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The map label for this gene is hisE

Identifier: 156936824

GI number: 156936824

Start: 28586

End: 28894

Strand: Direct

Name: hisE

Synonym: Igni_0029

Alternate gene names: 156936824

Gene position: 28586-28894 (Clockwise)

Preceding gene: 156936821

Following gene: 156936825

Centisome position: 2.2

GC content: 52.43

Gene sequence:

>309_bases
GTGAGCGACTTCCTGTCCGAATTGTGGCTCGTAATAAAGAAAAGGATAGAAGAAAAACCTCAGGGTTCCTACACAGCCGA
GATTGTGAAGAGAGGTCTACCCTTCGCTGCTAGGAAGTTCGGCGAAGAGAGCGTAGAACTCATCGTCGCCTCTCTCTCGG
AGCCTCGGGATTCCGTAATCTACGAGGCCGCTGACGTAATCTACCACTTGATGGTGTTGTTAGCCTTGAGAGGGGTGGAC
TGGGCTGAGGTTATCAAGGAGCTAGAGAGGAGGTCAAGGGCGAAGAGCGGTGCTGGCGGCAATAGTTAA

Upstream 100 bases:

>100_bases
AGTTAATGTAAGCTTTTCCGCGTAGCAACGGAGTGATACGGGCCACCACCTCAGCGGTTGAATAAGGACCTTTTATCTCC
GTGCTCGCGGGAGGTCTGAC

Downstream 100 bases:

>100_bases
CTACGGAATAGGGAACTTATTTAGCGTTAAGAAAGGTTTCGAGAGGGCGGGCTTCAGAGTTGTAGTATCTAACGACAAAG
AGGTCTTGAAGGGAAGCGAC

Product: phosphoribosyl-ATP pyrophosphohydrolase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 102; Mature: 101

Protein sequence:

>102_residues
MSDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEAADVIYHLMVLLALRGVD
WAEVIKELERRSRAKSGAGGNS

Sequences:

>Translated_102_residues
MSDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEAADVIYHLMVLLALRGVD
WAEVIKELERRSRAKSGAGGNS
>Mature_101_residues
SDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEAADVIYHLMVLLALRGVDW
AEVIKELERRSRAKSGAGGNS

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=37.7777777777778, Blast_Score=64, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_IGNH4 (A8A8G1)

Other databases:

- EMBL:   CP000816
- RefSeq:   YP_001434620.1
- ProteinModelPortal:   A8A8G1
- SMR:   A8A8G1
- STRING:   A8A8G1
- GeneID:   5562976
- GenomeReviews:   CP000816_GR
- KEGG:   iho:Igni_0029
- eggNOG:   arNOG13425
- HOGENOM:   HBG646527
- OMA:   VCKELER
- BioCyc:   IHOS453591:IGNI_0029-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11422; Mature: 11291

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVI
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
YEAADVIYHLMVLLALRGVDWAEVIKELERRSRAKSGAGGNS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
YEAADVIYHLMVLLALRGVDWAEVIKELERRSRAKSGAGGNS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA