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The map label for this gene is ogt [H]

Identifier: 156936998

GI number: 156936998

Start: 181026

End: 181334

Strand: Direct

Name: ogt [H]

Synonym: Igni_0203

Alternate gene names: 156936998

Gene position: 181026-181334 (Clockwise)

Preceding gene: 156936996

Following gene: 156937000

Centisome position: 13.95

GC content: 55.99

Gene sequence:

>309_bases
TTGTTGAGAAGGCTGGAGCTTCTGAAAGAATTGCTGCTCTTAATACCGTTAGGGAAGGTGACCACGTACTCTTCGTTGGC
CTCTTTGTTGGGTACCCACCCCAGGGCGGTGGGCGCGATGCTCGCGCGAAACGAGGACTTGGTGGTTTACCCTTGCCACC
GCGTAGTTATGTCAGACGGTAGGCTGGGGGGTTACGCCTTGGGTAAGGAGTTCAAGAGGAGGCTGTTAGAGCTCGAAGGG
GTGAAGTTCTGCGGTCCCGAGAGGGTGTGTAAGGAGAGCGTGGTCGACCTCAAAGAGCTGCTCTCTTAG

Upstream 100 bases:

>100_bases
AAGGGACACCTCTCCCCGATCTGACCTTGGCCGTCGAGGGGCCTCCTCCAATATATAACCAACTCTCGAGTCCCACCCAA
GACGGCCCTTAGGGGTAAAA

Downstream 100 bases:

>100_bases
ATAGCAACCCACGGATCAAGAGCAAAGCGGTGGGCGCGACCCATGGAGGAACGCTTAAACCTCTCGTACCTTCATTATCT
TCCTTCATCAAGGTTATTGG

Product: methylated-DNA--protein-cysteine methyltransferase

Products: NA

Alternate protein names: 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase [H]

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MLRRLELLKELLLLIPLGKVTTYSSLASLLGTHPRAVGAMLARNEDLVVYPCHRVVMSDGRLGGYALGKEFKRRLLELEG
VKFCGPERVCKESVVDLKELLS

Sequences:

>Translated_102_residues
MLRRLELLKELLLLIPLGKVTTYSSLASLLGTHPRAVGAMLARNEDLVVYPCHRVVMSDGRLGGYALGKEFKRRLLELEG
VKFCGPERVCKESVVDLKELLS
>Mature_102_residues
MLRRLELLKELLLLIPLGKVTTYSSLASLLGTHPRAVGAMLARNEDLVVYPCHRVVMSDGRLGGYALGKEFKRRLLELEG
VKFCGPERVCKESVVDLKELLS

Specific function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a sui

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MGMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01035 DNA_binding_1 [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 11381; Mature: 11381

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRLELLKELLLLIPLGKVTTYSSLASLLGTHPRAVGAMLARNEDLVVYPCHRVVMSDG
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHCCC
RLGGYALGKEFKRRLLELEGVKFCGPERVCKESVVDLKELLS
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLRRLELLKELLLLIPLGKVTTYSSLASLLGTHPRAVGAMLARNEDLVVYPCHRVVMSDG
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECHHHHHHCCC
RLGGYALGKEFKRRLLELEGVKFCGPERVCKESVVDLKELLS
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA