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Identifier: 15679452

GI number: 15679452

Start: 1316121

End: 1317938

Strand: Direct

Name: Not Available

Synonym: MTH1455

Alternate gene names: 15679452

Gene position: 1316121-1317938 (Clockwise)

Preceding gene: 15679451

Following gene: 15679453

Centisome position: 75.15

GC content: 50.22

Gene sequence:

>1818_bases
ATGAGGATACTGTTAATTCACTCTGATTACTTGAAATACGAGACAAAGAATAAAACAGGGATAGCAGAGGAAATCCCTGA
AGATAAGATGCAGGGAGATTTCAGGGAGTCCCTGGTGGTTTTCACAGCAGTGGAGGCTGAAGATGAGGATAACCCTGAAT
CAGTAATTGAAAACGCGGTTAATGAAATAATAAAGGTTTTCAATGACGTTAAGGCAGAGAACGTCGTGATATACCCTTAC
GCACACCTCAGCTCCTCGCTCAGCTCCCCCAAAACAGCGGTGGAGGTCCTTGAGGGAATGGAATCAGCCCTCCGCAGCGA
GGGTGTTGATGTCTCAAGGGTTCCTTTCGGGTGGTATAAGGCCTTCAAGATATCCTGCAAGGGTCACCCACTATCAGAGC
TATCAAGGAGCATAAGGCCACAGCCCCCAAAGGTGGAGGAGGAGAGCGAGGAATCCGAGTGGTTCATACTCCACAGGGGA
GAGACGGTTAAACCCGGAGACTTCGAGTTCAAAAACAGGGATCTTGAGAACCTGGTGAAATATGAGCTTGGCGAACTTGA
ATCCTCTGGTGAAGAACCACCACACGTTAGACTCATGAGGGAGAAGGGACTTGCAGACTATGAGCCATCAGCAGACGTTG
GACACCTCCGGTGGTACCCCAGGGGAAGGCTGATAAGGGACCTTCTTGCAGACTACGTCTACATGCTTGTCACCAGTGAG
GGGGCAATGCCAGTTGAGACACCCATAATGTATGACCTCGAGGACGAGGCAATCAGGGTACATGCAGAGAAGTTCGGTGA
AAGACAGTACAGGATGAAGAACAGGAAGGAACTCATGCTGAGATACGCCTGCTGTTTCGGAGCCTTCAGGATCCTTTCAG
ACTCCTTCCTGACGTGGAAGAACCTGCCTGCATCCATATATGAACTCTCGACCTACAGCTTCCGGCTTGAAAAGAAGGGC
GAGGTGGTTGGTCTTAAGAGGCTCAGGGGCTTTACAATGCCGGATCTCCACACGGTATGTGCTGACCTTGATCAGTCCCT
TGAGGAATTCGCCAGGCAGGTCGAGATGTGCATGAGGACCGGCCAGGACCTCCAGGTGAACTATGAGGTCATATTCAGGG
CCACGGCTGACTTCTATGAGGAGTACAGGGAATGGGTACATGAAGTAGCGGATAAAATCGGAAAACCAGTGCTCCTGGAG
ATACTCCCCTCAAGGAAGCACTACTGGATTGCCAAGATGGACTTCGCAGCCATAGACTACCTTGGAAGACCGATAGAGAA
TCCAACAGTTCAGATTGACGTTGAAAGCGGTGAGAGGTTCGGGATAACCTATGTTAACAGTGATGAGGAGGAGGTAAACC
CAATAATCCTCCACTGCAGTCCAACAGGCAGCATTGAGAGGGTCATATGCAGCCTTCTTGAGAAGACGGCCATTGAAATG
GATGAAAAACCACCTATGCTGCCCTTGTGGCTCTCACCCACCCAGGTACGTGTGCTTCCAATTGCAGAGCGCCACATGGA
ATATGCCAGTGACCTGGTATCAGAACTTATCGCAGCTGACGTAAGGGCTGACCTGGATGACCGATCAGAGACCCTCGGAA
AGAAGATAAGGAATGCGGCCCAGGACTGGGTCCCCTACGTTGTTGTTATAGGTGACAGTGAAATGGAGGGCAAACTCACG
GTCAATGTGAGGGAAACAGGTGAAAAGCTTCAGATGGGCCTGGATGAACTCATAGAACGTATAAGGGCTGAAACAGAGGG
CATGCCCTTCAGAAGACTGCCGCTACCGGTTAAACTATCCGAGAGGATAAACTTCTAA

Upstream 100 bases:

>100_bases
CATCTGAACATTACTAGGGGTTTAAAGATCCACCGGAGCAATATTTAAAAACCCTCACCTTAAAAACAATAACATTAGTT
ATTCTTACCAAGGTGATGGC

Downstream 100 bases:

>100_bases
TAATTTTTTTTAATCTGATAACTTATAACTTATCACATATACTTTATAAGTTATAAATTATAACTTAGATCCAGCAGGTG
ATGAGATGGGAGAGGTAATT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MRILLIHSDYLKYETKNKTGIAEEIPEDKMQGDFRESLVVFTAVEAEDEDNPESVIENAVNEIIKVFNDVKAENVVIYPY
AHLSSSLSSPKTAVEVLEGMESALRSEGVDVSRVPFGWYKAFKISCKGHPLSELSRSIRPQPPKVEEESEESEWFILHRG
ETVKPGDFEFKNRDLENLVKYELGELESSGEEPPHVRLMREKGLADYEPSADVGHLRWYPRGRLIRDLLADYVYMLVTSE
GAMPVETPIMYDLEDEAIRVHAEKFGERQYRMKNRKELMLRYACCFGAFRILSDSFLTWKNLPASIYELSTYSFRLEKKG
EVVGLKRLRGFTMPDLHTVCADLDQSLEEFARQVEMCMRTGQDLQVNYEVIFRATADFYEEYREWVHEVADKIGKPVLLE
ILPSRKHYWIAKMDFAAIDYLGRPIENPTVQIDVESGERFGITYVNSDEEEVNPIILHCSPTGSIERVICSLLEKTAIEM
DEKPPMLPLWLSPTQVRVLPIAERHMEYASDLVSELIAADVRADLDDRSETLGKKIRNAAQDWVPYVVVIGDSEMEGKLT
VNVRETGEKLQMGLDELIERIRAETEGMPFRRLPLPVKLSERINF

Sequences:

>Translated_605_residues
MRILLIHSDYLKYETKNKTGIAEEIPEDKMQGDFRESLVVFTAVEAEDEDNPESVIENAVNEIIKVFNDVKAENVVIYPY
AHLSSSLSSPKTAVEVLEGMESALRSEGVDVSRVPFGWYKAFKISCKGHPLSELSRSIRPQPPKVEEESEESEWFILHRG
ETVKPGDFEFKNRDLENLVKYELGELESSGEEPPHVRLMREKGLADYEPSADVGHLRWYPRGRLIRDLLADYVYMLVTSE
GAMPVETPIMYDLEDEAIRVHAEKFGERQYRMKNRKELMLRYACCFGAFRILSDSFLTWKNLPASIYELSTYSFRLEKKG
EVVGLKRLRGFTMPDLHTVCADLDQSLEEFARQVEMCMRTGQDLQVNYEVIFRATADFYEEYREWVHEVADKIGKPVLLE
ILPSRKHYWIAKMDFAAIDYLGRPIENPTVQIDVESGERFGITYVNSDEEEVNPIILHCSPTGSIERVICSLLEKTAIEM
DEKPPMLPLWLSPTQVRVLPIAERHMEYASDLVSELIAADVRADLDDRSETLGKKIRNAAQDWVPYVVVIGDSEMEGKLT
VNVRETGEKLQMGLDELIERIRAETEGMPFRRLPLPVKLSERINF
>Mature_605_residues
MRILLIHSDYLKYETKNKTGIAEEIPEDKMQGDFRESLVVFTAVEAEDEDNPESVIENAVNEIIKVFNDVKAENVVIYPY
AHLSSSLSSPKTAVEVLEGMESALRSEGVDVSRVPFGWYKAFKISCKGHPLSELSRSIRPQPPKVEEESEESEWFILHRG
ETVKPGDFEFKNRDLENLVKYELGELESSGEEPPHVRLMREKGLADYEPSADVGHLRWYPRGRLIRDLLADYVYMLVTSE
GAMPVETPIMYDLEDEAIRVHAEKFGERQYRMKNRKELMLRYACCFGAFRILSDSFLTWKNLPASIYELSTYSFRLEKKG
EVVGLKRLRGFTMPDLHTVCADLDQSLEEFARQVEMCMRTGQDLQVNYEVIFRATADFYEEYREWVHEVADKIGKPVLLE
ILPSRKHYWIAKMDFAAIDYLGRPIENPTVQIDVESGERFGITYVNSDEEEVNPIILHCSPTGSIERVICSLLEKTAIEM
DEKPPMLPLWLSPTQVRVLPIAERHMEYASDLVSELIAADVRADLDDRSETLGKKIRNAAQDWVPYVVVIGDSEMEGKLT
VNVRETGEKLQMGLDELIERIRAETEGMPFRRLPLPVKLSERINF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=371, Percent_Identity=26.1455525606469, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI38202255, Length=384, Percent_Identity=25.78125, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI20070344, Length=415, Percent_Identity=24.578313253012, Blast_Score=106, Evalue=8e-23,
Organism=Escherichia coli, GI1788013, Length=402, Percent_Identity=26.1194029850746, Blast_Score=129, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71984184, Length=419, Percent_Identity=25.0596658711217, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71984192, Length=419, Percent_Identity=25.0596658711217, Blast_Score=125, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6322654, Length=403, Percent_Identity=24.5657568238213, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322112, Length=393, Percent_Identity=24.4274809160305, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583839, Length=412, Percent_Identity=26.4563106796117, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24583842, Length=412, Percent_Identity=26.4563106796117, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574141, Length=412, Percent_Identity=26.4563106796117, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_METTH (O27504)

Other databases:

- EMBL:   AE000666
- PIR:   G69060
- RefSeq:   NP_276569.1
- ProteinModelPortal:   O27504
- SMR:   O27504
- STRING:   O27504
- GeneID:   1471724
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1455
- NMPDR:   fig|187420.1.peg.1424
- eggNOG:   arNOG04477
- HOGENOM:   HBG392335
- OMA:   ETPVMYD
- ProtClustDB:   PRK03991
- BioCyc:   MTHE187420:MTH1455-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_A
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR015011
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- ProDom:   PD016189
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF08915 tRNA-Thr_ED; SSF52954 Anticodon_bd

EC number: =6.1.1.3

Molecular weight: Translated: 69540; Mature: 69540

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLIHSDYLKYETKNKTGIAEEIPEDKMQGDFRESLVVFTAVEAEDEDNPESVIENAV
CEEEEEECHHHEEECCCCCCCHHHCCCHHHCCHHHHCEEEEEEEECCCCCCHHHHHHHHH
NEIIKVFNDVKAENVVIYPYAHLSSSLSSPKTAVEVLEGMESALRSEGVDVSRVPFGWYK
HHHHHHHHCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCEEE
AFKISCKGHPLSELSRSIRPQPPKVEEESEESEWFILHRGETVKPGDFEFKNRDLENLVK
EEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
YELGELESSGEEPPHVRLMREKGLADYEPSADVGHLRWYPRGRLIRDLLADYVYMLVTSE
HHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
GAMPVETPIMYDLEDEAIRVHAEKFGERQYRMKNRKELMLRYACCFGAFRILSDSFLTWK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
NLPASIYELSTYSFRLEKKGEVVGLKRLRGFTMPDLHTVCADLDQSLEEFARQVEMCMRT
CCCCHHEECCCEEEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GQDLQVNYEVIFRATADFYEEYREWVHEVADKIGKPVLLEILPSRKHYWIAKMDFAAIDY
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHH
LGRPIENPTVQIDVESGERFGITYVNSDEEEVNPIILHCSPTGSIERVICSLLEKTAIEM
HCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
DEKPPMLPLWLSPTQVRVLPIAERHMEYASDLVSELIAADVRADLDDRSETLGKKIRNAA
CCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QDWVPYVVVIGDSEMEGKLTVNVRETGEKLQMGLDELIERIRAETEGMPFRRLPLPVKLS
HCCCCEEEEECCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHH
ERINF
CCCCC
>Mature Secondary Structure
MRILLIHSDYLKYETKNKTGIAEEIPEDKMQGDFRESLVVFTAVEAEDEDNPESVIENAV
CEEEEEECHHHEEECCCCCCCHHHCCCHHHCCHHHHCEEEEEEEECCCCCCHHHHHHHHH
NEIIKVFNDVKAENVVIYPYAHLSSSLSSPKTAVEVLEGMESALRSEGVDVSRVPFGWYK
HHHHHHHHCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCEEE
AFKISCKGHPLSELSRSIRPQPPKVEEESEESEWFILHRGETVKPGDFEFKNRDLENLVK
EEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
YELGELESSGEEPPHVRLMREKGLADYEPSADVGHLRWYPRGRLIRDLLADYVYMLVTSE
HHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCC
GAMPVETPIMYDLEDEAIRVHAEKFGERQYRMKNRKELMLRYACCFGAFRILSDSFLTWK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
NLPASIYELSTYSFRLEKKGEVVGLKRLRGFTMPDLHTVCADLDQSLEEFARQVEMCMRT
CCCCHHEECCCEEEEECCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GQDLQVNYEVIFRATADFYEEYREWVHEVADKIGKPVLLEILPSRKHYWIAKMDFAAIDY
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEHHHHHHH
LGRPIENPTVQIDVESGERFGITYVNSDEEEVNPIILHCSPTGSIERVICSLLEKTAIEM
HCCCCCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCC
DEKPPMLPLWLSPTQVRVLPIAERHMEYASDLVSELIAADVRADLDDRSETLGKKIRNAA
CCCCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QDWVPYVVVIGDSEMEGKLTVNVRETGEKLQMGLDELIERIRAETEGMPFRRLPLPVKLS
HCCCCEEEEECCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHH
ERINF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463