Click here to switch to the map view.

The map label for this gene is hmgA [H]

Identifier: 156976919

GI number: 156976919

Start: 907473

End: 908735

Strand: Reverse

Name: hmgA [H]

Synonym: VIBHAR_05704

Alternate gene names: 156976919

Gene position: 908735-907473 (Counterclockwise)

Preceding gene: 156976922

Following gene: 156976918

Centisome position: 41.23

GC content: 47.9

Gene sequence:

>1263_bases
ATGCCGAAATTAAATTTAGACAGCGCAAGGAATAGCTCTGCACTCTCTGAGAATGGAACCTGCGAAAAAGTACAATCGGC
ATTAGAACCGAAATACCACAAGCCAGAAAAGAAACTCTGCCTTAGCGCAGGTCTGACGGAAAAGCACATTGCGCGCCGTT
GGAAGTTGCTAGAATCCATGACGGACAAAGATCTTATTCTGGATCCTTTTACTCAATCGCATTACGACCAATACGCCAAC
AACATCGAACACTTTATTGGTACCGTTAATGTTCCTGTTGGTGTTGCCGGCCCTCTGCGTATTAACGGCCTTTACGCGAA
CGACGACTACTTAGTCCCTCTCGCAACAACAGAAGCTGCATTGGTCGCTTCTTACAACCGCGGTGCAAACTTAATTACTG
CCGCCGGTGGTGCAAGTACCCTTTTGATCAGTGAAGGTGTTAGCCGTACACCTGTGTTTGGCTTCCAATCTCTTGCAGAA
GCCGCGCAGTTCGTAAGTTGGGTGGTAACTCAATACGATATCTTCCGTAAAGAAGCAGAATCCACCACCACGCACGGCAA
GCTAAAAGACATCAACGTGAATATTGAAGGCAATCATGTTTACTTGGTGTTTGAATACGTGACGGGCGATGCGTCCGGTC
AGAACATGGTCACCATCGCGACACACAAGGTATTCCACTACATTCTCGAACACAGCCCTATCGCTCCGGTTGATGCTTAC
CTTGACGGTAACTTGTCTGGTGATAAGAAGGCCAACGCTCACACCTTGCGTTCCGTTCGCGGTAAAAAAGTATCCGCTGA
AGTGACGATTCCTGCGGCTTTGGTTAAGAAATACCTGCACACCACGCCAGAAGCCATGGTCAAATTTGGCAAGATGAATA
CGGTCGGTGGCTTACTAAGTGGCACCATAGGTATTAACGCACACTACGCCAATGCCCTCACCGCTTTGTACATCGCATGC
GGCCAAGATGCGGCTTGCGTAGCAGAATCTGCGGTTGGTATTACTCGAATGGATGTGGATTCTCAAGGAAACTTGTATAC
CTCTGTCACCCTGCCAAATATCATGGTTGGTACTGTAGGCGGTGGTACTGGCTTGCCAACTCAAAAAGCGTGTTTGGATA
TCCTTGGTTTGCACGGAAATGGTAAAGCAAAGGCGTTAGCAGAAGTCGCTGCTGGTCTGTGTTTGGCTGGTGAGCTTTCA
ATTGTTGGTGCATTCTGTGCCGATCATTTCTCTCGTGCACATCATAAACTAGCAAGAAAGTAA

Upstream 100 bases:

>100_bases
TTGAAGCTGAGCAACCTTTTGTTGCAAAACGTATACGCGGGATTGTAATCACGTTTTGTATCACTACAATTCCAAACCAA
ATGAATAAAGAAACGTTTGT

Downstream 100 bases:

>100_bases
CAGCTCGAAATCTAGGGAAGCCACTCTTTGTCATTCATAGAGTGGTTTCTTTTACTACATACCGCCAATGGCACCTCAAT
CAAACACTGTACAAACCCCC

Product: 3-hydroxy-3-methylglutaryl CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPKLNLDSARNSSALSENGTCEKVQSALEPKYHKPEKKLCLSAGLTEKHIARRWKLLESMTDKDLILDPFTQSHYDQYAN
NIEHFIGTVNVPVGVAGPLRINGLYANDDYLVPLATTEAALVASYNRGANLITAAGGASTLLISEGVSRTPVFGFQSLAE
AAQFVSWVVTQYDIFRKEAESTTTHGKLKDINVNIEGNHVYLVFEYVTGDASGQNMVTIATHKVFHYILEHSPIAPVDAY
LDGNLSGDKKANAHTLRSVRGKKVSAEVTIPAALVKKYLHTTPEAMVKFGKMNTVGGLLSGTIGINAHYANALTALYIAC
GQDAACVAESAVGITRMDVDSQGNLYTSVTLPNIMVGTVGGGTGLPTQKACLDILGLHGNGKAKALAEVAAGLCLAGELS
IVGAFCADHFSRAHHKLARK

Sequences:

>Translated_420_residues
MPKLNLDSARNSSALSENGTCEKVQSALEPKYHKPEKKLCLSAGLTEKHIARRWKLLESMTDKDLILDPFTQSHYDQYAN
NIEHFIGTVNVPVGVAGPLRINGLYANDDYLVPLATTEAALVASYNRGANLITAAGGASTLLISEGVSRTPVFGFQSLAE
AAQFVSWVVTQYDIFRKEAESTTTHGKLKDINVNIEGNHVYLVFEYVTGDASGQNMVTIATHKVFHYILEHSPIAPVDAY
LDGNLSGDKKANAHTLRSVRGKKVSAEVTIPAALVKKYLHTTPEAMVKFGKMNTVGGLLSGTIGINAHYANALTALYIAC
GQDAACVAESAVGITRMDVDSQGNLYTSVTLPNIMVGTVGGGTGLPTQKACLDILGLHGNGKAKALAEVAAGLCLAGELS
IVGAFCADHFSRAHHKLARK
>Mature_419_residues
PKLNLDSARNSSALSENGTCEKVQSALEPKYHKPEKKLCLSAGLTEKHIARRWKLLESMTDKDLILDPFTQSHYDQYANN
IEHFIGTVNVPVGVAGPLRINGLYANDDYLVPLATTEAALVASYNRGANLITAAGGASTLLISEGVSRTPVFGFQSLAEA
AQFVSWVVTQYDIFRKEAESTTTHGKLKDINVNIEGNHVYLVFEYVTGDASGQNMVTIATHKVFHYILEHSPIAPVDAYL
DGNLSGDKKANAHTLRSVRGKKVSAEVTIPAALVKKYLHTTPEAMVKFGKMNTVGGLLSGTIGINAHYANALTALYIACG
QDAACVAESAVGITRMDVDSQGNLYTSVTLPNIMVGTVGGGTGLPTQKACLDILGLHGNGKAKALAEVAAGLCLAGELSI
VGAFCADHFSRAHHKLARK

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=397, Percent_Identity=37.27959697733, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI196049380, Length=300, Percent_Identity=38, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144592, Length=347, Percent_Identity=43.8040345821326, Blast_Score=254, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6323483, Length=391, Percent_Identity=36.5728900255754, Blast_Score=209, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6323565, Length=401, Percent_Identity=36.6583541147132, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI281362379, Length=364, Percent_Identity=37.0879120879121, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI45553469, Length=364, Percent_Identity=37.0879120879121, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI24649399, Length=364, Percent_Identity=37.0879120879121, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44780; Mature: 44648

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLNLDSARNSSALSENGTCEKVQSALEPKYHKPEKKLCLSAGLTEKHIARRWKLLESM
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
TDKDLILDPFTQSHYDQYANNIEHFIGTVNVPVGVAGPLRINGLYANDDYLVPLATTEAA
CCCCEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEEECCCEEEEEECCCEE
LVASYNRGANLITAAGGASTLLISEGVSRTPVFGFQSLAEAAQFVSWVVTQYDIFRKEAE
EEEECCCCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
STTTHGKLKDINVNIEGNHVYLVFEYVTGDASGQNMVTIATHKVFHYILEHSPIAPVDAY
CCCCCCEEEEEEEEEECCEEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHE
LDGNLSGDKKANAHTLRSVRGKKVSAEVTIPAALVKKYLHTTPEAMVKFGKMNTVGGLLS
ECCCCCCCCCCCHHHHHHHCCCEEEEEEECHHHHHHHHHHCCHHHHHHHCCCCHHHHHHC
GTIGINAHYANALTALYIACGQDAACVAESAVGITRMDVDSQGNLYTSVTLPNIMVGTVG
CEEECCCHHHHHHHHHHEECCCCHHHHHHHHCCEEEEEECCCCCEEEEEECCCEEEEECC
GGTGLPTQKACLDILGLHGNGKAKALAEVAAGLCLAGELSIVGAFCADHFSRAHHKLARK
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKLNLDSARNSSALSENGTCEKVQSALEPKYHKPEKKLCLSAGLTEKHIARRWKLLESM
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHC
TDKDLILDPFTQSHYDQYANNIEHFIGTVNVPVGVAGPLRINGLYANDDYLVPLATTEAA
CCCCEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEEECCCEEEEEECCCEE
LVASYNRGANLITAAGGASTLLISEGVSRTPVFGFQSLAEAAQFVSWVVTQYDIFRKEAE
EEEECCCCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
STTTHGKLKDINVNIEGNHVYLVFEYVTGDASGQNMVTIATHKVFHYILEHSPIAPVDAY
CCCCCCEEEEEEEEEECCEEEEEEEEEECCCCCCEEEEEHHHHHHHHHHHCCCCCCCHHE
LDGNLSGDKKANAHTLRSVRGKKVSAEVTIPAALVKKYLHTTPEAMVKFGKMNTVGGLLS
ECCCCCCCCCCCHHHHHHHCCCEEEEEEECHHHHHHHHHHCCHHHHHHHCCCCHHHHHHC
GTIGINAHYANALTALYIACGQDAACVAESAVGITRMDVDSQGNLYTSVTLPNIMVGTVG
CEEECCCHHHHHHHHHHEECCCCHHHHHHHHCCEEEEEECCCCCEEEEEECCCEEEEECC
GGTGLPTQKACLDILGLHGNGKAKALAEVAAGLCLAGELSIVGAFCADHFSRAHHKLARK
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]