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The map label for this gene is moeA [C]

Identifier: 156938177

GI number: 156938177

Start: 1250761

End: 1251969

Strand: Direct

Name: moeA [C]

Synonym: Igni_1390

Alternate gene names: 156938177

Gene position: 1250761-1251969 (Clockwise)

Preceding gene: 156938174

Following gene: 156938184

Centisome position: 96.39

GC content: 59.47

Gene sequence:

>1209_bases
TTGCCCGGCTTGAAGAAGCTACACCCCGTCCCCTACGTGATTGACGAAATAAGCAAGAGGTTGGGCCCCGCACCGCTCGA
GAGGATCAAGACAGTAGAATCAGTGGGCATGTTCTCGGGCTCAGACGTGAGGGCCTCACAAGACGTCCCTCCAGAAGACA
AGGCCGTCTTGGACGGGTTCGCGGTGAACAGCGAATTCGTAGAGGACTGCAGCGAGACGTCGCCGTGTAAGTTGAAGTTG
TGTGGGGAGGCTGAGGGCGGCTGTGCGGTCCCGGTCAACACGGGTAACCCCTTGCCGCCGGGAGCTGACACGGTAGTGCC
CATCGAGGCTTGTAAGGTCGAGGACGGCGAGGTATACGTCTTCCGCCCCTTCCCGCCGGGCAACGCGATAGCGAAGAGGG
GGGAGGACCTAAAGTCTGGGGACACAATAATAACGAAAGGAACGTACCTCAGGCCTTGGCACGTGGCCGCCTTGTTATCT
CAAGGGGTAGTCGAGGTAGACGTGGTAGCGCCCAAAATAGCCTTAGCGGCCACGGGTTCGGAATTGGTAGAGCCGTGGGA
GGAGAGGGAAGGCGTGAAGAACACCACGGCGTGGCTGGCCTCCTCTTTCTTTAAAGAGAGGATGGGCATCAAAGTGGATT
ACTTCGGCATAATTGAAGACGACAAAGAAGCTATAAGAGAGTTCTTCGAGAAGAAGGTGAAGGAGGGCTACGACATTGTA
ATGACCACCGGGGGGACCTCCGTCGGTCGCGTCGACTTCACCTCGTCCGCGCTGAAAGAGGTCTCTGAGTTCAGCCTTCA
CGGCGTCGCCCTCACCCCGGGCAGGCCCCTCGCCGTGGGGGTGAGCGAGGGCGGCAAGCTGTTGGTAGCCCTTTCCGGCT
ACCCCGTGGCCGCGCTCAGCGAGCTTGAGGTCGTCGTGTGGAACATCCTAAAGAGGGCTTGGGGTCTCAAGGAGCCCCCG
AGGCCCAAGGTTAAGGCGAAGCTGGCTAGGAGGCTGCCGGTCCAACCCAACATGGTCCACGTCTACAGGGTAGTCGTGAG
GAAGGTCGGTGAGGAGTACGTCGTAGAGCCCTTGAGGCTCACGGGTTCGGGTATTCTCTCGTCACTACTCAAGGGAAACG
GGATCTTGGTGGCGGGTCTCAAGGGCGAGACCGGGTACGACGTGGGCGCCGAAGTCGAGGTAGAGTTGATCTCCGAGGTG
TTAGAGTGA

Upstream 100 bases:

>100_bases
CGGCAGAGCGCCCGGCTGATAACCGGGAGGCCGGGGGTTCAAATCCCCCCGGGCCCACTAAACCTCCCGCCCAATCACCT
CAAAGCGGGAAGGAGAGGCT

Downstream 100 bases:

>100_bases
GTGGTCAACTCGTGGCGCCGGGGGCGGGATTCGAACCCGCGCGCCCCTGATTGGGGCAGTGGGTCTCTCGGTCGCTTCGG
GCGCTGGAGGTCTCGAGCCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MPGLKKLHPVPYVIDEISKRLGPAPLERIKTVESVGMFSGSDVRASQDVPPEDKAVLDGFAVNSEFVEDCSETSPCKLKL
CGEAEGGCAVPVNTGNPLPPGADTVVPIEACKVEDGEVYVFRPFPPGNAIAKRGEDLKSGDTIITKGTYLRPWHVAALLS
QGVVEVDVVAPKIALAATGSELVEPWEEREGVKNTTAWLASSFFKERMGIKVDYFGIIEDDKEAIREFFEKKVKEGYDIV
MTTGGTSVGRVDFTSSALKEVSEFSLHGVALTPGRPLAVGVSEGGKLLVALSGYPVAALSELEVVVWNILKRAWGLKEPP
RPKVKAKLARRLPVQPNMVHVYRVVVRKVGEEYVVEPLRLTGSGILSSLLKGNGILVAGLKGETGYDVGAEVEVELISEV
LE

Sequences:

>Translated_402_residues
MPGLKKLHPVPYVIDEISKRLGPAPLERIKTVESVGMFSGSDVRASQDVPPEDKAVLDGFAVNSEFVEDCSETSPCKLKL
CGEAEGGCAVPVNTGNPLPPGADTVVPIEACKVEDGEVYVFRPFPPGNAIAKRGEDLKSGDTIITKGTYLRPWHVAALLS
QGVVEVDVVAPKIALAATGSELVEPWEEREGVKNTTAWLASSFFKERMGIKVDYFGIIEDDKEAIREFFEKKVKEGYDIV
MTTGGTSVGRVDFTSSALKEVSEFSLHGVALTPGRPLAVGVSEGGKLLVALSGYPVAALSELEVVVWNILKRAWGLKEPP
RPKVKAKLARRLPVQPNMVHVYRVVVRKVGEEYVVEPLRLTGSGILSSLLKGNGILVAGLKGETGYDVGAEVEVELISEV
LE
>Mature_401_residues
PGLKKLHPVPYVIDEISKRLGPAPLERIKTVESVGMFSGSDVRASQDVPPEDKAVLDGFAVNSEFVEDCSETSPCKLKLC
GEAEGGCAVPVNTGNPLPPGADTVVPIEACKVEDGEVYVFRPFPPGNAIAKRGEDLKSGDTIITKGTYLRPWHVAALLSQ
GVVEVDVVAPKIALAATGSELVEPWEEREGVKNTTAWLASSFFKERMGIKVDYFGIIEDDKEAIREFFEKKVKEGYDIVM
TTGGTSVGRVDFTSSALKEVSEFSLHGVALTPGRPLAVGVSEGGKLLVALSGYPVAALSELEVVVWNILKRAWGLKEPPR
PKVKAKLARRLPVQPNMVHVYRVVVRKVGEEYVVEPLRLTGSGILSSLLKGNGILVAGLKGETGYDVGAEVEVELISEVL
E

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=27.3417721518987, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=27.3417721518987, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=29.6875, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147659, Length=407, Percent_Identity=25.7985257985258, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136978, Length=339, Percent_Identity=27.1386430678466, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24638841, Length=339, Percent_Identity=27.1386430678466, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43245; Mature: 43114

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLKKLHPVPYVIDEISKRLGPAPLERIKTVESVGMFSGSDVRASQDVPPEDKAVLDGF
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCC
AVNSEFVEDCSETSPCKLKLCGEAEGGCAVPVNTGNPLPPGADTVVPIEACKVEDGEVYV
CCCHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEHEEECCCCCEEE
FRPFPPGNAIAKRGEDLKSGDTIITKGTYLRPWHVAALLSQGVVEVDVVAPKIALAATGS
EECCCCCHHHHHCCCCCCCCCEEEECCCEECHHHHHHHHHCCCEEEEEECCEEEEEECCH
ELVEPWEEREGVKNTTAWLASSFFKERMGIKVDYFGIIEDDKEAIREFFEKKVKEGYDIV
HHHCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEE
MTTGGTSVGRVDFTSSALKEVSEFSLHGVALTPGRPLAVGVSEGGKLLVALSGYPVAALS
EECCCCCCCEEECCHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEECCCCHHHHH
ELEVVVWNILKRAWGLKEPPRPKVKAKLARRLPVQPNMVHVYRVVVRKVGEEYVVEPLRL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHCCCHHC
TGSGILSSLLKGNGILVAGLKGETGYDVGAEVEVELISEVLE
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHC
>Mature Secondary Structure 
PGLKKLHPVPYVIDEISKRLGPAPLERIKTVESVGMFSGSDVRASQDVPPEDKAVLDGF
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCC
AVNSEFVEDCSETSPCKLKLCGEAEGGCAVPVNTGNPLPPGADTVVPIEACKVEDGEVYV
CCCHHHHHHHCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCEEEEHEEECCCCCEEE
FRPFPPGNAIAKRGEDLKSGDTIITKGTYLRPWHVAALLSQGVVEVDVVAPKIALAATGS
EECCCCCHHHHHCCCCCCCCCEEEECCCEECHHHHHHHHHCCCEEEEEECCEEEEEECCH
ELVEPWEEREGVKNTTAWLASSFFKERMGIKVDYFGIIEDDKEAIREFFEKKVKEGYDIV
HHHCCHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEE
MTTGGTSVGRVDFTSSALKEVSEFSLHGVALTPGRPLAVGVSEGGKLLVALSGYPVAALS
EECCCCCCCEEECCHHHHHHHHHHHCCCEEECCCCCEEEEECCCCEEEEEECCCCHHHHH
ELEVVVWNILKRAWGLKEPPRPKVKAKLARRLPVQPNMVHVYRVVVRKVGEEYVVEPLRL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHCCCHHC
TGSGILSSLLKGNGILVAGLKGETGYDVGAEVEVELISEVLE
CHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]