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The map label for this gene is kefC [H]

Identifier: 156976500

GI number: 156976500

Start: 517184

End: 519142

Strand: Reverse

Name: kefC [H]

Synonym: VIBHAR_05273

Alternate gene names: 156976500

Gene position: 519142-517184 (Counterclockwise)

Preceding gene: 156976501

Following gene: 156976495

Centisome position: 23.55

GC content: 48.65

Gene sequence:

>1959_bases
ATGACAGGGATATTCTTACAAGCCTTTGTTTACCTAATTGCCGCCGTAATTGCCGTTCCTCTAGCCAAACGCTTGGGCTT
AGGTTCAGTGCTGGGCTATTTGATTGCTGGCGTGGTTATTGGCCCAATTATTGGTCTGGTTGGTGAAGAAACGACGACAA
TCCAACACTTTGCCGAATTCGGTGTTGTGATGATGCTGTTCCTCGTAGGTTTGGAGCTTGAACCCAAAATGCTCTGGGCG
ATGCGAAACCGCTTGATGGGACTCGGTGGCCTACAAGTTGGCGGTACAGCAGCGCTGATCATGGCAATTGCGCTTTACTT
TGAACAACCATGGACGATTGCACTCGCGATCGGCTTAATTTTTGCGTTGTCATCCACTGCAATTGTGCTGCAAACCTTTA
ATGAGAAAGGGCTAACCAAGACCGAAGGCGGTCAAAATGCGTTCTCGGTACTGCTTTTCCAAGATATCGCGGTTATACCA
ATGCTGGCATTTATTCCGCTATTAGCACTGCCGGAACTCGTAGAGCAGGCACAATCTGCAGCTCAATCAGCAGCTGAACA
TCATGAAGAGCTCATCCTAGTCGCTGGTGTTCCTGGTTGGGCGTACGGTCTTGTGATCACCGCTTCTATTGCCATCGTGG
TGGTTGGTGGACACTTCCTGAGTCGTCCGCTGTTCCGCTACGTTGCTAGCTCTGGATTGCGCGAAATCTTTACCGCCACC
GCATTAATGCTGGTGATCGGCATTGCGGCCTTAATGAGCTTAGTTGGCCTATCCCCTGCTTTAGGCACTTTCTTGGCAGG
TGTTATGCTGGCGAACAGTGAATTCCGCCACGAATTGGAATCCAACATTGAGCCATTTAAAGGCCTATTGCTTGGTCTGT
TCTTTATCACCGTAGGTGCAGGCATCGACTTCTCAGTTCTGTTCAGCGACTTTGGTTTGATCATCGGCCTGACACTCGGG
GTAATGGCTCTGAAAGCGGTAATTCTGTTTGTCATCGCCCTAATCTTTCGTATTAAAGGCAGCAACCGTTGGTTATTTAC
ACTGAGCTTGGCACAAGCGGGTGAATTTGGCTTTGTATTACTGAGCTTCTCAGTGCAAAACCATGTAATTCCATTTGAGC
TTTCACAGACTCTGGCGCTGGTTGTTGCGATTTCAATGTTCCTAACGCCGGGATTATTCATCCTGTTCGATAAAGTCATA
CTTCCTCGCTTTGAGAGTGAATCGAACGATCGCGAAAGTGATACGATTGAAGAACAAGGCACCGTGATCATTGCTGGTAT
AGGCCGCTTTGGTCAGATCGTAAACCGCTTATTAGTATCCAATGGCGTGGAAACGGTTGTTCTTGACCACCAAGCAAGCC
AAATCGATAACATGCGTCAAATCGGCACACGAGCTTACTTTGGCGACGCGACTCGTCCCGATATGCTGCACACGGCGGGT
ATTGAGCACGCTTCAGCACTTGTGGTGGCGATTGACAACCAAGAGGCCAGCGTTGGATTGGTGAAACACGTGAAGCATAG
CTATCCGAATGTGACCATCATTGCACGTGCATTCGACCGTGGTCATGGTTATCTGCTGCGCCAAGCTGGAGCCGACATCA
TTGAGTCGGAGACTTACCATTCTGCATTAGAGATTGGTGGGCATGCAATGAAAGCCATTGGCATACACCCGTTCTACACT
GAGCAACAGAAATCAACGTATCGACGCGTCGAATGCCGTAAGTCTGACATGCTGTATGAAGCATGGGCCGATGACTCTGA
GGGAGAACGTTATGATAACAACTTCCGTCAGCTGTTTATTCACCTTGAAGAGAGAATGGCTGAAGAGATGCAGAAAGATC
GTCATGACAAACTTTCTCGCTCAGAACGTGGTTGGACACCGCCACCAAAAGGGTATGCGGATGACTTCAACGAAGAAAAC
GTTCAAGAGCTGAACCCTTGCAAAGAACAGCCTCAATAA

Upstream 100 bases:

>100_bases
CGCTGCTCAATGCATTGGTAAAAGACACATTGGATCTTAAAGCAGCAGCTTCACTCATCAAACTCAATAGCGCACTCCCA
CAACTGATTAAGGAAGCGTC

Downstream 100 bases:

>100_bases
AAGCAAAAACCTCCCACGCTGGGCTGTCTCTTGATCACAAGTCTAGTGATCAAGAGACATTGCGAGTTCGTAGCCCTCAA
GGATGGTTTGTAATTTAAAC

Product: hypothetical protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MTGIFLQAFVYLIAAVIAVPLAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWA
MRNRLMGLGGLQVGGTAALIMAIALYFEQPWTIALAIGLIFALSSTAIVLQTFNEKGLTKTEGGQNAFSVLLFQDIAVIP
MLAFIPLLALPELVEQAQSAAQSAAEHHEELILVAGVPGWAYGLVITASIAIVVVGGHFLSRPLFRYVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVMLANSEFRHELESNIEPFKGLLLGLFFITVGAGIDFSVLFSDFGLIIGLTLG
VMALKAVILFVIALIFRIKGSNRWLFTLSLAQAGEFGFVLLSFSVQNHVIPFELSQTLALVVAISMFLTPGLFILFDKVI
LPRFESESNDRESDTIEEQGTVIIAGIGRFGQIVNRLLVSNGVETVVLDHQASQIDNMRQIGTRAYFGDATRPDMLHTAG
IEHASALVVAIDNQEASVGLVKHVKHSYPNVTIIARAFDRGHGYLLRQAGADIIESETYHSALEIGGHAMKAIGIHPFYT
EQQKSTYRRVECRKSDMLYEAWADDSEGERYDNNFRQLFIHLEERMAEEMQKDRHDKLSRSERGWTPPPKGYADDFNEEN
VQELNPCKEQPQ

Sequences:

>Translated_652_residues
MTGIFLQAFVYLIAAVIAVPLAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWA
MRNRLMGLGGLQVGGTAALIMAIALYFEQPWTIALAIGLIFALSSTAIVLQTFNEKGLTKTEGGQNAFSVLLFQDIAVIP
MLAFIPLLALPELVEQAQSAAQSAAEHHEELILVAGVPGWAYGLVITASIAIVVVGGHFLSRPLFRYVASSGLREIFTAT
ALMLVIGIAALMSLVGLSPALGTFLAGVMLANSEFRHELESNIEPFKGLLLGLFFITVGAGIDFSVLFSDFGLIIGLTLG
VMALKAVILFVIALIFRIKGSNRWLFTLSLAQAGEFGFVLLSFSVQNHVIPFELSQTLALVVAISMFLTPGLFILFDKVI
LPRFESESNDRESDTIEEQGTVIIAGIGRFGQIVNRLLVSNGVETVVLDHQASQIDNMRQIGTRAYFGDATRPDMLHTAG
IEHASALVVAIDNQEASVGLVKHVKHSYPNVTIIARAFDRGHGYLLRQAGADIIESETYHSALEIGGHAMKAIGIHPFYT
EQQKSTYRRVECRKSDMLYEAWADDSEGERYDNNFRQLFIHLEERMAEEMQKDRHDKLSRSERGWTPPPKGYADDFNEEN
VQELNPCKEQPQ
>Mature_651_residues
TGIFLQAFVYLIAAVIAVPLAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEFGVVMMLFLVGLELEPKMLWAM
RNRLMGLGGLQVGGTAALIMAIALYFEQPWTIALAIGLIFALSSTAIVLQTFNEKGLTKTEGGQNAFSVLLFQDIAVIPM
LAFIPLLALPELVEQAQSAAQSAAEHHEELILVAGVPGWAYGLVITASIAIVVVGGHFLSRPLFRYVASSGLREIFTATA
LMLVIGIAALMSLVGLSPALGTFLAGVMLANSEFRHELESNIEPFKGLLLGLFFITVGAGIDFSVLFSDFGLIIGLTLGV
MALKAVILFVIALIFRIKGSNRWLFTLSLAQAGEFGFVLLSFSVQNHVIPFELSQTLALVVAISMFLTPGLFILFDKVIL
PRFESESNDRESDTIEEQGTVIIAGIGRFGQIVNRLLVSNGVETVVLDHQASQIDNMRQIGTRAYFGDATRPDMLHTAGI
EHASALVVAIDNQEASVGLVKHVKHSYPNVTIIARAFDRGHGYLLRQAGADIIESETYHSALEIGGHAMKAIGIHPFYTE
QQKSTYRRVECRKSDMLYEAWADDSEGERYDNNFRQLFIHLEERMAEEMQKDRHDKLSRSERGWTPPPKGYADDFNEENV
QELNPCKEQPQ

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=416, Percent_Identity=26.6826923076923, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1786232, Length=631, Percent_Identity=42.3137876386688, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789749, Length=626, Percent_Identity=39.297124600639, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1786685, Length=556, Percent_Identity=29.3165467625899, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 71298; Mature: 71167

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIFLQAFVYLIAAVIAVPLAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEF
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWAMRNRLMGLGGLQVGGTAALIMAIALYFEQPWTIALAIGLI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
FALSSTAIVLQTFNEKGLTKTEGGQNAFSVLLFQDIAVIPMLAFIPLLALPELVEQAQSA
HHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSAAEHHEELILVAGVPGWAYGLVITASIAIVVVGGHFLSRPLFRYVASSGLREIFTAT
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVMLANSEFRHELESNIEPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GIDFSVLFSDFGLIIGLTLGVMALKAVILFVIALIFRIKGSNRWLFTLSLAQAGEFGFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEE
LSFSVQNHVIPFELSQTLALVVAISMFLTPGLFILFDKVILPRFESESNDRESDTIEEQG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCC
TVIIAGIGRFGQIVNRLLVSNGVETVVLDHQASQIDNMRQIGTRAYFGDATRPDMLHTAG
CEEEEECHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHCCCCCCCCHHHHHC
IEHASALVVAIDNQEASVGLVKHVKHSYPNVTIIARAFDRGHGYLLRQAGADIIESETYH
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCCHHHHHCCCHHHHHHHHH
SALEIGGHAMKAIGIHPFYTEQQKSTYRRVECRKSDMLYEAWADDSEGERYDNNFRQLFI
HHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
HLEERMAEEMQKDRHDKLSRSERGWTPPPKGYADDFNEENVQELNPCKEQPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
TGIFLQAFVYLIAAVIAVPLAKRLGLGSVLGYLIAGVVIGPIIGLVGEETTTIQHFAEF
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
GVVMMLFLVGLELEPKMLWAMRNRLMGLGGLQVGGTAALIMAIALYFEQPWTIALAIGLI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
FALSSTAIVLQTFNEKGLTKTEGGQNAFSVLLFQDIAVIPMLAFIPLLALPELVEQAQSA
HHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSAAEHHEELILVAGVPGWAYGLVITASIAIVVVGGHFLSRPLFRYVASSGLREIFTAT
HHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHH
ALMLVIGIAALMSLVGLSPALGTFLAGVMLANSEFRHELESNIEPFKGLLLGLFFITVGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GIDFSVLFSDFGLIIGLTLGVMALKAVILFVIALIFRIKGSNRWLFTLSLAQAGEFGFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEE
LSFSVQNHVIPFELSQTLALVVAISMFLTPGLFILFDKVILPRFESESNDRESDTIEEQG
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCC
TVIIAGIGRFGQIVNRLLVSNGVETVVLDHQASQIDNMRQIGTRAYFGDATRPDMLHTAG
CEEEEECHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHCCCCCCCCHHHHHC
IEHASALVVAIDNQEASVGLVKHVKHSYPNVTIIARAFDRGHGYLLRQAGADIIESETYH
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEHHCCCCHHHHHCCCHHHHHHHHH
SALEIGGHAMKAIGIHPFYTEQQKSTYRRVECRKSDMLYEAWADDSEGERYDNNFRQLFI
HHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
HLEERMAEEMQKDRHDKLSRSERGWTPPPKGYADDFNEENVQELNPCKEQPQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA