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The map label for this gene is ahpC [C]

Identifier: 156937253

GI number: 156937253

Start: 404841

End: 405545

Strand: Direct

Name: ahpC [C]

Synonym: Igni_0459

Alternate gene names: 156937253

Gene position: 404841-405545 (Clockwise)

Preceding gene: 156937252

Following gene: 156937254

Centisome position: 31.2

GC content: 59.57

Gene sequence:

>705_bases
ATGCCGGGACAGATCCCCCTGATAGGCGAGAAGCTTCCGGAGATGGTGGTTCACACCGACCACGGCCCCAAGAAGCTCCC
CGACGACTACAAGGGTAAGTGGCTGGTGATCTTCAGCCACCCCGCCGACTTCACGCCGGTATGTACCACCGAGTTCGTAG
CGTTCGCGAAGAGGTACGAGGACTTCAAGAAGCTCAACACCGAGCTGCTGGGCCTCAGCGTGGACAACAGCTTCAGCCAC
ATCAAGTGGAAGGAGTGGATAAAGGAGAAGCTCAACGTCGAGATACCGTTCCCGATAATCGCCGACCCGCTGGGCCAAGT
GGCCACCAAGCTAGGGATGCTCCACCCCGAGGGCGGCGTAGTGACTGTAAGGGCGGTGTTCATAGTTGACCCCGAAGGGA
AGGTTAGGGCGATACTCTACTACCCGCTGAACGTCGGCAGGAACATAGACGAGATACTGAGGCTGCTGAAGGCGCTACAA
GTGACCGACAAGCTCGGAAGGGCCACCCCGGCCAACTGGCCGTGCAACGAGATAGTCAAGGACCACGTGATAGTTCCGCC
CGCATCCACCGAGCAGGAGGCGAAGGAGAGGTTGCAGAAGTACGAGTGCTTCGACTGGTGGTTCTGCCACGAGAAGGCCC
CCGCGGAGGACGTGGAGGAGGCCAAGAAGTTCCTCGAGAGGCCCGCCAAGGAGCTCTGCAAGTAA

Upstream 100 bases:

>100_bases
CGCCTCTCCGGGCCTTTTGAGGTCGGGGGCCTTAGGGCGTCGTAAGCCGAACATCCTGACTTTTTATGCAACCGTTCCCA
GAACCTCACGGAAGAGAGCC

Downstream 100 bases:

>100_bases
CTCCCGTTTTTTCTCACGTTTATCGTTTCCCTCCTATCCCGTTCGTTCAAGCGCGCTCCTCGATGAAGCCCCTTATCCCC
TCACCGAAGGTCCCCTTCGG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPGQIPLIGEKLPEMVVHTDHGPKKLPDDYKGKWLVIFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELLGLSVDNSFSH
IKWKEWIKEKLNVEIPFPIIADPLGQVATKLGMLHPEGGVVTVRAVFIVDPEGKVRAILYYPLNVGRNIDEILRLLKALQ
VTDKLGRATPANWPCNEIVKDHVIVPPASTEQEAKERLQKYECFDWWFCHEKAPAEDVEEAKKFLERPAKELCK

Sequences:

>Translated_234_residues
MPGQIPLIGEKLPEMVVHTDHGPKKLPDDYKGKWLVIFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELLGLSVDNSFSH
IKWKEWIKEKLNVEIPFPIIADPLGQVATKLGMLHPEGGVVTVRAVFIVDPEGKVRAILYYPLNVGRNIDEILRLLKALQ
VTDKLGRATPANWPCNEIVKDHVIVPPASTEQEAKERLQKYECFDWWFCHEKAPAEDVEEAKKFLERPAKELCK
>Mature_233_residues
PGQIPLIGEKLPEMVVHTDHGPKKLPDDYKGKWLVIFSHPADFTPVCTTEFVAFAKRYEDFKKLNTELLGLSVDNSFSHI
KWKEWIKEKLNVEIPFPIIADPLGQVATKLGMLHPEGGVVTVRAVFIVDPEGKVRAILYYPLNVGRNIDEILRLLKALQV
TDKLGRATPANWPCNEIVKDHVIVPPASTEQEAKERLQKYECFDWWFCHEKAPAEDVEEAKKFLERPAKELCK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4758638, Length=209, Percent_Identity=39.2344497607655, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4505591, Length=174, Percent_Identity=40.8045977011494, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI32455266, Length=174, Percent_Identity=40.8045977011494, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI32455264, Length=174, Percent_Identity=40.8045977011494, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI32189392, Length=161, Percent_Identity=42.8571428571429, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI5453549, Length=153, Percent_Identity=41.1764705882353, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI5802974, Length=147, Percent_Identity=38.7755102040816, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI32483377, Length=147, Percent_Identity=38.7755102040816, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=56.8965517241379, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786822, Length=150, Percent_Identity=34.6666666666667, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25153706, Length=202, Percent_Identity=36.1386138613861, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17554494, Length=146, Percent_Identity=41.7808219178082, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32565831, Length=175, Percent_Identity=38.2857142857143, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193204376, Length=154, Percent_Identity=40.9090909090909, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319407, Length=203, Percent_Identity=43.8423645320197, Blast_Score=155, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323613, Length=147, Percent_Identity=38.7755102040816, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320661, Length=145, Percent_Identity=35.1724137931034, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17975518, Length=203, Percent_Identity=42.8571428571429, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24652434, Length=203, Percent_Identity=42.8571428571429, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24652436, Length=203, Percent_Identity=42.8571428571429, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24581278, Length=180, Percent_Identity=41.6666666666667, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17738015, Length=151, Percent_Identity=41.0596026490066, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17157991, Length=146, Percent_Identity=41.7808219178082, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24641739, Length=146, Percent_Identity=41.7808219178082, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=36.3013698630137, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656348, Length=145, Percent_Identity=37.2413793103448, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17864676, Length=145, Percent_Identity=37.2413793103448, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH_IGNH4 (A8A9P0)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001435049.1
- ProteinModelPortal:   A8A9P0
- SMR:   A8A9P0
- STRING:   A8A9P0
- GeneID:   5561752
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0459
- eggNOG:   arNOG04373
- HOGENOM:   HBG493509
- OMA:   EVKTTHG
- ProtClustDB:   CLSK964488
- BioCyc:   IHOS453591:IGNI_0459-MONOMER
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 26711; Mature: 26580

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 48-48

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGQIPLIGEKLPEMVVHTDHGPKKLPDDYKGKWLVIFSHPADFTPVCTTEFVAFAKRYE
CCCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DFKKLNTELLGLSVDNSFSHIKWKEWIKEKLNVEIPFPIIADPLGQVATKLGMLHPEGGV
HHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHCCCCCCCCE
VTVRAVFIVDPEGKVRAILYYPLNVGRNIDEILRLLKALQVTDKLGRATPANWPCNEIVK
EEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DHVIVPPASTEQEAKERLQKYECFDWWFCHEKAPAEDVEEAKKFLERPAKELCK
CCEECCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PGQIPLIGEKLPEMVVHTDHGPKKLPDDYKGKWLVIFSHPADFTPVCTTEFVAFAKRYE
CCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DFKKLNTELLGLSVDNSFSHIKWKEWIKEKLNVEIPFPIIADPLGQVATKLGMLHPEGGV
HHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHCCCCCCCCE
VTVRAVFIVDPEGKVRAILYYPLNVGRNIDEILRLLKALQVTDKLGRATPANWPCNEIVK
EEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
DHVIVPPASTEQEAKERLQKYECFDWWFCHEKAPAEDVEEAKKFLERPAKELCK
CCEECCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA