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The map label for this gene is purL

Identifier: 156938039

GI number: 156938039

Start: 1111835

End: 1113976

Strand: Reverse

Name: purL

Synonym: Igni_1252

Alternate gene names: 156938039

Gene position: 1113976-1111835 (Counterclockwise)

Preceding gene: 156938040

Following gene: 156938037

Centisome position: 85.85

GC content: 61.48

Gene sequence:

>2142_bases
TTGCCGCTCACGGAAGAGGAGCTGAAGCTCATTGAAGAGACTCTGGGGAGGAAGCCGAACCAAGTGGAGCTCGCCATGTT
CGAGGCGCAGTGGAGCGAGCACTGTTCCTACAAGAGCTCGAGGAAGCACTTGAGGAAGCTGAAGATGGACTCGCCGTGGG
TCGTGAAGGGCGGCGACGCGGCGGTGGTGGACTTCGGCTCGGTTTACGTTGCTTTTAGAATAGAGAGCCACAACCACCCC
TCTGCGGTGGACCCCTACAACGGGGCGGCCACGGGGGTTGGAGGTATAATTAGAGACATCCTGAGCTCCGGCGCGAAGCC
TATAGCGCTCCTCGACGACCTAATATTCGGAGACTTGGACGAGAATTTGGTCAAGTGGCACGTTAAGGGGGTCGTAAAGG
GGATATCCGACTACGGCAACAGGGTGGGCGTTCCTACGGTCGGCGGGGAGACTTGGTTCGACCCCGACTTCACGAGGAAC
CCGATGGTCTCCGTAGCTTGTGTGGGCGTGTGCCCCAAGGACAAACTCATAAACGGCACCCCTAGGCCGGGCGACCTAAT
AGTAATCGCCGGAAACTACACGGGCAAGGACGGCCTATTGGGTTCCTCGTTCGCCTCTAAGAACTTGGAGGAGGGGGTGG
AGGAGGAGTACGCGGCGATACAAGTCCCCGACCCCCTCATGGAGAAGCTCTTGATCGATTCGATATTGGAAATGAGGGAC
GAGAGGCTGTTGGTTTTCGTGAAGGACTTGGGCGGCGGAGGGCTCGCGACGGCCCTCAGCGAGGTCGCGGCGAGCTTCGG
CTTGGGGGTGGAGGCGCGGCTCGACGCTTTACACTTGCGCGAGCCCATGGAAGCTTGGGAAATAGTAGTTTCGGAGAGCC
AAGAGAGGATGATGTTGGTAATTAGGCCGGAGGACCTAGAGAGGGCGAAGAAGGTGCTCGAAAAGTACGACGTCCCCTAC
AGCGTCATAGGGAAGTTCACGGACACCGGGAGGGTGGTCTTGTATTACAACGGCGAGAAGGTGGCGGACTTGCCGGCCAA
GTTCTTGGCCGAGGGCCCGGAGCTGGACAGGCCTTACGAGAGGCCCAAGTGGCACCTCGAGCTGGAGCTCCTCCCCCCGC
TCCCCGAGGTAGATCTGGGGGACGCGATCAGAAAGGTGCTGAGCTCTCCGAACGTGGCCTCTAAGAGGTGGATATACGAG
CAGTACGACCACGAGGTCCAGATAAGGACCGTGGTGAAGCCCGGCGAGGGGGACGCGGCGGTACTGAGGCTCTTGGAGGA
CCCCCCTAAGGGAATAGCCGTAGCTACGGACTCCAACCCCCGTTACACGTTCTTGGACCCGCTCTGGGGCGCGGCGGACG
TCTTTCTGGAGGCCTACCGGAACGTGGTGGCCTCGGGGGCCAGGCCGCTGGCCGCGGTGGACCAAGTGGACGCGGGCAGC
CCGGAGAGGCCCGACCGCTTCTGGTTCTTCGTGAGGATGATCGACGGACTGGCTTGGGTGGAACGGGAGGTGGACGTACC
CATAGTGGGGGGCAAGGTGAGCTTCTACAACGAGGACGACGTAACTGGCAAGCAGATAAAGCCGACTGTCATGATAACGA
TGATAGGAAAGGTGGAGAACGTCTACAACGCGAAGAGGGCCCGCGCGGAGGAGGGCGACCTCTTGGTTCTGGTAGGCGAG
ACCTTCCCGGAGCTGGGAGGGAGCGAGTTCCTGTGGAGCGTCCACAAGCTCGTGAGGGGGAAGCCTCCCGTCCCGAGGCC
CTCTACCGAAGCGAGGGTAGCGGAGAGGATACTCAAGGCAATAAAGGTATCCGGGGTCACGGGGGTCCACGACGTGTCCG
TCGGGGGCTTGGCGGCGGCGGTGGCGGAGCTCGCGAAGGGGTTCGGGGCCACGCTCGAGTTGGACAAGGTCAAGGGGCCT
TGGAAGAGGCCCGAGGAGGCGCTGTTCTCCGAGAGCGGGGCTAGGTACTTGTTGGCGGTTAAGCCGGAAGCCGCGGAGGA
GGTCTTGAAGGTCACCGGAGGTACGGTAGTCGGTAAGGTGGGCGGGGGCCCGCTGAGGGTGCTCTTGAATGGGAAAGAAG
TGGCCTCGGTGGACGACTTCGAGGACCTCTTGGAGAACGGCATGACCTCCCGCCTAGTCTAG

Upstream 100 bases:

>100_bases
TACTTGTGGAAGCTCAACGTAGACAACGTCGTCAAAGTTTTCGGCGTAACCCCGCCCTAACCGTCTAAACCCGTCGTTAG
CCGCCCCGACGGGCAGCGCC

Downstream 100 bases:

>100_bases
CGGGGTCCTCCCGGTCCTCAACATGGACTCTATAACGTCCGGGCTCCGCTTAAACTTCCTTACCTTAACTACGACCCAGC
CTCCCTCCTCCCACTTTTCT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 713; Mature: 712

Protein sequence:

>713_residues
MPLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDAAVVDFGSVYVAFRIESHNHP
SAVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLDENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRN
PMVSVACVGVCPKDKLINGTPRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRD
ERLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLVIRPEDLERAKKVLEKYDVPY
SVIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYERPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYE
QYDHEVQIRTVVKPGEGDAAVLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGS
PERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVENVYNAKRARAEEGDLLVLVGE
TFPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKAIKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGP
WKRPEEALFSESGARYLLAVKPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV

Sequences:

>Translated_713_residues
MPLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDAAVVDFGSVYVAFRIESHNHP
SAVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLDENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRN
PMVSVACVGVCPKDKLINGTPRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRD
ERLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLVIRPEDLERAKKVLEKYDVPY
SVIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYERPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYE
QYDHEVQIRTVVKPGEGDAAVLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGS
PERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVENVYNAKRARAEEGDLLVLVGE
TFPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKAIKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGP
WKRPEEALFSESGARYLLAVKPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV
>Mature_712_residues
PLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDAAVVDFGSVYVAFRIESHNHPS
AVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLDENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRNP
MVSVACVGVCPKDKLINGTPRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRDE
RLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLVIRPEDLERAKKVLEKYDVPYS
VIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYERPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYEQ
YDHEVQIRTVVKPGEGDAAVLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGSP
ERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVENVYNAKRARAEEGDLLVLVGET
FPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKAIKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGPW
KRPEEALFSESGARYLLAVKPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=635, Percent_Identity=23.9370078740157, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI48994899, Length=811, Percent_Identity=24.7842170160296, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17553022, Length=766, Percent_Identity=23.6292428198433, Blast_Score=99, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=475, Percent_Identity=25.8947368421053, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24582111, Length=754, Percent_Identity=24.2705570291777, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582109, Length=754, Percent_Identity=24.2705570291777, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137292, Length=754, Percent_Identity=24.2705570291777, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_IGNH4 (A8ABX6)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435835.1
- ProteinModelPortal:   A8ABX6
- SMR:   A8ABX6
- STRING:   A8ABX6
- GeneID:   5562767
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_1252
- eggNOG:   arNOG04101
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   IHOS453591:IGNI_1252-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 77919; Mature: 77788

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDA
CCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCE
AVVDFGSVYVAFRIESHNHPSAVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLD
EEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
ENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRNPMVSVACVGVCPKDKLINGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
PRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRD
CCCCCEEEEECCCCCCCCCCCCHHHHCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCC
ERLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLV
CEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
IRPEDLERAKKVLEKYDVPYSVIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYE
ECCHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCHHCCHHHHHCCCCCCCCCC
RPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYEQYDHEVQIRTVVKPGEGDAA
CCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEECCCCHHH
VLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGS
HHHHHCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
PERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVEN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCCCEEEEEEHHHHHH
VYNAKRARAEEGDLLVLVGETFPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKA
HHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGPWKRPEEALFSESGARYLLAV
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEEE
KPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV
CCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
PLTEEELKLIEETLGRKPNQVELAMFEAQWSEHCSYKSSRKHLRKLKMDSPWVVKGGDA
CCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCE
AVVDFGSVYVAFRIESHNHPSAVDPYNGAATGVGGIIRDILSSGAKPIALLDDLIFGDLD
EEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
ENLVKWHVKGVVKGISDYGNRVGVPTVGGETWFDPDFTRNPMVSVACVGVCPKDKLINGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
PRPGDLIVIAGNYTGKDGLLGSSFASKNLEEGVEEEYAAIQVPDPLMEKLLIDSILEMRD
CCCCCEEEEECCCCCCCCCCCCHHHHCHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCC
ERLLVFVKDLGGGGLATALSEVAASFGLGVEARLDALHLREPMEAWEIVVSESQERMMLV
CEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEE
IRPEDLERAKKVLEKYDVPYSVIGKFTDTGRVVLYYNGEKVADLPAKFLAEGPELDRPYE
ECCHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCHHCCHHHHHCCCCCCCCCC
RPKWHLELELLPPLPEVDLGDAIRKVLSSPNVASKRWIYEQYDHEVQIRTVVKPGEGDAA
CCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEECCCCHHH
VLRLLEDPPKGIAVATDSNPRYTFLDPLWGAADVFLEAYRNVVASGARPLAAVDQVDAGS
HHHHHCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
PERPDRFWFFVRMIDGLAWVEREVDVPIVGGKVSFYNEDDVTGKQIKPTVMITMIGKVEN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCCCEEEEEEHHHHHH
VYNAKRARAEEGDLLVLVGETFPELGGSEFLWSVHKLVRGKPPVPRPSTEARVAERILKA
HHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IKVSGVTGVHDVSVGGLAAAVAELAKGFGATLELDKVKGPWKRPEEALFSESGARYLLAV
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEEE
KPEAAEEVLKVTGGTVVGKVGGGPLRVLLNGKEVASVDDFEDLLENGMTSRLV
CCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA