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Identifier: 15679598

GI number: 15679598

Start: 1469764

End: 1470966

Strand: Direct

Name: Not Available

Synonym: MTH1603

Alternate gene names: 15679598

Gene position: 1469764-1470966 (Clockwise)

Preceding gene: 15679596

Following gene: 15679599

Centisome position: 83.92

GC content: 54.28

Gene sequence:

>1203_bases
TTGTTTATGAGAGGACAGCTTGATGCTCTGCTCAGGGAGGAAAGGGTTTTTAATCCAGACGAGGAACTTGCAGAAAACAG
CAATATAAGGGCCTGGATGGACGCCCGGGGTATTGGGGGTTATGATGAGCTCCTTGAGAGGGCCAGCTCTGACCCTGAGT
GGTTCTGGGATGAGATGGCATCTGAACTCGAATGGTTCAGACCCTACACCAGGGTCCTTGAATGGGAACCACCCCATGCC
CGCTGGTTCACAGGCGGGAAATTCAACATCACATACAGTGCCCTTGACAGGCATGTTATGGGTCCTGAGAGAAACAGGGT
GGCATATATATGGGAGGGTGAGGATGGTAGCGTCCGGAAGCTCACCTACTATGACCTCTACAGGGAGGTTAACCGCCTGG
CCAATGCCCTTAAGGATATGGGTGTCTCAAGGGGGGACCGCGTCAGCATATACCTCCCCATGATACCGGAACTCCCCATA
GCCATGCTCGCCTGTGCACGTATAGGTGCAGTCCACAGTGTAGTGTTCAGCGGCTTCTGGGCCAAGGCCTTCAGGGAGAG
GGCTGCAGATGCCGGGGCAAAGGTTGCGATCACTGCAGACGCATTCTACCGCAGGGGTAAGGTAATAAGACTCAAGGAAA
CCCTTGATATGGTCGCAGATGAGATCCCCTCCCTTGAGAGGGTCATAGTCGTGAACCGCATGGGGGATGATGTCAGCATG
GTGGATGGGAGGGATATCTACTGGAGCGAGGCTGTTGAGGGCATGGACGATGAATGTCCCTGCCAGGAGCTTGACCCTGA
GGATCCCCTCTTCATACTCTACACCTCTGGCACGACGGGTAAACCAAAGGGTGTTGTGCACACCCATGGGGGCTACGCCG
TGGGTGTGAGCTCTACCTACAGGTTCGTCTTCGATGTTAAGGACCAGGACATATGGTGGTGTCTGGCTGACATAGGATGG
ATAACGGGTCACAGCTACATAGTCTACGCCCCCCTCATTGAGGGTGCAACCTCGGTCATCTATGAGGGTGCACCTGATCA
CCCGGATCCTGGAAGGATATGGAGCATGGTTGAGAGGTACGGTGTCAGCATCCTCTACACAGCACCCACGACGGTGAGGC
TCTTCATGAAATATGGGGACAAGTGGCCTGAGAAGTATGACCTCAGAACACTCAGAATACTGGGGTCCGTTGGGAACCCA
TAA

Upstream 100 bases:

>100_bases
CCAGGATCCCTGCAAGGACCTCCGCACACATCTTCATGCACCCATCTATATTCTGCCAACTATTTAAATCATGAATTAAA
AAAATATTAACAGAAGGGGG

Downstream 100 bases:

>100_bases
ACCCCGAGGCCTGGATGTGGTACTACCGGACCGTTGGTGGTGGCAGATGCCCCATCATGGATACCTGGTGGCAGACAGAG
ACCGGGATGCACATAATAAC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFMRGQLDALLREERVFNPDEELAENSNIRAWMDARGIGGYDELLERASSDPEWFWDEMASELEWFRPYTRVLEWEPPHA
RWFTGGKFNITYSALDRHVMGPERNRVAYIWEGEDGSVRKLTYYDLYREVNRLANALKDMGVSRGDRVSIYLPMIPELPI
AMLACARIGAVHSVVFSGFWAKAFRERAADAGAKVAITADAFYRRGKVIRLKETLDMVADEIPSLERVIVVNRMGDDVSM
VDGRDIYWSEAVEGMDDECPCQELDPEDPLFILYTSGTTGKPKGVVHTHGGYAVGVSSTYRFVFDVKDQDIWWCLADIGW
ITGHSYIVYAPLIEGATSVIYEGAPDHPDPGRIWSMVERYGVSILYTAPTTVRLFMKYGDKWPEKYDLRTLRILGSVGNP

Sequences:

>Translated_400_residues
MFMRGQLDALLREERVFNPDEELAENSNIRAWMDARGIGGYDELLERASSDPEWFWDEMASELEWFRPYTRVLEWEPPHA
RWFTGGKFNITYSALDRHVMGPERNRVAYIWEGEDGSVRKLTYYDLYREVNRLANALKDMGVSRGDRVSIYLPMIPELPI
AMLACARIGAVHSVVFSGFWAKAFRERAADAGAKVAITADAFYRRGKVIRLKETLDMVADEIPSLERVIVVNRMGDDVSM
VDGRDIYWSEAVEGMDDECPCQELDPEDPLFILYTSGTTGKPKGVVHTHGGYAVGVSSTYRFVFDVKDQDIWWCLADIGW
ITGHSYIVYAPLIEGATSVIYEGAPDHPDPGRIWSMVERYGVSILYTAPTTVRLFMKYGDKWPEKYDLRTLRILGSVGNP
>Mature_400_residues
MFMRGQLDALLREERVFNPDEELAENSNIRAWMDARGIGGYDELLERASSDPEWFWDEMASELEWFRPYTRVLEWEPPHA
RWFTGGKFNITYSALDRHVMGPERNRVAYIWEGEDGSVRKLTYYDLYREVNRLANALKDMGVSRGDRVSIYLPMIPELPI
AMLACARIGAVHSVVFSGFWAKAFRERAADAGAKVAITADAFYRRGKVIRLKETLDMVADEIPSLERVIVVNRMGDDVSM
VDGRDIYWSEAVEGMDDECPCQELDPEDPLFILYTSGTTGKPKGVVHTHGGYAVGVSSTYRFVFDVKDQDIWWCLADIGW
ITGHSYIVYAPLIEGATSVIYEGAPDHPDPGRIWSMVERYGVSILYTAPTTVRLFMKYGDKWPEKYDLRTLRILGSVGNP

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=421, Percent_Identity=41.8052256532066, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI253970489, Length=434, Percent_Identity=40.5529953917051, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI28416953, Length=367, Percent_Identity=46.0490463215259, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI13375727, Length=367, Percent_Identity=36.2397820163488, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI31982927, Length=373, Percent_Identity=29.7587131367292, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI42544134, Length=308, Percent_Identity=25.3246753246753, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI42544132, Length=308, Percent_Identity=25.3246753246753, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI38505220, Length=321, Percent_Identity=25.5451713395639, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI122937307, Length=318, Percent_Identity=24.5283018867925, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI115511026, Length=261, Percent_Identity=26.8199233716475, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI58082049, Length=298, Percent_Identity=24.1610738255034, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI157311624, Length=302, Percent_Identity=24.1721854304636, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI157311622, Length=302, Percent_Identity=24.1721854304636, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790505, Length=367, Percent_Identity=45.2316076294278, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1786529, Length=363, Percent_Identity=40.2203856749311, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI221142682, Length=275, Percent_Identity=24.7272727272727, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693145, Length=278, Percent_Identity=25.1798561151079, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=409, Percent_Identity=39.6088019559902, Blast_Score=306, Evalue=9e-84,
Organism=Caenorhabditis elegans, GI71983001, Length=385, Percent_Identity=41.038961038961, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17569507, Length=359, Percent_Identity=23.1197771587744, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=280, Percent_Identity=23.2142857142857, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560308, Length=296, Percent_Identity=24.6621621621622, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=365, Percent_Identity=44.6575342465753, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6319264, Length=375, Percent_Identity=40, Blast_Score=295, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24667955, Length=413, Percent_Identity=42.1307506053269, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI62472339, Length=301, Percent_Identity=49.1694352159468, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI21355225, Length=370, Percent_Identity=36.7567567567568, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24667959, Length=264, Percent_Identity=47.7272727272727, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 45605; Mature: 45605

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMRGQLDALLREERVFNPDEELAENSNIRAWMDARGIGGYDELLERASSDPEWFWDEMA
CCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHH
SELEWFRPYTRVLEWEPPHARWFTGGKFNITYSALDRHVMGPERNRVAYIWEGEDGSVRK
HHHHHHCHHHHHCCCCCCCCCEEECCEEEEEHHHHHHHCCCCCCCEEEEEEECCCCCEEE
LTYYDLYREVNRLANALKDMGVSRGDRVSIYLPMIPELPIAMLACARIGAVHSVVFSGFW
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AKAFRERAADAGAKVAITADAFYRRGKVIRLKETLDMVADEIPSLERVIVVNRMGDDVSM
HHHHHHHHHCCCCEEEEEHHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCEE
VDGRDIYWSEAVEGMDDECPCQELDPEDPLFILYTSGTTGKPKGVVHTHGGYAVGVSSTY
CCCCCEEHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEECCCEE
RFVFDVKDQDIWWCLADIGWITGHSYIVYAPLIEGATSVIYEGAPDHPDPGRIWSMVERY
EEEEEECCCCEEEEEEHHHHHCCCCEEEEEEHHCCCHHEEECCCCCCCCCHHHHHHHHHH
GVSILYTAPTTVRLFMKYGDKWPEKYDLRTLRILGSVGNP
CCEEEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MFMRGQLDALLREERVFNPDEELAENSNIRAWMDARGIGGYDELLERASSDPEWFWDEMA
CCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHH
SELEWFRPYTRVLEWEPPHARWFTGGKFNITYSALDRHVMGPERNRVAYIWEGEDGSVRK
HHHHHHCHHHHHCCCCCCCCCEEECCEEEEEHHHHHHHCCCCCCCEEEEEEECCCCCEEE
LTYYDLYREVNRLANALKDMGVSRGDRVSIYLPMIPELPIAMLACARIGAVHSVVFSGFW
EHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AKAFRERAADAGAKVAITADAFYRRGKVIRLKETLDMVADEIPSLERVIVVNRMGDDVSM
HHHHHHHHHCCCCEEEEEHHHHHHCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCEE
VDGRDIYWSEAVEGMDDECPCQELDPEDPLFILYTSGTTGKPKGVVHTHGGYAVGVSSTY
CCCCCEEHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEECCCCEEEECCCEE
RFVFDVKDQDIWWCLADIGWITGHSYIVYAPLIEGATSVIYEGAPDHPDPGRIWSMVERY
EEEEEECCCCEEEEEEHHHHHCCCCEEEEEEHHCCCHHEEECCCCCCCCCHHHHHHHHHH
GVSILYTAPTTVRLFMKYGDKWPEKYDLRTLRILGSVGNP
CCEEEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1680850; 2571608 [H]