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Identifier: 15679275

GI number: 15679275

Start: 1155786

End: 1157225

Strand: Direct

Name: Not Available

Synonym: MTH1264

Alternate gene names: 15679275

Gene position: 1155786-1157225 (Clockwise)

Preceding gene: 15679274

Following gene: 15679276

Centisome position: 65.99

GC content: 50.28

Gene sequence:

>1440_bases
TTGGTACTTATGAGATACGTTGGAAAGCGGGACCTTTTTACAGTGGGCAAGTATCTTGGCACGATAATGCAGGGAGTGGG
TTTTGTTGTTGCACTGCCAGTCTTCGTTGCCATCATCTACGGTGAGGGCAACCTGCAGAGTTTCATTATACCTGCATTCA
TTTCTCTGGGTGCAGGGACCGTCCTGAAGAGGTACCTGCCCGAGGAATGTTCAGTGCGCCTCAAGCACGGGATGATGGTT
GCATGCCTGGCATGGCTATGGGCAGGGCTCATCGGGAGCCTCATAATGATATCTGCCCTCAACATTGACTTTACAAACGC
ATTCTTTGAGAACATGTCTGCATGGACAGGAAGCGGGCTCACCATATTCTCCAGTGTAGAATCCCTCCCTAAATCCATAC
TGTTTTTAAGAAGCCTTGAGCAGTGGATAGGGGGCCTTGGTGTGGTCATAGTTGTTATAGGAATACTCATAAGGCCCGGT
ACCGCTGCATCGCGTCTCTACAAGTCCGAGGCCAGGGATGAAAGAATAAAGCCCAGCATAGCAAATACAGTTAAGACCAT
CTGGTGGATCTACATAACCTACACCGTTCTCGGGATCGTCCTCTACGGCCTCACAGGGATGCCCCTCTTTGACGCCATCA
ACAATACCCTGACAAATCTGTCCACCGGTGGGATGTCAATTAAGAACATGAACATAGGATACTATCACAGCGCCGCCGTT
TACCTTGTAACCATGCTCCTCATGATACTGGGAGGTACGAGTTTCCTTGTCCACTATCAGCTCATAAAGGGCAGGTTTTT
CAGTGTGCTTCATGATATACAGTTACAGGCCACCGTGGTCTTTATAAGCATCTTCACCATCCTTGCAGTCTACGTCGGGG
GTGTTGCCCCTCTGGAGTCCATCTACCATGTTATATCGGCACTGAGCTGTACCGGTTCAAGCATAAGTTCAACCCCCCAG
ATGGTGGCATGGCCGGCATACTTCAAGGTTTTGCTCATAACCTGTATGCTCATAGGAATGGCTGCCGGTTCAACCACCGG
GGCCGTCAAGATAATCAGGGTGATAACCGTCCTCAAGGGGGTTTACTGGGAGATCATGCGAATACTCGCCCCTGAGGGAT
CAGTTATGCCAAGGAAGATATCAGGGAAGTCTGTGAGTGACACCGAGATAAGGGAGGCGGGTTCCTATATAAGCCTCTAC
TTTGTCCTTCTATTCTTCACATGGTCGGTCCTTGTGGTCTACGGTTATGACCCCCTAAATTCACTCTTTGAGGCCGCCTC
TGCCCAGGGAAACGTGGGGCTCAGCATGGGTATAACCAGCTTCAATTTACCCGTCGTCCCGAAGATGGCCCTCATCCTGA
GCATGTGGCTTGGAAGGCTTGAGATAATCCCTGTAATTGTGCTTATACGGGGCCTTGTGGAGGCATTCAAGGCAGGCTGA

Upstream 100 bases:

>100_bases
CTCTAAAAACCTATATTGCAATATCCTGACGCTACTCAACTACTATCCACCCATAACCTGCCGCTCTAAAAATTTATATT
GCAATGTTCCCATTCATATA

Downstream 100 bases:

>100_bases
TGCTCAACCCATAAAAAATGATCTGGAGTTACTGAAACCCTTATTATAAGTGGAAAAACCTTATTAATGATGAGGTTTAA
CACAAGTAAACACCACTTAC

Product: TRK system potassium uptake protein TrkH

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MVLMRYVGKRDLFTVGKYLGTIMQGVGFVVALPVFVAIIYGEGNLQSFIIPAFISLGAGTVLKRYLPEECSVRLKHGMMV
ACLAWLWAGLIGSLIMISALNIDFTNAFFENMSAWTGSGLTIFSSVESLPKSILFLRSLEQWIGGLGVVIVVIGILIRPG
TAASRLYKSEARDERIKPSIANTVKTIWWIYITYTVLGIVLYGLTGMPLFDAINNTLTNLSTGGMSIKNMNIGYYHSAAV
YLVTMLLMILGGTSFLVHYQLIKGRFFSVLHDIQLQATVVFISIFTILAVYVGGVAPLESIYHVISALSCTGSSISSTPQ
MVAWPAYFKVLLITCMLIGMAAGSTTGAVKIIRVITVLKGVYWEIMRILAPEGSVMPRKISGKSVSDTEIREAGSYISLY
FVLLFFTWSVLVVYGYDPLNSLFEAASAQGNVGLSMGITSFNLPVVPKMALILSMWLGRLEIIPVIVLIRGLVEAFKAG

Sequences:

>Translated_479_residues
MVLMRYVGKRDLFTVGKYLGTIMQGVGFVVALPVFVAIIYGEGNLQSFIIPAFISLGAGTVLKRYLPEECSVRLKHGMMV
ACLAWLWAGLIGSLIMISALNIDFTNAFFENMSAWTGSGLTIFSSVESLPKSILFLRSLEQWIGGLGVVIVVIGILIRPG
TAASRLYKSEARDERIKPSIANTVKTIWWIYITYTVLGIVLYGLTGMPLFDAINNTLTNLSTGGMSIKNMNIGYYHSAAV
YLVTMLLMILGGTSFLVHYQLIKGRFFSVLHDIQLQATVVFISIFTILAVYVGGVAPLESIYHVISALSCTGSSISSTPQ
MVAWPAYFKVLLITCMLIGMAAGSTTGAVKIIRVITVLKGVYWEIMRILAPEGSVMPRKISGKSVSDTEIREAGSYISLY
FVLLFFTWSVLVVYGYDPLNSLFEAASAQGNVGLSMGITSFNLPVVPKMALILSMWLGRLEIIPVIVLIRGLVEAFKAG
>Mature_479_residues
MVLMRYVGKRDLFTVGKYLGTIMQGVGFVVALPVFVAIIYGEGNLQSFIIPAFISLGAGTVLKRYLPEECSVRLKHGMMV
ACLAWLWAGLIGSLIMISALNIDFTNAFFENMSAWTGSGLTIFSSVESLPKSILFLRSLEQWIGGLGVVIVVIGILIRPG
TAASRLYKSEARDERIKPSIANTVKTIWWIYITYTVLGIVLYGLTGMPLFDAINNTLTNLSTGGMSIKNMNIGYYHSAAV
YLVTMLLMILGGTSFLVHYQLIKGRFFSVLHDIQLQATVVFISIFTILAVYVGGVAPLESIYHVISALSCTGSSISSTPQ
MVAWPAYFKVLLITCMLIGMAAGSTTGAVKIIRVITVLKGVYWEIMRILAPEGSVMPRKISGKSVSDTEIREAGSYISLY
FVLLFFTWSVLVVYGYDPLNSLFEAASAQGNVGLSMGITSFNLPVVPKMALILSMWLGRLEIIPVIVLIRGLVEAFKAG

Specific function: Low-Affinity Potassium Transport System. Interacts With Trk System Potassium Uptake Protein Trka. Trke Increases The Affinity Of The System. [C]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI1787626, Length=420, Percent_Identity=32.1428571428571, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI48994987, Length=459, Percent_Identity=27.6688453159041, Blast_Score=174, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 52242; Mature: 52242

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLMRYVGKRDLFTVGKYLGTIMQGVGFVVALPVFVAIIYGEGNLQSFIIPAFISLGAGT
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHH
VLKRYLPEECSVRLKHGMMVACLAWLWAGLIGSLIMISALNIDFTNAFFENMSAWTGSGL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
TIFSSVESLPKSILFLRSLEQWIGGLGVVIVVIGILIRPGTAASRLYKSEARDERIKPSI
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHH
ANTVKTIWWIYITYTVLGIVLYGLTGMPLFDAINNTLTNLSTGGMSIKNMNIGYYHSAAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
YLVTMLLMILGGTSFLVHYQLIKGRFFSVLHDIQLQATVVFISIFTILAVYVGGVAPLES
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IYHVISALSCTGSSISSTPQMVAWPAYFKVLLITCMLIGMAAGSTTGAVKIIRVITVLKG
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VYWEIMRILAPEGSVMPRKISGKSVSDTEIREAGSYISLYFVLLFFTWSVLVVYGYDPLN
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHH
SLFEAASAQGNVGLSMGITSFNLPVVPKMALILSMWLGRLEIIPVIVLIRGLVEAFKAG
HHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVLMRYVGKRDLFTVGKYLGTIMQGVGFVVALPVFVAIIYGEGNLQSFIIPAFISLGAGT
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHH
VLKRYLPEECSVRLKHGMMVACLAWLWAGLIGSLIMISALNIDFTNAFFENMSAWTGSGL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
TIFSSVESLPKSILFLRSLEQWIGGLGVVIVVIGILIRPGTAASRLYKSEARDERIKPSI
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHH
ANTVKTIWWIYITYTVLGIVLYGLTGMPLFDAINNTLTNLSTGGMSIKNMNIGYYHSAAV
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
YLVTMLLMILGGTSFLVHYQLIKGRFFSVLHDIQLQATVVFISIFTILAVYVGGVAPLES
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IYHVISALSCTGSSISSTPQMVAWPAYFKVLLITCMLIGMAAGSTTGAVKIIRVITVLKG
HHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VYWEIMRILAPEGSVMPRKISGKSVSDTEIREAGSYISLYFVLLFFTWSVLVVYGYDPLN
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHH
SLFEAASAQGNVGLSMGITSFNLPVVPKMALILSMWLGRLEIIPVIVLIRGLVEAFKAG
HHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]