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The map label for this gene is ubiB [H]

Identifier: 156976550

GI number: 156976550

Start: 556984

End: 558306

Strand: Reverse

Name: ubiB [H]

Synonym: VIBHAR_05324

Alternate gene names: 156976550

Gene position: 558306-556984 (Counterclockwise)

Preceding gene: 156976551

Following gene: 156976549

Centisome position: 25.33

GC content: 48.15

Gene sequence:

>1323_bases
ATGTCGGCAAAGGAAAGAAGCCTACCCACCCATCGCATCTCAAGATTCAGCAAGTTCGCTTCCCTTGCAACCCGAGTCGC
AGGCAACGTGATTGCTGAAGGCACTAAACAAATCGCTAAAGGCAATAAACCCAAAGCGAAAGACCTGTTACTAACGCCGC
AAAACATTGCGCGTTTAACAGACCAACTGGCCCACTTGCGGGGTGCAGCGATGAAACTTGGTCAAATGCTCTCTATGGAT
GCTGGCGATGTTTTGGAACCAGACCTCGCTGATATTCTCTCGCGACTTCGCTCAAACGCAGATCCTATGCCAGCAAAACA
ACTCAACGCAGTAATGGAAAACGCGCTAGGAACGAATTGGAAAACTGAGTTCCTCTCCTTTAACTTCAAGCCAATAGCCA
GCGCTTCCATTGGTCAAGTTCACCAGGCCTACAGTGATGCAGGTGATAACCTCGCGGTGAAAGTGCAGTATCCGGGAGTA
AGGAAAAGTATCGACAGTGACGTCGATAACGTGGGGACTCTGCTCAAAGTCGTTGGCTTGATTCCCGAATCTGTTGATTA
CAAAGGACTATTGGAAGAAGCTAAAAAGCAACTGCATGATGAAGCTGATTACGCACGAGAAGCGCACTTTGCCATTCGTT
ATCATGACGCTTTGAAGGATCACCCTCATTTTGTCGTGCCGAAAATCCACACCGGAAGCTCTTCCGACGCCGTGCTCGCA
ATGGAATTTATTGACGGTAGTCCGATTGAACAAATCGAGCATTATGACCAAAGCACACGCGACTTTGTAATGCACAGTTT
ACTCGAATTGCTGTTCCGAGAGCTGTTCGAATTTAAAATGGTCCAAACCGACCCCAACTTTGCCAACTACTTGTATATCG
AGAACACCCGTCAAATCGGCTTGTTAGATTTCGGCGCGACTCGCGAATACAGCGAACAATTTAGCACTGGTTATCGCCAA
GCTTTTGCATCGGTTGTCAACGACGACGAGCAAGGCTTGAACAATGCGCTTGAGCAGATTGGATTTTTCAGCAAGACCAT
TATGCCTGCACAGCGCCAAGCGATTCTTGATCTCGTCAAAATGGCGTGTGAACCTATGCTGGTTGATGAGCCTTATGACT
TCAAAGCCAGTGGCTTAGCTCAGAAACTCCGCGAGGCCGGTACCATTTTAAGCATGGAACAAGACTACTGGCACACGCCA
CCAGCAGATGCCCTATTCCTGCACAGAAAAATAGGCGGAATGTACTTGCTGGCAGCTCGCATTGGTGCAAAAGTGAACAT
TCGCCAATTGGTCTCACCGTACCTACAGATTATGGACGAATAG

Upstream 100 bases:

>100_bases
CTCCCAAACCGCCAGTTCCGCTGGCGGTTTTCTTTTCATTTGTATCCAAGCACGTAGTTTTCCCGTATAACAAATAGTTA
GTAAATAACGGAGAAAATTC

Downstream 100 bases:

>100_bases
ACTATTGTTTTTCTGCCACTTTCGAGTACCTTGAGCAGCTGCCTATAAGAATAATGTGACTGTCGGGGTGCTCGGTGAGT
AAGTTTCAAGACCTCTCCAC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSAKERSLPTHRISRFSKFASLATRVAGNVIAEGTKQIAKGNKPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMD
AGDVLEPDLADILSRLRSNADPMPAKQLNAVMENALGTNWKTEFLSFNFKPIASASIGQVHQAYSDAGDNLAVKVQYPGV
RKSIDSDVDNVGTLLKVVGLIPESVDYKGLLEEAKKQLHDEADYAREAHFAIRYHDALKDHPHFVVPKIHTGSSSDAVLA
MEFIDGSPIEQIEHYDQSTRDFVMHSLLELLFRELFEFKMVQTDPNFANYLYIENTRQIGLLDFGATREYSEQFSTGYRQ
AFASVVNDDEQGLNNALEQIGFFSKTIMPAQRQAILDLVKMACEPMLVDEPYDFKASGLAQKLREAGTILSMEQDYWHTP
PADALFLHRKIGGMYLLAARIGAKVNIRQLVSPYLQIMDE

Sequences:

>Translated_440_residues
MSAKERSLPTHRISRFSKFASLATRVAGNVIAEGTKQIAKGNKPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMD
AGDVLEPDLADILSRLRSNADPMPAKQLNAVMENALGTNWKTEFLSFNFKPIASASIGQVHQAYSDAGDNLAVKVQYPGV
RKSIDSDVDNVGTLLKVVGLIPESVDYKGLLEEAKKQLHDEADYAREAHFAIRYHDALKDHPHFVVPKIHTGSSSDAVLA
MEFIDGSPIEQIEHYDQSTRDFVMHSLLELLFRELFEFKMVQTDPNFANYLYIENTRQIGLLDFGATREYSEQFSTGYRQ
AFASVVNDDEQGLNNALEQIGFFSKTIMPAQRQAILDLVKMACEPMLVDEPYDFKASGLAQKLREAGTILSMEQDYWHTP
PADALFLHRKIGGMYLLAARIGAKVNIRQLVSPYLQIMDE
>Mature_439_residues
SAKERSLPTHRISRFSKFASLATRVAGNVIAEGTKQIAKGNKPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMDA
GDVLEPDLADILSRLRSNADPMPAKQLNAVMENALGTNWKTEFLSFNFKPIASASIGQVHQAYSDAGDNLAVKVQYPGVR
KSIDSDVDNVGTLLKVVGLIPESVDYKGLLEEAKKQLHDEADYAREAHFAIRYHDALKDHPHFVVPKIHTGSSSDAVLAM
EFIDGSPIEQIEHYDQSTRDFVMHSLLELLFRELFEFKMVQTDPNFANYLYIENTRQIGLLDFGATREYSEQFSTGYRQA
FASVVNDDEQGLNNALEQIGFFSKTIMPAQRQAILDLVKMACEPMLVDEPYDFKASGLAQKLREAGTILSMEQDYWHTPP
ADALFLHRKIGGMYLLAARIGAKVNIRQLVSPYLQIMDE

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=434, Percent_Identity=35.7142857142857, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI27363457, Length=435, Percent_Identity=34.2528735632184, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI217416386, Length=428, Percent_Identity=31.7757009345794, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI40254938, Length=292, Percent_Identity=29.7945205479452, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI217035081, Length=225, Percent_Identity=30.2222222222222, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI2367309, Length=283, Percent_Identity=26.8551236749117, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32565180, Length=437, Percent_Identity=34.0961098398169, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17559152, Length=284, Percent_Identity=27.4647887323944, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=429, Percent_Identity=38.4615384615385, Blast_Score=312, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6323282, Length=284, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859849, Length=426, Percent_Identity=34.7417840375587, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI22024280, Length=282, Percent_Identity=29.0780141843972, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24662575, Length=300, Percent_Identity=25.6666666666667, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49122; Mature: 48990

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKERSLPTHRISRFSKFASLATRVAGNVIAEGTKQIAKGNKPKAKDLLLTPQNIARLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHH
DQLAHLRGAAMKLGQMLSMDAGDVLEPDLADILSRLRSNADPMPAKQLNAVMENALGTNW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
KTEFLSFNFKPIASASIGQVHQAYSDAGDNLAVKVQYPGVRKSIDSDVDNVGTLLKVVGL
CHHHHEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHH
IPESVDYKGLLEEAKKQLHDEADYAREAHFAIRYHDALKDHPHFVVPKIHTGSSSDAVLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCEEEEEEECCCCCCCEEE
MEFIDGSPIEQIEHYDQSTRDFVMHSLLELLFRELFEFKMVQTDPNFANYLYIENTRQIG
EEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
LLDFGATREYSEQFSTGYRQAFASVVNDDEQGLNNALEQIGFFSKTIMPAQRQAILDLVK
EEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
MACEPMLVDEPYDFKASGLAQKLREAGTILSMEQDYWHTPPADALFLHRKIGGMYLLAAR
HHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCHHEEHHH
IGAKVNIRQLVSPYLQIMDE
HCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAKERSLPTHRISRFSKFASLATRVAGNVIAEGTKQIAKGNKPKAKDLLLTPQNIARLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHH
DQLAHLRGAAMKLGQMLSMDAGDVLEPDLADILSRLRSNADPMPAKQLNAVMENALGTNW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
KTEFLSFNFKPIASASIGQVHQAYSDAGDNLAVKVQYPGVRKSIDSDVDNVGTLLKVVGL
CHHHHEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHH
IPESVDYKGLLEEAKKQLHDEADYAREAHFAIRYHDALKDHPHFVVPKIHTGSSSDAVLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCCCCEEEEEEECCCCCCCEEE
MEFIDGSPIEQIEHYDQSTRDFVMHSLLELLFRELFEFKMVQTDPNFANYLYIENTRQIG
EEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEE
LLDFGATREYSEQFSTGYRQAFASVVNDDEQGLNNALEQIGFFSKTIMPAQRQAILDLVK
EEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
MACEPMLVDEPYDFKASGLAQKLREAGTILSMEQDYWHTPPADALFLHRKIGGMYLLAAR
HHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCCHHEEHHH
IGAKVNIRQLVSPYLQIMDE
HCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]