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The map label for this gene is frdA [H]

Identifier: 156937071

GI number: 156937071

Start: 236728

End: 238413

Strand: Direct

Name: frdA [H]

Synonym: Igni_0276

Alternate gene names: 156937071

Gene position: 236728-238413 (Clockwise)

Preceding gene: 156937070

Following gene: 156937072

Centisome position: 18.24

GC content: 61.39

Gene sequence:

>1686_bases
TTGGAAACCCTCGGTCCCTATGACGTCGTCGTAGTTGGAGGGGGCCTGGCGGGCCTCAGGGCGGCGATCGAGGCGAGGCG
CCACGGGGCAAGCGCGCTGGTGGTCGCGAAGTCCCACCCGGTCCGGAGCCACTCCTCCGCCGCGGAGGGCGGGGTCGCCG
CTTACATCGAGGGCGCCTCCGACCCTAGGGACTCGCCCCTCCAGCACGCCTTCGACACCGTGAAGGGCTCGGACTGGCTG
GCCGACCAAGACGCGGTGGAGCTCATGGCCTTCGACGCCGAGAGGGCGATACTGGAGCTAGAGAAGTGGGGCTGCTTGTT
CTCCAGGGACCCCGACGGGAAGATCGCAAGGAGGCCCTTCGGGGGCCACACCTACCCCCGCACTAGGTTCGCCGCAGACA
AGACTGGTATGTGTATGCTCCATACGGTTTACGAAAGGGCCTTGGCTGAAGGCGTAGACATGCTTTACGAGTTCTACGTT
ACCGACGTCGTTAGTGACAAGAGGAAGGTTTACGGCGTTATAGGCTTTGACGTCAAGAGCGGGGACGTCTACTTCATCAA
GAGCAAGGCAGTGATACTCGCCACGGGCGGGGGCGGGTTGATGTACAAGTTCTCAACGAACAGTTATCTGAACTCGGGGG
ACGGCTACGCGATCGCCGCCAGGGCGGGCGCCCCCTTGGCGGACATGGAGTTCATCCAGTTCCACCCCACCGCCCTCTAC
CCCTCCAACATACTGATAACCGAGGCCGCCAGGGGCGAGGGAGGGTACCTTATCAACAAGAACGGAGAGAGGTTCATGAA
GAGGTACGCCCCCGAGAGGATGGAGCTCGCCCCGAGGGACGTGGTCGCGAGGGCGATAATGAACGAGATTAAAGAGGGGA
GGGGCTTCGAAGGGGGCTACGTGCTCCTCGACCTGACCCACCTAGGGGAGGAGAAGATAAACGAAAGGCTCCCCTTGGTT
AGGGAAGTGTCCATAAAGTTCGCCAAGGTGGATCCGGTTAAGGAGCCCATACCGGTAAGGCCGGCCGCGCACTACACCAT
GGGCGGGGTCAAGACCAACTTGGACGGCGCCACGGAGGTGAAGGGCTTGTTCGCGGCCGGCGAGGCCGCTTGCGTGAGCG
TTCACGGGGCCAACAGGTTGGGCAGCAACTCGTTGCTGGAGACCTTAGTGTTCGGCAGGAGGGCCGGTATGGCCGCTGCC
GCCTACGCGAAGGAGGTCGGCTACTCGGAGCCCCCGAAGGAGGCCTTGTCGGAGGCCGAGGCGAGGCTCTGGCTTCCCAC
TACCTCCGAGAGCGGCTTGAGCTTTGGTCAACTTAGGAAGGAGGTAGGCGAAATCATGTGGAATTACGTAGGCATAGAGA
GAAACGAAGAGGGCCTCAAGACGGCCGTCAAGAAGTTGAAAGAGCTAATGAACATGACCAAGTACGTGAAGGGCTCGGGA
GGCCCCGGCGCTTACGAGCTAGTCGCCGCTCACGAAACTATAAACATGGTAATGAACGCCTACGCGACCGCTACGGCCGC
CTTGTGGAGGACAGAGAGCAGGGGGGCGCACTACCGTTCCGACTACCCCAAGAGGGACAACGAGAACTGGCTCGCGCACA
CGATCATGCGCTGGAAGGGGACTTGGGAGATGGAGAAGCTGCCTGTAACGATAACTAGGTGGCCGCCCCAAGAGAGGAAG
TACTAA

Upstream 100 bases:

>100_bases
GGAGAGCGGGAGCTGCGAGACTTGTCCCCTCTACGGGAGCTGTCCCAAGGCGCAGTAAGGGTAAAAGCCCGAGCCCTCAA
GCTCCCCGGAGGAGGAAGTT

Downstream 100 bases:

>100_bases
CCTATTTCTCCCCTTAGTCCTAACCCTAGGAAGCGAAGAAATGTCCGAAGTAGCGATGGTCTACGACTTCAGCAGGAAGA
AATGCGGAATAAAGGAGTAC

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
METLGPYDVVVVGGGLAGLRAAIEARRHGASALVVAKSHPVRSHSSAAEGGVAAYIEGASDPRDSPLQHAFDTVKGSDWL
ADQDAVELMAFDAERAILELEKWGCLFSRDPDGKIARRPFGGHTYPRTRFAADKTGMCMLHTVYERALAEGVDMLYEFYV
TDVVSDKRKVYGVIGFDVKSGDVYFIKSKAVILATGGGGLMYKFSTNSYLNSGDGYAIAARAGAPLADMEFIQFHPTALY
PSNILITEAARGEGGYLINKNGERFMKRYAPERMELAPRDVVARAIMNEIKEGRGFEGGYVLLDLTHLGEEKINERLPLV
REVSIKFAKVDPVKEPIPVRPAAHYTMGGVKTNLDGATEVKGLFAAGEAACVSVHGANRLGSNSLLETLVFGRRAGMAAA
AYAKEVGYSEPPKEALSEAEARLWLPTTSESGLSFGQLRKEVGEIMWNYVGIERNEEGLKTAVKKLKELMNMTKYVKGSG
GPGAYELVAAHETINMVMNAYATATAALWRTESRGAHYRSDYPKRDNENWLAHTIMRWKGTWEMEKLPVTITRWPPQERK
Y

Sequences:

>Translated_561_residues
METLGPYDVVVVGGGLAGLRAAIEARRHGASALVVAKSHPVRSHSSAAEGGVAAYIEGASDPRDSPLQHAFDTVKGSDWL
ADQDAVELMAFDAERAILELEKWGCLFSRDPDGKIARRPFGGHTYPRTRFAADKTGMCMLHTVYERALAEGVDMLYEFYV
TDVVSDKRKVYGVIGFDVKSGDVYFIKSKAVILATGGGGLMYKFSTNSYLNSGDGYAIAARAGAPLADMEFIQFHPTALY
PSNILITEAARGEGGYLINKNGERFMKRYAPERMELAPRDVVARAIMNEIKEGRGFEGGYVLLDLTHLGEEKINERLPLV
REVSIKFAKVDPVKEPIPVRPAAHYTMGGVKTNLDGATEVKGLFAAGEAACVSVHGANRLGSNSLLETLVFGRRAGMAAA
AYAKEVGYSEPPKEALSEAEARLWLPTTSESGLSFGQLRKEVGEIMWNYVGIERNEEGLKTAVKKLKELMNMTKYVKGSG
GPGAYELVAAHETINMVMNAYATATAALWRTESRGAHYRSDYPKRDNENWLAHTIMRWKGTWEMEKLPVTITRWPPQERK
Y
>Mature_561_residues
METLGPYDVVVVGGGLAGLRAAIEARRHGASALVVAKSHPVRSHSSAAEGGVAAYIEGASDPRDSPLQHAFDTVKGSDWL
ADQDAVELMAFDAERAILELEKWGCLFSRDPDGKIARRPFGGHTYPRTRFAADKTGMCMLHTVYERALAEGVDMLYEFYV
TDVVSDKRKVYGVIGFDVKSGDVYFIKSKAVILATGGGGLMYKFSTNSYLNSGDGYAIAARAGAPLADMEFIQFHPTALY
PSNILITEAARGEGGYLINKNGERFMKRYAPERMELAPRDVVARAIMNEIKEGRGFEGGYVLLDLTHLGEEKINERLPLV
REVSIKFAKVDPVKEPIPVRPAAHYTMGGVKTNLDGATEVKGLFAAGEAACVSVHGANRLGSNSLLETLVFGRRAGMAAA
AYAKEVGYSEPPKEALSEAEARLWLPTTSESGLSFGQLRKEVGEIMWNYVGIERNEEGLKTAVKKLKELMNMTKYVKGSG
GPGAYELVAAHETINMVMNAYATATAALWRTESRGAHYRSDYPKRDNENWLAHTIMRWKGTWEMEKLPVTITRWPPQERK
Y

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=523, Percent_Identity=40.7265774378585, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1786942, Length=558, Percent_Identity=42.2939068100358, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1790597, Length=554, Percent_Identity=42.057761732852, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=549, Percent_Identity=36.0655737704918, Blast_Score=264, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17505833, Length=586, Percent_Identity=40.7849829351536, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17550100, Length=584, Percent_Identity=40.0684931506849, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71986328, Length=271, Percent_Identity=30.6273062730627, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322701, Length=570, Percent_Identity=40.8771929824561, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=41.5492957746479, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320788, Length=486, Percent_Identity=28.6008230452675, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=476, Percent_Identity=26.0504201680672, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=41.4678899082569, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=41.4678899082569, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=41.4678899082569, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24663005, Length=609, Percent_Identity=36.2889983579639, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 61581; Mature: 61581

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLGPYDVVVVGGGLAGLRAAIEARRHGASALVVAKSHPVRSHSSAAEGGVAAYIEGAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCC
DPRDSPLQHAFDTVKGSDWLADQDAVELMAFDAERAILELEKWGCLFSRDPDGKIARRPF
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEECCCC
GGHTYPRTRFAADKTGMCMLHTVYERALAEGVDMLYEFYVTDVVSDKRKVYGVIGFDVKS
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECC
GDVYFIKSKAVILATGGGGLMYKFSTNSYLNSGDGYAIAARAGAPLADMEFIQFHPTALY
CCEEEEECCEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEEC
PSNILITEAARGEGGYLINKNGERFMKRYAPERMELAPRDVVARAIMNEIKEGRGFEGGY
CCCEEEEECCCCCCCEEECCCHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCE
VLLDLTHLGEEKINERLPLVREVSIKFAKVDPVKEPIPVRPAAHYTMGGVKTNLDGATEV
EEEEEHHCCHHHHHHHCCCEECCEEEEEECCCCCCCCCCCCCCCEEECCEEECCCCCHHH
KGLFAAGEAACVSVHGANRLGSNSLLETLVFGRRAGMAAAAYAKEVGYSEPPKEALSEAE
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHCC
ARLWLPTTSESGLSFGQLRKEVGEIMWNYVGIERNEEGLKTAVKKLKELMNMTKYVKGSG
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GPGAYELVAAHETINMVMNAYATATAALWRTESRGAHYRSDYPKRDNENWLAHTIMRWKG
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
TWEMEKLPVTITRWPPQERKY
CCEEEECCEEEEECCCCCCCC
>Mature Secondary Structure
METLGPYDVVVVGGGLAGLRAAIEARRHGASALVVAKSHPVRSHSSAAEGGVAAYIEGAS
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCC
DPRDSPLQHAFDTVKGSDWLADQDAVELMAFDAERAILELEKWGCLFSRDPDGKIARRPF
CCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEECCCC
GGHTYPRTRFAADKTGMCMLHTVYERALAEGVDMLYEFYVTDVVSDKRKVYGVIGFDVKS
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECC
GDVYFIKSKAVILATGGGGLMYKFSTNSYLNSGDGYAIAARAGAPLADMEFIQFHPTALY
CCEEEEECCEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEEC
PSNILITEAARGEGGYLINKNGERFMKRYAPERMELAPRDVVARAIMNEIKEGRGFEGGY
CCCEEEEECCCCCCCEEECCCHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCE
VLLDLTHLGEEKINERLPLVREVSIKFAKVDPVKEPIPVRPAAHYTMGGVKTNLDGATEV
EEEEEHHCCHHHHHHHCCCEECCEEEEEECCCCCCCCCCCCCCCEEECCEEECCCCCHHH
KGLFAAGEAACVSVHGANRLGSNSLLETLVFGRRAGMAAAAYAKEVGYSEPPKEALSEAE
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHCC
ARLWLPTTSESGLSFGQLRKEVGEIMWNYVGIERNEEGLKTAVKKLKELMNMTKYVKGSG
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GPGAYELVAAHETINMVMNAYATATAALWRTESRGAHYRSDYPKRDNENWLAHTIMRWKG
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
TWEMEKLPVTITRWPPQERKY
CCEEEECCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]