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Identifier: 15679691

GI number: 15679691

Start: 1554114

End: 1554452

Strand: Direct

Name: Not Available

Synonym: MTH1697

Alternate gene names: 15679691

Gene position: 1554114-1554452 (Clockwise)

Preceding gene: 15679688

Following gene: 15679692

Centisome position: 88.74

GC content: 45.13

Gene sequence:

>339_bases
ATGAAACAGGTCATAATAGTGAGATCCGATCTGAAGATGGGGAAGGGTAAAATAGCAGCCCAGGCCTGTCATGCTTCCAT
AGGATCATTTAAAAGGACTGAAGAGGATAAAATAAGAAAATGGGAACTTGAAGGCTCAAAGAAGGTCATTGTTTCTGTGA
ATAGTCTTGATGAACTGCTTGAGATATACAGGGCTGTTAAGGAGGCGGGAATCTCAAACTACCTGGTGAGGGATGCGGGA
CACACCCAGATACCAGCCGGCACCATAACCTGCCTTGGGATAGGCCCCGATGACGATGAGAAGATAGATAAAATAACAGG
TGATCTGAAGCTGCTTTAG

Upstream 100 bases:

>100_bases
ATGGTTAACATGTGCATCAGATGGTTGCTGGTAGCTTCCCGTTTCCTCAGCTTGGAAATCATTATTAGCGGTAAGGAAGA
TAGAACCCAGTGGTGGGAAA

Downstream 100 bases:

>100_bases
CTGTGAGGTCCTTCCAGCAGATTAATCAGGTGTTTACCATGGAGTGGGTTGTTAAGATAGGTGGAAGCCTTTTTCCAGAA
CATGCCGCAGCCCTCCTTGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEDKIRKWELEGSKKVIVSVNSLDELLEIYRAVKEAGISNYLVRDAG
HTQIPAGTITCLGIGPDDDEKIDKITGDLKLL

Sequences:

>Translated_112_residues
MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEDKIRKWELEGSKKVIVSVNSLDELLEIYRAVKEAGISNYLVRDAG
HTQIPAGTITCLGIGPDDDEKIDKITGDLKLL
>Mature_112_residues
MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEDKIRKWELEGSKKVIVSVNSLDELLEIYRAVKEAGISNYLVRDAG
HTQIPAGTITCLGIGPDDDEKIDKITGDLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family

Homologues:

Organism=Homo sapiens, GI7706351, Length=113, Percent_Identity=43.3628318584071, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558188, Length=116, Percent_Identity=42.2413793103448, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319414, Length=120, Percent_Identity=35.8333333333333, Blast_Score=85, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281376919, Length=115, Percent_Identity=44.3478260869565, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24644665, Length=115, Percent_Identity=44.3478260869565, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=37.6068376068376, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_METTH (O27732)

Other databases:

- EMBL:   AE000666
- PIR:   H69093
- RefSeq:   NP_276808.1
- ProteinModelPortal:   O27732
- SMR:   O27732
- STRING:   O27732
- GeneID:   1470782
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1697
- NMPDR:   fig|187420.1.peg.1663
- eggNOG:   arNOG11345
- HOGENOM:   HBG526257
- OMA:   IQRRNPE
- PhylomeDB:   O27732
- ProtClustDB:   PRK04322
- BioCyc:   MTHE187420:MTH1697-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00628
- InterPro:   IPR002833
- TIGRFAMs:   TIGR00283

Pfam domain/function: PF01981 PTH2

EC number: =3.1.1.29

Molecular weight: Translated: 12294; Mature: 12294

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEDKIRKWELEGSKKVIVSVNSLDELL
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCEEEEEECCHHHHH
EIYRAVKEAGISNYLVRDAGHTQIPAGTITCLGIGPDDDEKIDKITGDLKLL
HHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHCCCEECC
>Mature Secondary Structure
MKQVIIVRSDLKMGKGKIAAQACHASIGSFKRTEEDKIRKWELEGSKKVIVSVNSLDELL
CCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCEEEEEECCHHHHH
EIYRAVKEAGISNYLVRDAGHTQIPAGTITCLGIGPDDDEKIDKITGDLKLL
HHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463