Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679860

GI number: 15679860

Start: 1707165

End: 1708100

Strand: Direct

Name: Not Available

Synonym: MTH1872

Alternate gene names: NA

Gene position: 1707165-1708100 (Clockwise)

Preceding gene: 15679859

Following gene: 15679862

Centisome position: 97.48

GC content: 52.24

Gene sequence:

>936_bases
ATGAACATGAAGACCATTGAATGGAAGGATGGAGAGCTGGTCCTCATCGACCAGCGCAAGCTACCTGACTCCCTCGAGTA
CTTCCGCTGCAGGGACTACAGGGACGTTATATATGCCATAAAGAACATGGTTGTCAGGGGTGCACCGGCAATAGGGGTTA
CAGCAGCATTCGGGGTTGCAATGGCGGAACTCGCCGGTGAGGATGTTGAGGTGGCAGCAGAGGAAATAAAGGCATCTAGA
CCAACAGCAGTGAACCTGTTCTGGGCCGTTGACCGTGTGATGAAATCAGAATCTCCCCTGGATGAGGCCATCACAATGTA
CATGGAGGACATGGAGACCAACAGGGCAATAGGAAGACACGGCGCTGGGCTCATAGAGGATGGTGACACGGTTTTAACCC
ACTGCAATGCAGGGGCCCTTGCCTGCGTTGACTACGGAACAGCCCTTGGGGTTATAAGGGCCGCATGGGATGATGGGAAA
AGGTTAACAGTCATATGTGATGAAACAAGGCCAGTCGGCCAGGGTGCAAGGCTCAGTGTCTGGGAGATGCAGCAGGAGGG
CATACCCGTTAAGCTGATAACGGATGTTGCAGCAGGCTACCTGATGCAGACTGGCATGATCGATAAGGTGATAATAGGCG
CCGACCGTATCGCAGAGGGGGGCGTGGCAAATAAGATAGGCTCCCTCATGGTTGCCCTGGCAGCAAAACGTTTCAATGTC
CCCTTCTATGTTGCAGCACCCATGAGCACATTTGACACGGAAAACTCCATCTATGACATCGAAATCGAGGAGCGGGATCC
TGCAGAGGTTCTATATTATGGTGGATGCAGGATAGCGCCGCAGGATACAGAGGCCATTAACCCTGCATTTGATATCGTAC
CATCGGACCTCATATCAGGTATTATAACTGAGAAGGGTATCCTTGACCCCCTCTAG

Upstream 100 bases:

>100_bases
TGTACACAGTGCAGGGCAGACGCCTACGGAATCCCCGGGAAGAAAGAAGCTGATAAACACCTTGACATGACACCAGCAAG
CCACTACTGACCATGGATAG

Downstream 100 bases:

>100_bases
ACTCTGAAATCATAGAATAAACCCCTTTTTTATATCAGGGAGTTATACCCTTTTCATTTTTTTCTGTATCTGAAGAGGGA
GTTTTCCTTATTCTTGCGTC

Product: translation initiation factor eIF-2B, alpha subunit

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVAMAELAGEDVEVAAEEIKASR
PTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRHGAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGK
RLTVICDETRPVGQGARLSVWEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNV
PFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISGIITEKGILDPL

Sequences:

>Translated_311_residues
MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVAMAELAGEDVEVAAEEIKASR
PTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRHGAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGK
RLTVICDETRPVGQGARLSVWEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNV
PFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISGIITEKGILDPL
>Mature_311_residues
MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVAMAELAGEDVEVAAEEIKASR
PTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRHGAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGK
RLTVICDETRPVGQGARLSVWEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNV
PFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISGIITEKGILDPL

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=347, Percent_Identity=38.328530259366, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI23943880, Length=331, Percent_Identity=33.5347432024169, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4503503, Length=192, Percent_Identity=30.7291666666667, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI78000156, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI78000158, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI187607323, Length=229, Percent_Identity=26.2008733624454, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=33.3333333333333, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17557123, Length=181, Percent_Identity=28.7292817679558, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=379, Percent_Identity=34.3007915567282, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322878, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357667, Length=352, Percent_Identity=38.9204545454545, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24651647, Length=352, Percent_Identity=38.9204545454545, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21358605, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_METTH (O27900)

Other databases:

- EMBL:   AE000666
- PIR:   E69117
- RefSeq:   NP_276978.1
- ProteinModelPortal:   O27900
- SMR:   O27900
- STRING:   O27900
- GeneID:   1470957
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1872
- NMPDR:   fig|187420.1.peg.1833
- eggNOG:   arNOG04953
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   O27900
- ProtClustDB:   CLSK798295
- BioCyc:   MTHE187420:MTH1872-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 33872; Mature: 33872

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: ACT_SITE 215-215 BINDING 80-80 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVA
CCCCEEEECCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MAELAGEDVEVAAEEIKASRPTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRH
HHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGKRLTVICDETRPVGQGARLSV
CCCEEECCCEEEEECCCCEEEEEHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCEEEE
WEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNV
EEHHHCCCCEEEHHHHHHHHHHHCCCHHHEEECCHHHCCCCHHHHHHHHHHHHHHHHCCC
PFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISG
CEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCEEECCCCCCCCCCHHHCCCHHHHHH
IITEKGILDPL
HHHCCCCCCCC
>Mature Secondary Structure
MNMKTIEWKDGELVLIDQRKLPDSLEYFRCRDYRDVIYAIKNMVVRGAPAIGVTAAFGVA
CCCCEEEECCCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
MAELAGEDVEVAAEEIKASRPTAVNLFWAVDRVMKSESPLDEAITMYMEDMETNRAIGRH
HHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GAGLIEDGDTVLTHCNAGALACVDYGTALGVIRAAWDDGKRLTVICDETRPVGQGARLSV
CCCEEECCCEEEEECCCCEEEEEHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCEEEE
WEMQQEGIPVKLITDVAAGYLMQTGMIDKVIIGADRIAEGGVANKIGSLMVALAAKRFNV
EEHHHCCCCEEEHHHHHHHHHHHCCCHHHEEECCHHHCCCCHHHHHHHHHHHHHHHHCCC
PFYVAAPMSTFDTENSIYDIEIEERDPAEVLYYGGCRIAPQDTEAINPAFDIVPSDLISG
CEEEECCCCCCCCCCCEEEEEECCCCCCEEEEECCEEECCCCCCCCCCHHHCCCHHHHHH
IITEKGILDPL
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463