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Identifier: 15679599

GI number: 15679599

Start: 1470981

End: 1471730

Strand: Direct

Name: Not Available

Synonym: MTH1604

Alternate gene names: 15679599

Gene position: 1470981-1471730 (Clockwise)

Preceding gene: 15679598

Following gene: 15679601

Centisome position: 83.99

GC content: 54.53

Gene sequence:

>750_bases
ATGTGGTACTACCGGACCGTTGGTGGTGGCAGATGCCCCATCATGGATACCTGGTGGCAGACAGAGACCGGGATGCACAT
AATAACACCCCTCCCTGTGACACCCCTGAAGCCGGGTTCCGCAGGAAAACCATTCCCCACGGTGATAGCCGACGTTGTGG
ATGATGAGGGGAGGAGTCTGCGTGGAAGCGGAGGCCACCTTGTGATAAAAACACCGTGGCCTGCAATGTTCAGGACACTC
TTCAGGGAGCCTGAGAGGTATGTGGATGCCTACTGGAGCACATTTCCGGGCATCTACCTCAGCGGTGATGTTGCAAGGAT
AGATGAGGATGGTTACTTCTGGATCCAGGGCAGGGAGGACGATGTCCTCAACGTTGCAGGGCACAGGATAAGCACTGCAG
AGGTTGAATCAGCCCTTGTGAGCCATCCTGATGTTGTTGAGGCTGCGGTGGTTGGAAAACCTGACATCCTCAGGGGAGAG
GAGATAGCGGCCTTCGTTACTCTGAGGGATAAAGTGGAGCCCACACCCCGCCTCAAGGGTGTTCTGCGTGAACATGTGCG
GAGGGAGATAGGTCCCATTGCAAGTCCCAGTTACATAGAGTTCGTTGAGGACCTTCCAAAGACAAGGTCAGGTAAGATAA
TGAGGAGGGTGATAAAGGCCATTGTGAGGGGTGAGGATGTGGGTGATGTCAGCACCCTCTCAAACCCGGAATCAGTGAGT
ATGCTGGAGGACAGGGTCCGTACATTCTGA

Upstream 100 bases:

>100_bases
GGCTCTTCATGAAATATGGGGACAAGTGGCCTGAGAAGTATGACCTCAGAACACTCAGAATACTGGGGTCCGTTGGGAAC
CCATAAACCCCGAGGCCTGG

Downstream 100 bases:

>100_bases
TGATGTCATCAGACAATTCTTTTTTATCGGAGAATCAGTACTGGTTTTCATGCCAGGCATACCGTTGCCAGTATGCCATT
TGCCGATGGGAGAATCAGTT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MWYYRTVGGGRCPIMDTWWQTETGMHIITPLPVTPLKPGSAGKPFPTVIADVVDDEGRSLRGSGGHLVIKTPWPAMFRTL
FREPERYVDAYWSTFPGIYLSGDVARIDEDGYFWIQGREDDVLNVAGHRISTAEVESALVSHPDVVEAAVVGKPDILRGE
EIAAFVTLRDKVEPTPRLKGVLREHVRREIGPIASPSYIEFVEDLPKTRSGKIMRRVIKAIVRGEDVGDVSTLSNPESVS
MLEDRVRTF

Sequences:

>Translated_249_residues
MWYYRTVGGGRCPIMDTWWQTETGMHIITPLPVTPLKPGSAGKPFPTVIADVVDDEGRSLRGSGGHLVIKTPWPAMFRTL
FREPERYVDAYWSTFPGIYLSGDVARIDEDGYFWIQGREDDVLNVAGHRISTAEVESALVSHPDVVEAAVVGKPDILRGE
EIAAFVTLRDKVEPTPRLKGVLREHVRREIGPIASPSYIEFVEDLPKTRSGKIMRRVIKAIVRGEDVGDVSTLSNPESVS
MLEDRVRTF
>Mature_249_residues
MWYYRTVGGGRCPIMDTWWQTETGMHIITPLPVTPLKPGSAGKPFPTVIADVVDDEGRSLRGSGGHLVIKTPWPAMFRTL
FREPERYVDAYWSTFPGIYLSGDVARIDEDGYFWIQGREDDVLNVAGHRISTAEVESALVSHPDVVEAAVVGKPDILRGE
EIAAFVTLRDKVEPTPRLKGVLREHVRREIGPIASPSYIEFVEDLPKTRSGKIMRRVIKAIVRGEDVGDVSTLSNPESVS
MLEDRVRTF

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI253970489, Length=245, Percent_Identity=51.8367346938776, Blast_Score=248, Evalue=3e-66,
Organism=Homo sapiens, GI8923896, Length=245, Percent_Identity=51.8367346938776, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI28416953, Length=246, Percent_Identity=41.0569105691057, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI13375727, Length=247, Percent_Identity=39.6761133603239, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI38505220, Length=208, Percent_Identity=39.4230769230769, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI122937307, Length=207, Percent_Identity=40.0966183574879, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI115511026, Length=219, Percent_Identity=37.4429223744292, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI42544132, Length=212, Percent_Identity=36.7924528301887, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI58082049, Length=213, Percent_Identity=36.150234741784, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI157311624, Length=207, Percent_Identity=37.1980676328502, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI157311622, Length=207, Percent_Identity=37.1980676328502, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI187761345, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI187761343, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI31982927, Length=194, Percent_Identity=28.3505154639175, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI156151445, Length=187, Percent_Identity=32.0855614973262, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI195947378, Length=121, Percent_Identity=38.8429752066116, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790505, Length=249, Percent_Identity=53.4136546184739, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI1786529, Length=243, Percent_Identity=38.2716049382716, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786810, Length=169, Percent_Identity=33.1360946745562, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788107, Length=237, Percent_Identity=29.535864978903, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693145, Length=146, Percent_Identity=35.6164383561644, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI221142682, Length=208, Percent_Identity=28.8461538461538, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=246, Percent_Identity=45.9349593495935, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71982997, Length=246, Percent_Identity=45.9349593495935, Blast_Score=201, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17569507, Length=217, Percent_Identity=29.9539170506912, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=207, Percent_Identity=27.0531400966184, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=124, Percent_Identity=33.0645161290323, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=172, Percent_Identity=29.0697674418605, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=188, Percent_Identity=27.6595744680851, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=206, Percent_Identity=25.7281553398058, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71985884, Length=209, Percent_Identity=28.7081339712919, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319264, Length=260, Percent_Identity=48.8461538461538, Blast_Score=235, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6323182, Length=256, Percent_Identity=46.875, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319699, Length=218, Percent_Identity=26.605504587156, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI62472339, Length=245, Percent_Identity=51.0204081632653, Blast_Score=243, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24667955, Length=245, Percent_Identity=51.0204081632653, Blast_Score=243, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24667959, Length=245, Percent_Identity=51.0204081632653, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI21355225, Length=224, Percent_Identity=33.4821428571429, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI18859661, Length=179, Percent_Identity=33.5195530726257, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581924, Length=207, Percent_Identity=29.4685990338164, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648260, Length=204, Percent_Identity=28.921568627451, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355181, Length=200, Percent_Identity=28.5, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356947, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648257, Length=193, Percent_Identity=29.5336787564767, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 27832; Mature: 27832

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWYYRTVGGGRCPIMDTWWQTETGMHIITPLPVTPLKPGSAGKPFPTVIADVVDDEGRSL
CEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
RGSGGHLVIKTPWPAMFRTLFREPERYVDAYWSTFPGIYLSGDVARIDEDGYFWIQGRED
CCCCCEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCEEEECCEEEECCCCEEEEECCCC
DVLNVAGHRISTAEVESALVSHPDVVEAAVVGKPDILRGEEIAAFVTLRDKVEPTPRLKG
CEEECCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHH
VLREHVRREIGPIASPSYIEFVEDLPKTRSGKIMRRVIKAIVRGEDVGDVSTLSNPESVS
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
MLEDRVRTF
HHHHHHHCC
>Mature Secondary Structure
MWYYRTVGGGRCPIMDTWWQTETGMHIITPLPVTPLKPGSAGKPFPTVIADVVDDEGRSL
CEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
RGSGGHLVIKTPWPAMFRTLFREPERYVDAYWSTFPGIYLSGDVARIDEDGYFWIQGRED
CCCCCEEEEECCCHHHHHHHHHCHHHHHHHHHHHCCCEEEECCEEEECCCCEEEEECCCC
DVLNVAGHRISTAEVESALVSHPDVVEAAVVGKPDILRGEEIAAFVTLRDKVEPTPRLKG
CEEECCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHH
VLREHVRREIGPIASPSYIEFVEDLPKTRSGKIMRRVIKAIVRGEDVGDVSTLSNPESVS
HHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
MLEDRVRTF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]