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Identifier: 15679563

GI number: 15679563

Start: 1434206

End: 1436206

Strand: Direct

Name: Not Available

Synonym: MTH1567

Alternate gene names: 15679563

Gene position: 1434206-1436206 (Clockwise)

Preceding gene: 15679562

Following gene: 15679568

Centisome position: 81.89

GC content: 43.63

Gene sequence:

>2001_bases
ATGAAGGTCCTGACAACATGTACAAGGGATTGCCCTGGTTCATGTGGTCTTACAGTTAATGTGAGCAGGGGTAAGGTCAA
TTCCATAGAAGGAAGCAGTATTCACCCACACACAAGGGGATTTATATGTAAAAATACAGCGAGGTATCATGTAAGGAGGC
TCTATTCTGATAGAAGGGTATTAAAACCGTTGAAGAGGGATGGGAGGCAGTGGAAAACGATATCCTGGGATGAGGCACTT
CATGTGATTTCTGATAAATTGAATGAGTGCATGGATGAACACGGAGCTGAGTCTATAGTGTATTATCAGGGTTTTGGAGC
ACGAACAGCGTTGAGACTCCTCAACAGGAGGTTTTTCAATCTCATAGGAGCAACAACTCTCAGGGGAACTCTATGCGGGG
GTGCAGCCATAGCAGCTCAATCAAAAGACTTTGGGAGGAGACTGTCCCATGATCCGTCAGATCACCTTAACAGCAGGAAC
ATATTCATATGGGGACGTAACCCTGCCGTCACAGACATTAATCTCTGGAGGATAATAAAGAGGGCCCAGAAACATGGAAC
ACGGGTTATCACAATCGATCCCATAAGGACTCAAACAGCAGTGAAATCAGATATTCACTGTCAGATTGAAGCCGGGAAGG
ACCTATACCTTGCAATAGCAATGGCGAAGATAATCATGGCTGAAGAGCTTCATGACTCTGGATTCATAGAGAAACATGCG
GAAAATTTTGATTCATATATAGAAATCCTTGATGAATTCAATTTAAATCAATTATCAGAGCTGAGTGGGGTTCCATTGAA
AATAATCTCTAAGCTTGCACACCTATACTCTGATGGGCCAAGCAGCATAATACTTGGCTGGGGTCTGCAGCGGTACTTCA
ACTCATATATGGCTTGCAGATTCATAGATGCCCTTGCAGCCATATCAGGGTATATAGGTGTGAGTGGAGGTGGTGTGAGC
AGCGGTTTTGATGAATATGGGGCCTTTGATGAATCTGTTACACTTGAAGGGGCAGGAAATGGTAGAAAAGTGTCAATGCC
CCTTTTTGGAAGGGAAATAGTGAATATGAATTCACCAACCGTTAACTGTGTATTTATAACGGCAGGTAATCCCGTGACCC
TTGGACCCAACTCCATTCAGACTCTAAATGCGCTAAGAGAAGTTGATTTTGTTGTCATGGTGGATCTCTTCTTGAATGAT
ACAGCACATACAGCCGACCTATTTTTACCCGCAACAACATTTCTGGAGGAAACAGACCTTGTTGGAAGCTATGGTCACCC
CTACGTGTCTCCTGTAAACGCTGCAGTCAAGCCATTGGGTGAATCTCATTCCGAGTTCTGGATTTTACAGAGATTATCAG
AGATCATGGGTTTTGCTGATATGGAAGGAACAAGGATGGAGTGGCTTGAAATTATAGCTTCAAAGGTTCTTGATTATCAT
GGAATAGAAATTTGTGATCTCCTGGAAAAACCATACAGATCACCGGGATTCCCTCCGGTCCCATTTGAGGGGCCTTTATT
CTATACAGACAATGGAAGGTTCAATTTACCATCGGACAGGCCTTACGAGATGGAGCAACATGATGGGGCACACCCTGAAA
ATTCCATAAGGCTTTTAACAGTCATGTCACCACAGTGGGTAGGTTCCGTTGAGCCTACCTTTCATAAAGGTCTTGTAGAA
ATTTACCTAAACCCCGGAACGCTTTCACAACTTGGTTTTAATGATGGAGAGATTTCAGTCGCGGAATCAAATGCAGGAAA
GAGTTGTGTGATTGTACGTTCCAGCGAGGATGTCCATCCACTATGCGCCCTTTCATTCAGGGGGACATGGTTATCAAAGG
GAGGCTGTATAAATACTGTCATTGAGGATAGAGAGACAATTATGGGTCATGGAACAGCTTACAACGAGACCAGAATAAAA
TTAAAAAAAGTTTCAGGCGGCGTTTCTGTTCATGAAATGTGCCATGAGACTCACAAGTATAAATCCCGCCACTATGAGTG
A

Upstream 100 bases:

>100_bases
AGATGAATCTGACTGTATATGTGGCAAGGTACTGTACTGAAATCTTTAACCGATCTGAAGATAGTTCAATTAATTTAACT
AAATACCTGGATGTAAATCA

Downstream 100 bases:

>100_bases
AACTATCTGAATGGCTGCATTCACAGTATCACCTCATTCATCAACTGCCTCGATCAGGCATACCCCACCTTCACATTCAT
GTTCAAGTTCGATGAGGTAC

Product: catalytic subunit of nitrate reductase (flp)

Products: nitrate; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MKVLTTCTRDCPGSCGLTVNVSRGKVNSIEGSSIHPHTRGFICKNTARYHVRRLYSDRRVLKPLKRDGRQWKTISWDEAL
HVISDKLNECMDEHGAESIVYYQGFGARTALRLLNRRFFNLIGATTLRGTLCGGAAIAAQSKDFGRRLSHDPSDHLNSRN
IFIWGRNPAVTDINLWRIIKRAQKHGTRVITIDPIRTQTAVKSDIHCQIEAGKDLYLAIAMAKIIMAEELHDSGFIEKHA
ENFDSYIEILDEFNLNQLSELSGVPLKIISKLAHLYSDGPSSIILGWGLQRYFNSYMACRFIDALAAISGYIGVSGGGVS
SGFDEYGAFDESVTLEGAGNGRKVSMPLFGREIVNMNSPTVNCVFITAGNPVTLGPNSIQTLNALREVDFVVMVDLFLND
TAHTADLFLPATTFLEETDLVGSYGHPYVSPVNAAVKPLGESHSEFWILQRLSEIMGFADMEGTRMEWLEIIASKVLDYH
GIEICDLLEKPYRSPGFPPVPFEGPLFYTDNGRFNLPSDRPYEMEQHDGAHPENSIRLLTVMSPQWVGSVEPTFHKGLVE
IYLNPGTLSQLGFNDGEISVAESNAGKSCVIVRSSEDVHPLCALSFRGTWLSKGGCINTVIEDRETIMGHGTAYNETRIK
LKKVSGGVSVHEMCHETHKYKSRHYE

Sequences:

>Translated_666_residues
MKVLTTCTRDCPGSCGLTVNVSRGKVNSIEGSSIHPHTRGFICKNTARYHVRRLYSDRRVLKPLKRDGRQWKTISWDEAL
HVISDKLNECMDEHGAESIVYYQGFGARTALRLLNRRFFNLIGATTLRGTLCGGAAIAAQSKDFGRRLSHDPSDHLNSRN
IFIWGRNPAVTDINLWRIIKRAQKHGTRVITIDPIRTQTAVKSDIHCQIEAGKDLYLAIAMAKIIMAEELHDSGFIEKHA
ENFDSYIEILDEFNLNQLSELSGVPLKIISKLAHLYSDGPSSIILGWGLQRYFNSYMACRFIDALAAISGYIGVSGGGVS
SGFDEYGAFDESVTLEGAGNGRKVSMPLFGREIVNMNSPTVNCVFITAGNPVTLGPNSIQTLNALREVDFVVMVDLFLND
TAHTADLFLPATTFLEETDLVGSYGHPYVSPVNAAVKPLGESHSEFWILQRLSEIMGFADMEGTRMEWLEIIASKVLDYH
GIEICDLLEKPYRSPGFPPVPFEGPLFYTDNGRFNLPSDRPYEMEQHDGAHPENSIRLLTVMSPQWVGSVEPTFHKGLVE
IYLNPGTLSQLGFNDGEISVAESNAGKSCVIVRSSEDVHPLCALSFRGTWLSKGGCINTVIEDRETIMGHGTAYNETRIK
LKKVSGGVSVHEMCHETHKYKSRHYE
>Mature_666_residues
MKVLTTCTRDCPGSCGLTVNVSRGKVNSIEGSSIHPHTRGFICKNTARYHVRRLYSDRRVLKPLKRDGRQWKTISWDEAL
HVISDKLNECMDEHGAESIVYYQGFGARTALRLLNRRFFNLIGATTLRGTLCGGAAIAAQSKDFGRRLSHDPSDHLNSRN
IFIWGRNPAVTDINLWRIIKRAQKHGTRVITIDPIRTQTAVKSDIHCQIEAGKDLYLAIAMAKIIMAEELHDSGFIEKHA
ENFDSYIEILDEFNLNQLSELSGVPLKIISKLAHLYSDGPSSIILGWGLQRYFNSYMACRFIDALAAISGYIGVSGGGVS
SGFDEYGAFDESVTLEGAGNGRKVSMPLFGREIVNMNSPTVNCVFITAGNPVTLGPNSIQTLNALREVDFVVMVDLFLND
TAHTADLFLPATTFLEETDLVGSYGHPYVSPVNAAVKPLGESHSEFWILQRLSEIMGFADMEGTRMEWLEIIASKVLDYH
GIEICDLLEKPYRSPGFPPVPFEGPLFYTDNGRFNLPSDRPYEMEQHDGAHPENSIRLLTVMSPQWVGSVEPTFHKGLVE
IYLNPGTLSQLGFNDGEISVAESNAGKSCVIVRSSEDVHPLCALSFRGTWLSKGGCINTVIEDRETIMGHGTAYNETRIK
LKKVSGGVSVHEMCHETHKYKSRHYE

Specific function: Decomposes Formic Acid To Hydrogen And Carbon Dioxide Under Anaerobic Conditions In The Absence Of Exogenous Electron Acceptors. [C]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=495, Percent_Identity=22.2222222222222, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI171474008, Length=772, Percent_Identity=22.7979274611399, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787870, Length=771, Percent_Identity=22.6977950713359, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI87081797, Length=542, Percent_Identity=26.0147601476015, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081994, Length=465, Percent_Identity=24.9462365591398, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI145693196, Length=738, Percent_Identity=22.0867208672087, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1787231, Length=460, Percent_Identity=21.9565217391304, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.7.99.4

Molecular weight: Translated: 74027; Mature: 74027

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTTCTRDCPGSCGLTVNVSRGKVNSIEGSSIHPHTRGFICKNTARYHVRRLYSDRRV
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
LKPLKRDGRQWKTISWDEALHVISDKLNECMDEHGAESIVYYQGFGARTALRLLNRRFFN
HHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
LIGATTLRGTLCGGAAIAAQSKDFGRRLSHDPSDHLNSRNIFIWGRNPAVTDINLWRIIK
HHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCHHHCCCCEEEEECCCCCCCCHHHHHHHH
RAQKHGTRVITIDPIRTQTAVKSDIHCQIEAGKDLYLAIAMAKIIMAEELHDSGFIEKHA
HHHHCCCEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
ENFDSYIEILDEFNLNQLSELSGVPLKIISKLAHLYSDGPSSIILGWGLQRYFNSYMACR
HHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
FIDALAAISGYIGVSGGGVSSGFDEYGAFDESVTLEGAGNGRKVSMPLFGREIVNMNSPT
HHHHHHHHHCCEECCCCCCCCCCHHHCCCCCCEEEEECCCCCEEECCHHCHHHCCCCCCE
VNCVFITAGNPVTLGPNSIQTLNALREVDFVVMVDLFLNDTAHTADLFLPATTFLEETDL
EEEEEEECCCEEEECCCHHHHHHHHHHCCCEEEEEEHHCCCCCHHHEEECHHHHHHHHCC
VGSYGHPYVSPVNAAVKPLGESHSEFWILQRLSEIMGFADMEGTRMEWLEIIASKVLDYH
CCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
GIEICDLLEKPYRSPGFPPVPFEGPLFYTDNGRFNLPSDRPYEMEQHDGAHPENSIRLLT
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHCCCCCCCCCEEEEE
VMSPQWVGSVEPTFHKGLVEIYLNPGTLSQLGFNDGEISVAESNAGKSCVIVRSSEDVHP
EECCCCCCCCCCHHHCCEEEEEECCCCHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCC
LCALSFRGTWLSKGGCINTVIEDRETIMGHGTAYNETRIKLKKVSGGVSVHEMCHETHKY
EEEEEECCCEECCCCEEHHHHHCCHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
KSRHYE
HHCCCC
>Mature Secondary Structure
MKVLTTCTRDCPGSCGLTVNVSRGKVNSIEGSSIHPHTRGFICKNTARYHVRRLYSDRRV
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
LKPLKRDGRQWKTISWDEALHVISDKLNECMDEHGAESIVYYQGFGARTALRLLNRRFFN
HHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
LIGATTLRGTLCGGAAIAAQSKDFGRRLSHDPSDHLNSRNIFIWGRNPAVTDINLWRIIK
HHHHHHHHHHHCCCEEEECCCHHHHHHCCCCCHHHCCCCEEEEECCCCCCCCHHHHHHHH
RAQKHGTRVITIDPIRTQTAVKSDIHCQIEAGKDLYLAIAMAKIIMAEELHDSGFIEKHA
HHHHCCCEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
ENFDSYIEILDEFNLNQLSELSGVPLKIISKLAHLYSDGPSSIILGWGLQRYFNSYMACR
HHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
FIDALAAISGYIGVSGGGVSSGFDEYGAFDESVTLEGAGNGRKVSMPLFGREIVNMNSPT
HHHHHHHHHCCEECCCCCCCCCCHHHCCCCCCEEEEECCCCCEEECCHHCHHHCCCCCCE
VNCVFITAGNPVTLGPNSIQTLNALREVDFVVMVDLFLNDTAHTADLFLPATTFLEETDL
EEEEEEECCCEEEECCCHHHHHHHHHHCCCEEEEEEHHCCCCCHHHEEECHHHHHHHHCC
VGSYGHPYVSPVNAAVKPLGESHSEFWILQRLSEIMGFADMEGTRMEWLEIIASKVLDYH
CCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
GIEICDLLEKPYRSPGFPPVPFEGPLFYTDNGRFNLPSDRPYEMEQHDGAHPENSIRLLT
CCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHCCCCCCCCCEEEEE
VMSPQWVGSVEPTFHKGLVEIYLNPGTLSQLGFNDGEISVAESNAGKSCVIVRSSEDVHP
EECCCCCCCCCCHHHCCEEEEEECCCCHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCC
LCALSFRGTWLSKGGCINTVIEDRETIMGHGTAYNETRIKLKKVSGGVSVHEMCHETHKY
EEEEEECCCEECCCCEEHHHHHCCHHHEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHH
KSRHYE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nitrite; acceptor

Specific reaction: nitrite + acceptor = nitrate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1552862 [H]