBHB (A7N2U2)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001448230.1
- ProteinModelPortal:   A7N2U2
- SMR:   A7N2U2
- STRING:   A7N2U2
- GeneID:   5556654
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_06110
- NMPDR:   fig|338187.4.peg.3598
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   APINVVE
- ProtClustDB:   PRK05815
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 28749; Mature: 28749

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a7c92c8)-; HASH(0x19275cdc)-; HASH(0x1a368e10)-; HASH(0x196ba190)-; HASH(0x1abce7b8)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCH
>Mature Secondary Structure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HHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA