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The map label for this gene is top6A [H]

Identifier: 156937842

GI number: 156937842

Start: 937033

End: 938175

Strand: Reverse

Name: top6A [H]

Synonym: Igni_1053

Alternate gene names: 156937842

Gene position: 938175-937033 (Counterclockwise)

Preceding gene: 156937843

Following gene: 156937841

Centisome position: 72.3

GC content: 52.14

Gene sequence:

>1143_bases
GTGGCTTCCCAAGTAGACTTAATGGCGCGCAAGAGAGCGATAAACACCTTCTTCGAGAAGTTCAAGGTGCTTATAGATAA
AATAAGGAAGGGGGAGGAGCCCGCGCTGGAGATACTGTCCAGAACCAAGGCGAACGTGGTTTACGACAGCGACAAGAAGA
TGCTGATGCCGGGCGAGAGGACAATACTGAGGAAGTTCTTGGACAAGGGGGAGGCCAAGAAGTTCACTAACACCCTCCTC
ATGGCTTCCTTGATATATGAGGCCTTGTTGAACGACGAGTACCCGACCATACGTGACTTGTACTACAGAGGCAAGCACAC
CATAATCTACAGGGACCTAAGGGGGAGAAAGAGGGAAGAGAACACTTGGGACGAGCAGAAGGAGAGCGACGCGCTGATAG
TGGACGTAGAGGTATACACCGGAATGTTGAGGGAGGAGATGTTAATATTGAGTAAGGAGAAGGGCAAGGTAGTAGGCGAC
ATGAGAATAAGGTCCGGCGACGACGTGATAGACTTGAGCAAGATGGGTCACGGCGCCTACGCGATAGAGCCCACCCCGGA
CTTGATAGACTTCATAGACGTGAACGCAGAGTATGTACTAGTAATAGAGAAGGACGCGGTCTTTCAGCAGCTCCACAGGA
TAAAGTTCTGGCAGAGGAACAACTGCATACTCATCAGCACCTCCGGCCAGCCGGACAGGGCGACCAGGAGGTTCATAAGG
AGGTTAAACGAAGAGTTGGGCCTCCCGGTTTACGTCCTCACGGACGCCGACCCCTACGGGTGGTACATCTTCAGCGTGAT
AAGGTCAGGCAGCATAAACCTGAGCTTCGAGAGCGAGAGGCTCGCCACCCCGAACGCGAAGTTCCTCGGGGTCAGCATGA
GCGACGTGTTCGAGAAGAACTGGCTGAGCCCGAAGGAGAGGAAGAACGTTATAATAGTTGCTAAGGACAGAGACATCAAG
AGGGCCTACGAGATGATGAAGTACGAGTGGTTCAAGAACTCTCCGAAGTGGATGCACGAGCTCAAGCTGTTCTTAAAAGA
GAAGAAGAAGCTAGAGATAGAGGCCCTAGCGGTTAAGGGCTTGAAGTTCCTCGCCGAAGTTTACTTGCCTCAGAAGATCC
AGACGAAGGACTGGATCGAGTGA

Upstream 100 bases:

>100_bases
CCCTTCCAACCGCCTCGAGGGCAGAAGCTCTATATAGAGAAGGACGTGGCCTTCAGCCTCTCTTAATTAACCTCTTTAAA
TATTTGACGTGGGGTGGACC

Downstream 100 bases:

>100_bases
GCCCGGCGGTAACTCACCTAATTAGTGTGAGTTACGCCGTACTCGCCGGGAGGGACGCTTGAGGGCTCTCTTGGCCGCGC
TGACCTTAATTGTGGTGACC

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit A [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MASQVDLMARKRAINTFFEKFKVLIDKIRKGEEPALEILSRTKANVVYDSDKKMLMPGERTILRKFLDKGEAKKFTNTLL
MASLIYEALLNDEYPTIRDLYYRGKHTIIYRDLRGRKREENTWDEQKESDALIVDVEVYTGMLREEMLILSKEKGKVVGD
MRIRSGDDVIDLSKMGHGAYAIEPTPDLIDFIDVNAEYVLVIEKDAVFQQLHRIKFWQRNNCILISTSGQPDRATRRFIR
RLNEELGLPVYVLTDADPYGWYIFSVIRSGSINLSFESERLATPNAKFLGVSMSDVFEKNWLSPKERKNVIIVAKDRDIK
RAYEMMKYEWFKNSPKWMHELKLFLKEKKKLEIEALAVKGLKFLAEVYLPQKIQTKDWIE

Sequences:

>Translated_380_residues
MASQVDLMARKRAINTFFEKFKVLIDKIRKGEEPALEILSRTKANVVYDSDKKMLMPGERTILRKFLDKGEAKKFTNTLL
MASLIYEALLNDEYPTIRDLYYRGKHTIIYRDLRGRKREENTWDEQKESDALIVDVEVYTGMLREEMLILSKEKGKVVGD
MRIRSGDDVIDLSKMGHGAYAIEPTPDLIDFIDVNAEYVLVIEKDAVFQQLHRIKFWQRNNCILISTSGQPDRATRRFIR
RLNEELGLPVYVLTDADPYGWYIFSVIRSGSINLSFESERLATPNAKFLGVSMSDVFEKNWLSPKERKNVIIVAKDRDIK
RAYEMMKYEWFKNSPKWMHELKLFLKEKKKLEIEALAVKGLKFLAEVYLPQKIQTKDWIE
>Mature_379_residues
ASQVDLMARKRAINTFFEKFKVLIDKIRKGEEPALEILSRTKANVVYDSDKKMLMPGERTILRKFLDKGEAKKFTNTLLM
ASLIYEALLNDEYPTIRDLYYRGKHTIIYRDLRGRKREENTWDEQKESDALIVDVEVYTGMLREEMLILSKEKGKVVGDM
RIRSGDDVIDLSKMGHGAYAIEPTPDLIDFIDVNAEYVLVIEKDAVFQQLHRIKFWQRNNCILISTSGQPDRATRRFIRR
LNEELGLPVYVLTDADPYGWYIFSVIRSGSINLSFESERLATPNAKFLGVSMSDVFEKNWLSPKERKNVIIVAKDRDIKR
AYEMMKYEWFKNSPKWMHELKLFLKEKKKLEIEALAVKGLKFLAEVYLPQKIQTKDWIE

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=359, Percent_Identity=28.6908077994429, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI38201680, Length=310, Percent_Identity=30, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17542064, Length=301, Percent_Identity=24.9169435215947, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552753, Length=313, Percent_Identity=31.3099041533546, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 44531; Mature: 44400

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASQVDLMARKRAINTFFEKFKVLIDKIRKGEEPALEILSRTKANVVYDSDKKMLMPGER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCEECCCHH
TILRKFLDKGEAKKFTNTLLMASLIYEALLNDEYPTIRDLYYRGKHTIIYRDLRGRKREE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCCCCC
NTWDEQKESDALIVDVEVYTGMLREEMLILSKEKGKVVGDMRIRSGDDVIDLSKMGHGAY
CCCCHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHCCCCEE
AIEPTPDLIDFIDVNAEYVLVIEKDAVFQQLHRIKFWQRNNCILISTSGQPDRATRRFIR
EECCCCCHHHHEECCCEEEEEEECHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHH
RLNEELGLPVYVLTDADPYGWYIFSVIRSGSINLSFESERLATPNAKFLGVSMSDVFEKN
HHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCHHHHHHHH
WLSPKERKNVIIVAKDRDIKRAYEMMKYEWFKNSPKWMHELKLFLKEKKKLEIEALAVKG
CCCHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LKFLAEVYLPQKIQTKDWIE
HHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ASQVDLMARKRAINTFFEKFKVLIDKIRKGEEPALEILSRTKANVVYDSDKKMLMPGER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCCCEECCCHH
TILRKFLDKGEAKKFTNTLLMASLIYEALLNDEYPTIRDLYYRGKHTIIYRDLRGRKREE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCCCCC
NTWDEQKESDALIVDVEVYTGMLREEMLILSKEKGKVVGDMRIRSGDDVIDLSKMGHGAY
CCCCHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEHHHCCCCEE
AIEPTPDLIDFIDVNAEYVLVIEKDAVFQQLHRIKFWQRNNCILISTSGQPDRATRRFIR
EECCCCCHHHHEECCCEEEEEEECHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHH
RLNEELGLPVYVLTDADPYGWYIFSVIRSGSINLSFESERLATPNAKFLGVSMSDVFEKN
HHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCHHHHHHHH
WLSPKERKNVIIVAKDRDIKRAYEMMKYEWFKNSPKWMHELKLFLKEKKKLEIEALAVKG
CCCHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LKFLAEVYLPQKIQTKDWIE
HHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA