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The map label for this gene is serS

Identifier: 156937780

GI number: 156937780

Start: 880379

End: 881755

Strand: Reverse

Name: serS

Synonym: Igni_0990

Alternate gene names: 156937780

Gene position: 881755-880379 (Counterclockwise)

Preceding gene: 156937781

Following gene: 156937779

Centisome position: 67.96

GC content: 55.12

Gene sequence:

>1377_bases
ATGCCGTGGAGCGTCTTGGAGGCGCTGAGGAACAACCCAGAGCTCCTAATAGAGTCCATGAAAAAGAGGTGCAAAGACCC
CCAACCCGTTTATGAAGCGATAAGGGTGGACGAGGAGTGGAGGAAGACCCTCCAAGAAGTGGAGAGGCTACGCCACGAAC
ACAACAAGATAACCCGCGAAGTCGCTAAGGCTAAGGACAAGGCCGAGAGGGAAGCACTAATAAAAAAGGCGAAAGAGCTA
TTGGCATTGAAGGAGGAGCTTGAGAAGAAGCTGAAGGAGTTAGAGGCCAAGAGGGAGGAGATCCTCCTCTCCTTGCCGAA
CCTCGTCCACCCCTCCGTCCCGGAGGGGTGCGACGAGGACCACAACGTGCCCGTCCGCTTCTGGGGGAAGCCGAAGGTCT
GGAAGGGTCACTTGGAGGAGTTCGAGAAGCAGACGAAGAGGTGGGGGTTCGAGGTAGAACACGAGGTAGTAGAGGAGAAG
CCCGTAGGCCACGCGGACATGCTGGAGAAGGTGCTGAGGCTCGGCAACACCTACAAGGCCGCCCAAGTGGCCTCCTCCCG
TTTCTACTACCTCTTCAAGGACCTCGTCTGGCTGGATTACGCACTAATGATGTACGCTATGGACTTCTTGAGCAAAAAGG
GCTTCGTGCTCGTGGAACCGCCCTACATGGTGAGGTACAAAGTGCTGAGGGGCGTGATAGACGTCGAGACCTTCAAGGAT
GCAATATACAAGATCGAGGGAGAAGACTTGTACTTGATCGCCACCTCTGAACACCCCCTAGCTGCCTACAAGATGGAAGA
GATAATAGACGAAAGCGAGTTGCCCATAAAGTTGGCCGGGGTGAGCCCTTGCTTTAGGAAGGAGGCGGGGGCCGGGAACA
GGGACTTAAAGGGTATATTCAGAGTTCACCAATTCCACAAAGTTGAGCAGTTCGTCTTCTCCAAGCCGGAGGACAGCTGG
GAGGTCTTAGAGGAACTGATAAGGAACGCGGAGGAGCTCGTCAAAGGGCTGGAGCTCCCCTACAGGGTGGTAAACGTCTG
CGGGGGCGAGCTCGGCAGCCCCGCAGCCAAGAAGTACGACTTGGAAGTTTGGTATCCTGCCCAAGGCAAGTATAGGGAGC
TCGTAAGCGCCTCCAACTGCACGGACTGGCAGAGCTACCGGTTGAAGATAAGGTACAGGATAAAGGGAGGGAAGAAACAC
GACTTCGTACACACTTTGAACTCCACCGCGCTCGCAACTACGAGGACAATAACGGCCATCTTAGAGAACCATCAACTGCC
GGACGGTCGCGTGAGGATTCCGAGGGCTTTGAGGAAGTACTTGGAACCCTTCGAAAGCGCGCCCAAAGACTACATAGAGC
CGTGGACCGGGATCTAA

Upstream 100 bases:

>100_bases
CGATGGGCGCGGGGCGGGTCACTCCCGGCCCAACCCCTTCTCCCCTCTTCAAACTTAGGCCCTATATTACGCCCCACGTA
AGGACGTCGGAGAGCCCGAA

Downstream 100 bases:

>100_bases
ACGAGCAAAGAATATTTAAACCCTTTAAAAATCCTTAAAAAGCGGGTCTCACTTTGTCTCTCGACGCTGAAGCGAAGCCC
AGTATAAAAATAGAAAACAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MPWSVLEALRNNPELLIESMKKRCKDPQPVYEAIRVDEEWRKTLQEVERLRHEHNKITREVAKAKDKAEREALIKKAKEL
LALKEELEKKLKELEAKREEILLSLPNLVHPSVPEGCDEDHNVPVRFWGKPKVWKGHLEEFEKQTKRWGFEVEHEVVEEK
PVGHADMLEKVLRLGNTYKAAQVASSRFYYLFKDLVWLDYALMMYAMDFLSKKGFVLVEPPYMVRYKVLRGVIDVETFKD
AIYKIEGEDLYLIATSEHPLAAYKMEEIIDESELPIKLAGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQFVFSKPEDSW
EVLEELIRNAEELVKGLELPYRVVNVCGGELGSPAAKKYDLEVWYPAQGKYRELVSASNCTDWQSYRLKIRYRIKGGKKH
DFVHTLNSTALATTRTITAILENHQLPDGRVRIPRALRKYLEPFESAPKDYIEPWTGI

Sequences:

>Translated_458_residues
MPWSVLEALRNNPELLIESMKKRCKDPQPVYEAIRVDEEWRKTLQEVERLRHEHNKITREVAKAKDKAEREALIKKAKEL
LALKEELEKKLKELEAKREEILLSLPNLVHPSVPEGCDEDHNVPVRFWGKPKVWKGHLEEFEKQTKRWGFEVEHEVVEEK
PVGHADMLEKVLRLGNTYKAAQVASSRFYYLFKDLVWLDYALMMYAMDFLSKKGFVLVEPPYMVRYKVLRGVIDVETFKD
AIYKIEGEDLYLIATSEHPLAAYKMEEIIDESELPIKLAGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQFVFSKPEDSW
EVLEELIRNAEELVKGLELPYRVVNVCGGELGSPAAKKYDLEVWYPAQGKYRELVSASNCTDWQSYRLKIRYRIKGGKKH
DFVHTLNSTALATTRTITAILENHQLPDGRVRIPRALRKYLEPFESAPKDYIEPWTGI
>Mature_457_residues
PWSVLEALRNNPELLIESMKKRCKDPQPVYEAIRVDEEWRKTLQEVERLRHEHNKITREVAKAKDKAEREALIKKAKELL
ALKEELEKKLKELEAKREEILLSLPNLVHPSVPEGCDEDHNVPVRFWGKPKVWKGHLEEFEKQTKRWGFEVEHEVVEEKP
VGHADMLEKVLRLGNTYKAAQVASSRFYYLFKDLVWLDYALMMYAMDFLSKKGFVLVEPPYMVRYKVLRGVIDVETFKDA
IYKIEGEDLYLIATSEHPLAAYKMEEIIDESELPIKLAGVSPCFRKEAGAGNRDLKGIFRVHQFHKVEQFVFSKPEDSWE
VLEELIRNAEELVKGLELPYRVVNVCGGELGSPAAKKYDLEVWYPAQGKYRELVSASNCTDWQSYRLKIRYRIKGGKKHD
FVHTLNSTALATTRTITAILENHQLPDGRVRIPRALRKYLEPFESAPKDYIEPWTGI

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=478, Percent_Identity=37.6569037656904, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI8923421, Length=424, Percent_Identity=32.5471698113208, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI225579074, Length=362, Percent_Identity=33.9779005524862, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1787120, Length=452, Percent_Identity=36.0619469026549, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17539260, Length=475, Percent_Identity=37.4736842105263, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17542084, Length=414, Percent_Identity=29.4685990338164, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=447, Percent_Identity=39.1498881431767, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6321799, Length=402, Percent_Identity=35.0746268656716, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24581334, Length=475, Percent_Identity=36, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI17737985, Length=386, Percent_Identity=31.0880829015544, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_IGNH4 (A8AB67)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435576.1
- ProteinModelPortal:   A8AB67
- SMR:   A8AB67
- STRING:   A8AB67
- GeneID:   5563082
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0990
- eggNOG:   arNOG04439
- HOGENOM:   HBG629391
- OMA:   VPIRFWG
- ProtClustDB:   PRK05431
- BioCyc:   IHOS453591:IGNI_0990-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 53350; Mature: 53219

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 302-302 BINDING 309-309 BINDING 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWSVLEALRNNPELLIESMKKRCKDPQPVYEAIRVDEEWRKTLQEVERLRHEHNKITRE
CCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VAKAKDKAEREALIKKAKELLALKEELEKKLKELEAKREEILLSLPNLVHPSVPEGCDED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
HNVPVRFWGKPKVWKGHLEEFEKQTKRWGFEVEHEVVEEKPVGHADMLEKVLRLGNTYKA
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
AQVASSRFYYLFKDLVWLDYALMMYAMDFLSKKGFVLVEPPYMVRYKVLRGVIDVETFKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
AIYKIEGEDLYLIATSEHPLAAYKMEEIIDESELPIKLAGVSPCFRKEAGAGNRDLKGIF
HHEEECCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCCCHHHHHH
RVHQFHKVEQFVFSKPEDSWEVLEELIRNAEELVKGLELPYRVVNVCGGELGSPAAKKYD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
LEVWYPAQGKYRELVSASNCTDWQSYRLKIRYRIKGGKKHDFVHTLNSTALATTRTITAI
EEEEECCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHH
LENHQLPDGRVRIPRALRKYLEPFESAPKDYIEPWTGI
HHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure 
PWSVLEALRNNPELLIESMKKRCKDPQPVYEAIRVDEEWRKTLQEVERLRHEHNKITRE
CHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VAKAKDKAEREALIKKAKELLALKEELEKKLKELEAKREEILLSLPNLVHPSVPEGCDED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCC
HNVPVRFWGKPKVWKGHLEEFEKQTKRWGFEVEHEVVEEKPVGHADMLEKVLRLGNTYKA
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCHHH
AQVASSRFYYLFKDLVWLDYALMMYAMDFLSKKGFVLVEPPYMVRYKVLRGVIDVETFKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
AIYKIEGEDLYLIATSEHPLAAYKMEEIIDESELPIKLAGVSPCFRKEAGAGNRDLKGIF
HHEEECCCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCCCCCHHHHHH
RVHQFHKVEQFVFSKPEDSWEVLEELIRNAEELVKGLELPYRVVNVCGGELGSPAAKKYD
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCC
LEVWYPAQGKYRELVSASNCTDWQSYRLKIRYRIKGGKKHDFVHTLNSTALATTRTITAI
EEEEECCCCHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHH
LENHQLPDGRVRIPRALRKYLEPFESAPKDYIEPWTGI
HHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA