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The map label for this gene is fruA [H]

Identifier: 156977174

GI number: 156977174

Start: 1147155

End: 1148900

Strand: Direct

Name: fruA [H]

Synonym: VIBHAR_05960

Alternate gene names: 156977174

Gene position: 1147155-1148900 (Clockwise)

Preceding gene: 156977173

Following gene: 156977180

Centisome position: 52.05

GC content: 49.2

Gene sequence:

>1746_bases
ATGAATATTGCCATTATTACAGCTTGTCCAAGTGGTGTTGCGAACAGCATCATTGCGGCAGGCCTACTAGAACAAGCAGC
AGCTAAGTTGGGTTGGAACGCTAAGATTGAATGCCAATCAAACGTGGTTGAACCAACACTGCTAACAGACGCTGACATTG
AACAAGCAGAAGCGATCGTAATTGCGGCTAACACTCCAGTTGATACTTCTCGTTTCGTAGGTAAAAAAGTCTACCAAGCA
GATATCAGCACCGTTGCAAAAGACGCAATGGCTTTCCTACAGACTGCGGTTGAAAACTCAGCAACACTAGAGCAAGCAAC
CACAGATACGGCACAAGTAGCAGCACCAGCAGAAAGCGCATCTGCAACGAAGAAGATCGTTGCGGTCACAGCATGTCCAA
CTGGCGTAGCACACACCTTCATGGCAGCAGAGGCGCTAGAGGAAGAAGGCAAACGTCGTGGTCACCAAATCAAAGTGGAA
ACGCGTGGCTCAGTAGGTGCGAAAAACCAACTGACTGATCAAGAAATCGCAGACGCAGATTTAGTGATCATCGCAGCGGA
TATTGAAGTACCTCTTGACCGCTTCAACGGCAAAAAAATGTACCGTACTAAAACAGGCCCAGCGCTGAAGAAAACAGCGG
AAGAAATGGACAAAGCGTTTGAACAAGCAAGCGTATACCAACACTCTGGTTCTTCTAGCGCATCATCAACGACAGAAGAG
AAGAAAGGCGCGTACAAGCACCTAATGACTGGTGTATCTCACATGCTTCCAGTTGTGGTTGCAGGTGGTTTGATCATCGC
CCTATCCTTCGTATTTGGTATCGAAGCATTTAAAGAAGAAGGCACGCTAGCAGCAGCACTGATGAACATCGGTGGTGGCT
CAGCATTCGCTCTGATGATTCCAGTGCTTGCTGGCTACATCGCCTTCTCTATTGCTGACCGTCCAGGTCTGGCTCCGGGT
CTTGTGGGCGGTATGCTTGCTAGCTCAACCGGCGCAGGTTTCCTTGGTGGTATCGCAGCAGGTTTCATTGCCGGTTACGC
AGCGAAGTTCCTAGCCGACAAAGTAAAACTTCCACAATCAATGGAAGCGCTTAAACCGATCCTTATCATTCCTTTCGTGG
CGACACTGTTCACGGGTCTGGTGATGATTTACATCGTAGGTGGTCCGGTTTCAGGCATCATGAGCGGCCTAACTGACTTC
CTAAACAACATGGGTTCTGACAGCGCAGTTCTACTGGGTATTATCCTTGGCGCAATGATGTGTTTCGACCTAGGTGGTCC
AGTAAACAAAGCCGCTTACGCATTCGGTGTGGGTCTATTGGCTTCGCAAACTTACGCGCCAATGGCGGCAATCATGGCGG
CAGGTATGGTTCCTGCGCTTGGTATGGGTCTTGCGACATTCCTTGCTAAGAACAAGTTTGAGCAAAGCGAGCGTGAAGCG
GGTAAAGCATCATTCGTTCTTGGTCTGTGCTTTATCTCTGAAGGTGCAATCCCATTTGCAGCGAAAGATCCAATGCGTGT
TATCCCATCATGCATGGCAGGTGGCGCACTAACAGGTGCACTATCTATGCTGTTCGGTGCAAAACTGATGGCACCACACG
GTGGCTTGTTCGTGCTGCTTATCCCTAACGCAATCTCACCAGTCCTGATGTACTTGGTAGCAATTGCAGCAGGTACAGCG
GTAACGGGCTTCACTTACGCGTTCCTAAAGAACAAATCAGAAGCGGAACAACAAGCTGCAGCTTAA

Upstream 100 bases:

>100_bases
AGTCAGGAAGAACTGGAGAACATTAAGCTCCAAACCGAAGTTACCGAGCTTTACCCTAATACGAACTTAGACAAAAACTA
AGGAACAGAAGGTTATCAGT

Downstream 100 bases:

>100_bases
TCGCAAACAGCGATTAAATAACAGTTAACAATGCCTCCCTCGATTTGGCATTCGACACCTCCCTCAAGGCTCGGCTTTGG
GAGGTGTTTTTTATTATGTC

Product: PTS system fructose-specific IIBC component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MNIAIITACPSGVANSIIAAGLLEQAAAKLGWNAKIECQSNVVEPTLLTDADIEQAEAIVIAANTPVDTSRFVGKKVYQA
DISTVAKDAMAFLQTAVENSATLEQATTDTAQVAAPAESASATKKIVAVTACPTGVAHTFMAAEALEEEGKRRGHQIKVE
TRGSVGAKNQLTDQEIADADLVIIAADIEVPLDRFNGKKMYRTKTGPALKKTAEEMDKAFEQASVYQHSGSSSASSTTEE
KKGAYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMNIGGGSAFALMIPVLAGYIAFSIADRPGLAPG
LVGGMLASSTGAGFLGGIAAGFIAGYAAKFLADKVKLPQSMEALKPILIIPFVATLFTGLVMIYIVGGPVSGIMSGLTDF
LNNMGSDSAVLLGIILGAMMCFDLGGPVNKAAYAFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFLAKNKFEQSEREA
GKASFVLGLCFISEGAIPFAAKDPMRVIPSCMAGGALTGALSMLFGAKLMAPHGGLFVLLIPNAISPVLMYLVAIAAGTA
VTGFTYAFLKNKSEAEQQAAA

Sequences:

>Translated_581_residues
MNIAIITACPSGVANSIIAAGLLEQAAAKLGWNAKIECQSNVVEPTLLTDADIEQAEAIVIAANTPVDTSRFVGKKVYQA
DISTVAKDAMAFLQTAVENSATLEQATTDTAQVAAPAESASATKKIVAVTACPTGVAHTFMAAEALEEEGKRRGHQIKVE
TRGSVGAKNQLTDQEIADADLVIIAADIEVPLDRFNGKKMYRTKTGPALKKTAEEMDKAFEQASVYQHSGSSSASSTTEE
KKGAYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMNIGGGSAFALMIPVLAGYIAFSIADRPGLAPG
LVGGMLASSTGAGFLGGIAAGFIAGYAAKFLADKVKLPQSMEALKPILIIPFVATLFTGLVMIYIVGGPVSGIMSGLTDF
LNNMGSDSAVLLGIILGAMMCFDLGGPVNKAAYAFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFLAKNKFEQSEREA
GKASFVLGLCFISEGAIPFAAKDPMRVIPSCMAGGALTGALSMLFGAKLMAPHGGLFVLLIPNAISPVLMYLVAIAAGTA
VTGFTYAFLKNKSEAEQQAAA
>Mature_581_residues
MNIAIITACPSGVANSIIAAGLLEQAAAKLGWNAKIECQSNVVEPTLLTDADIEQAEAIVIAANTPVDTSRFVGKKVYQA
DISTVAKDAMAFLQTAVENSATLEQATTDTAQVAAPAESASATKKIVAVTACPTGVAHTFMAAEALEEEGKRRGHQIKVE
TRGSVGAKNQLTDQEIADADLVIIAADIEVPLDRFNGKKMYRTKTGPALKKTAEEMDKAFEQASVYQHSGSSSASSTTEE
KKGAYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMNIGGGSAFALMIPVLAGYIAFSIADRPGLAPG
LVGGMLASSTGAGFLGGIAAGFIAGYAAKFLADKVKLPQSMEALKPILIIPFVATLFTGLVMIYIVGGPVSGIMSGLTDF
LNNMGSDSAVLLGIILGAMMCFDLGGPVNKAAYAFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFLAKNKFEQSEREA
GKASFVLGLCFISEGAIPFAAKDPMRVIPSCMAGGALTGALSMLFGAKLMAPHGGLFVLLIPNAISPVLMYLVAIAAGTA
VTGFTYAFLKNKSEAEQQAAA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=574, Percent_Identity=63.0662020905923, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1786951, Length=511, Percent_Identity=36.2035225048924, Blast_Score=281, Evalue=1e-76,
Organism=Escherichia coli, GI87082348, Length=478, Percent_Identity=35.3556485355649, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1790386, Length=305, Percent_Identity=43.9344262295082, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1788729, Length=397, Percent_Identity=27.455919395466, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790387, Length=88, Percent_Identity=52.2727272727273, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788730, Length=93, Percent_Identity=43.010752688172, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=46.1538461538462, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 59759; Mature: 59759

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAIITACPSGVANSIIAAGLLEQAAAKLGWNAKIECQSNVVEPTLLTDADIEQAEAIV
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEECCCCCCCCCEEE
IAANTPVDTSRFVGKKVYQADISTVAKDAMAFLQTAVENSATLEQATTDTAQVAAPAESA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHH
SATKKIVAVTACPTGVAHTFMAAEALEEEGKRRGHQIKVETRGSVGAKNQLTDQEIADAD
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCC
LVIIAADIEVPLDRFNGKKMYRTKTGPALKKTAEEMDKAFEQASVYQHSGSSSASSTTEE
EEEEEECCCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
KKGAYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMNIGGGSAFALMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
PVLAGYIAFSIADRPGLAPGLVGGMLASSTGAGFLGGIAAGFIAGYAAKFLADKVKLPQS
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MEALKPILIIPFVATLFTGLVMIYIVGGPVSGIMSGLTDFLNNMGSDSAVLLGIILGAMM
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CFDLGGPVNKAAYAFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFLAKNKFEQSEREA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKASFVLGLCFISEGAIPFAAKDPMRVIPSCMAGGALTGALSMLFGAKLMAPHGGLFVLL
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEE
IPNAISPVLMYLVAIAAGTAVTGFTYAFLKNKSEAEQQAAA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MNIAIITACPSGVANSIIAAGLLEQAAAKLGWNAKIECQSNVVEPTLLTDADIEQAEAIV
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEECCCCCCCCCEEE
IAANTPVDTSRFVGKKVYQADISTVAKDAMAFLQTAVENSATLEQATTDTAQVAAPAESA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHH
SATKKIVAVTACPTGVAHTFMAAEALEEEGKRRGHQIKVETRGSVGAKNQLTDQEIADAD
HHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCC
LVIIAADIEVPLDRFNGKKMYRTKTGPALKKTAEEMDKAFEQASVYQHSGSSSASSTTEE
EEEEEECCCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
KKGAYKHLMTGVSHMLPVVVAGGLIIALSFVFGIEAFKEEGTLAAALMNIGGGSAFALMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
PVLAGYIAFSIADRPGLAPGLVGGMLASSTGAGFLGGIAAGFIAGYAAKFLADKVKLPQS
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MEALKPILIIPFVATLFTGLVMIYIVGGPVSGIMSGLTDFLNNMGSDSAVLLGIILGAMM
HHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CFDLGGPVNKAAYAFGVGLLASQTYAPMAAIMAAGMVPALGMGLATFLAKNKFEQSEREA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKASFVLGLCFISEGAIPFAAKDPMRVIPSCMAGGALTGALSMLFGAKLMAPHGGLFVLL
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEE
IPNAISPVLMYLVAIAAGTAVTGFTYAFLKNKSEAEQQAAA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]