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The map label for this gene is cyoE1

Identifier: 156976720

GI number: 156976720

Start: 706361

End: 707233

Strand: Direct

Name: cyoE1

Synonym: VIBHAR_05495

Alternate gene names: 156976720

Gene position: 706361-707233 (Clockwise)

Preceding gene: 156976719

Following gene: 156976721

Centisome position: 32.05

GC content: 46.85

Gene sequence:

>873_bases
ATGCTGAAAAGATATTTGTCTATTACCAAACCGGGCATCATTTTCGGCAACCTGATTTCTGTTGCGGCGGGGTTCTTCCT
CGCCGCAAAATCAGAACCAGCGAGCTTTCTGTTGTTATTGACAACGTTAGTTGGCGTGGGGCTTGTAATTGCATCAGGAT
GCGTGGTGAATAACATCTTTGACCGCGATATCGATCAAAAGATGAAGCGCACGCAAAACCGCGAATTGGTGATGGGTAAC
ATCAATACCGACGCGGCTTTTGTTTATGCTTTAGTATTGTTGCTTAACGGAACGGCGCTGCTATTCCAAGTGGTGAATCC
GCTTTCGGCCGTGGTTGTACTCTTGGGTTACGTGTTTTATGTCTTCTTTTACACTATGTGGTACAAGCGAAATTCAGTTT
ACGGCACCTTAGTTGGCAGTATTTCCGGCGCAGTTCCTCCTTTGGTGGGTTACCTAGCCGTGACCAACTACATTAGCTTG
GAAGCTACATTGCTGTTCGTCATGTTTTGTCTGTGGCAAATGCCGCACTCTTACGCGATTGCTATGTTCCGCATGCAAGA
TTACCGTGATGCAGGCATTCCAGTGCTTCCTGTTAAAGAGGGGATTGCCAAAGCGCATCAGCATATGAAAGCGTACGTGG
TTGCTTTTGGCGTGGTTGCTATCGGGCTGTTTATGCTAGGTGAAGCAGGTTACGAGTACTTAGCCGTTTCGGCGGCGGTG
TGTTTTATGTGGACACGTGTGACGTTCCAAAAAGTGGATTACAACAACTACATCCAGTGGTCTAAATCGGTGTTTAAGAT
GTCGTTATTGGTTGTCATGGGCATCAGCGGCGTACTTGGTCTGGAGTTGATTCCACTGCCGTTTATTCATTAA

Upstream 100 bases:

>100_bases
TTTCACTGATGTTTACCGCCATTGTTGTTTTGATTCTTATCGCAGGTTCGATTTGGATCATCTACAACATGAACGTCAAC
ATGAAGTTGTAGGCTAGGGT

Downstream 100 bases:

>100_bases
AGGAAAGTAGGTCTGAGTTAACGATTGATGCCATCAGTAGTGGTGATGAGAACAAACCCAATGAATGCGAAATCGGTGAC
CTATCTCACCAAACCTTAAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MLKRYLSITKPGIIFGNLISVAAGFFLAAKSEPASFLLLLTTLVGVGLVIASGCVVNNIFDRDIDQKMKRTQNRELVMGN
INTDAAFVYALVLLLNGTALLFQVVNPLSAVVVLLGYVFYVFFYTMWYKRNSVYGTLVGSISGAVPPLVGYLAVTNYISL
EATLLFVMFCLWQMPHSYAIAMFRMQDYRDAGIPVLPVKEGIAKAHQHMKAYVVAFGVVAIGLFMLGEAGYEYLAVSAAV
CFMWTRVTFQKVDYNNYIQWSKSVFKMSLLVVMGISGVLGLELIPLPFIH

Sequences:

>Translated_290_residues
MLKRYLSITKPGIIFGNLISVAAGFFLAAKSEPASFLLLLTTLVGVGLVIASGCVVNNIFDRDIDQKMKRTQNRELVMGN
INTDAAFVYALVLLLNGTALLFQVVNPLSAVVVLLGYVFYVFFYTMWYKRNSVYGTLVGSISGAVPPLVGYLAVTNYISL
EATLLFVMFCLWQMPHSYAIAMFRMQDYRDAGIPVLPVKEGIAKAHQHMKAYVVAFGVVAIGLFMLGEAGYEYLAVSAAV
CFMWTRVTFQKVDYNNYIQWSKSVFKMSLLVVMGISGVLGLELIPLPFIH
>Mature_290_residues
MLKRYLSITKPGIIFGNLISVAAGFFLAAKSEPASFLLLLTTLVGVGLVIASGCVVNNIFDRDIDQKMKRTQNRELVMGN
INTDAAFVYALVLLLNGTALLFQVVNPLSAVVVLLGYVFYVFFYTMWYKRNSVYGTLVGSISGAVPPLVGYLAVTNYISL
EATLLFVMFCLWQMPHSYAIAMFRMQDYRDAGIPVLPVKEGIAKAHQHMKAYVVAFGVVAIGLFMLGEAGYEYLAVSAAV
CFMWTRVTFQKVDYNNYIQWSKSVFKMSLLVVMGISGVLGLELIPLPFIH

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=176, Percent_Identity=36.3636363636364, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786631, Length=284, Percent_Identity=47.887323943662, Blast_Score=263, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI71998235, Length=166, Percent_Identity=33.7349397590361, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325085, Length=188, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19921064, Length=192, Percent_Identity=31.25, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE1_VIBHB (A7N2M2)

Other databases:

- EMBL:   CP000790
- RefSeq:   YP_001447626.1
- STRING:   A7N2M2
- GeneID:   5558300
- GenomeReviews:   CP000790_GR
- KEGG:   vha:VIBHAR_05495
- NMPDR:   fig|338187.4.peg.3228
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   VGYCAVT
- ProtClustDB:   CLSK913298
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32099; Mature: 32099

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x195d0164)-; HASH(0x1978a4b4)-; HASH(0x19761a60)-; HASH(0x1712bfa8)-; HASH(0x1947aeec)-; HASH(0x1973a6c0)-; HASH(0x198257e0)-; HASH(0x193d6994)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure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HHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA