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Identifier: 15679226

GI number: 15679226

Start: 1117886

End: 1118560

Strand: Direct

Name: Not Available

Synonym: MTH1215

Alternate gene names: 15679226

Gene position: 1117886-1118560 (Clockwise)

Preceding gene: 15679225

Following gene: 15679242

Centisome position: 63.83

GC content: 51.26

Gene sequence:

>675_bases
GTGTATGCTGTGAAGGAAGTTAAGGGTATGGATGGTGTCTTTATCATGAACAACTCCCTCCTCACCATTAACCCCAACCC
CGGTGTGAAGGTCTATGGTGAGAGGATCATTGATTGGGGCGGCCGGGAGTACCGGGTCTGGGATCCCCGGCGGTCCAAGC
TTGCTGCGGCCATACTTAACGGTCTGCGGGGTTTCAGTCTGAATTCAGACTCCAGGGTTCTCTATCTGGGTGCATCGGCC
GGGACAACTGCCTCACACATATCTGATATCGTCACGGATGGGAGGGTCTACTGCATCGAATTCTCTCCCAGGATGATGCG
GGAACTCCTGGGTGTGTGTGAATCCAGAAAAAACATGGCCCCCCTCCTTGAGGACGCCTCAAGACCCCTCAGTTACCTGA
GGATGGTTGAGGCCGCTGATCTCGTGTACTGTGATGTTGCACAGCCTGACCAGACCAGGTTATTCATTGAGAATATGGAT
TGCTTCCTGAAGAGGGATGGTTATGGACTCATAATGATAAAGGCCCGGAGCATAGATGTTACAAGAAGTCCCAGAAAGAT
CTTCCGGGAGGAAGTGGGGAAGCTTGAGTCTTCTGGTTTCAGAATAATTGATCAGGTGGGTCTCAATCCCTACGAAAAGG
ACCATATGGCGGTTCTGGTTAAAAGGGATGTTTAG

Upstream 100 bases:

>100_bases
GAATCATTCAATGAGAGGTTTGAAGCCATTAAAAGTAATAACCCGAAGCCCCCGGCAAGGAAGAAGGGTTTTAGAAAGAA
GAGGAAATGATAGCGGGCAG

Downstream 100 bases:

>100_bases
AAGGGCATATGATTTTTTGATATATTTTTAGTAAAAAAAGGTATATATTGGATTAATTACATAATTTCAATCCCAACTGC
AGGCCATAATTTCACCTCCG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MYAVKEVKGMDGVFIMNNSLLTINPNPGVKVYGERIIDWGGREYRVWDPRRSKLAAAILNGLRGFSLNSDSRVLYLGASA
GTTASHISDIVTDGRVYCIEFSPRMMRELLGVCESRKNMAPLLEDASRPLSYLRMVEAADLVYCDVAQPDQTRLFIENMD
CFLKRDGYGLIMIKARSIDVTRSPRKIFREEVGKLESSGFRIIDQVGLNPYEKDHMAVLVKRDV

Sequences:

>Translated_224_residues
MYAVKEVKGMDGVFIMNNSLLTINPNPGVKVYGERIIDWGGREYRVWDPRRSKLAAAILNGLRGFSLNSDSRVLYLGASA
GTTASHISDIVTDGRVYCIEFSPRMMRELLGVCESRKNMAPLLEDASRPLSYLRMVEAADLVYCDVAQPDQTRLFIENMD
CFLKRDGYGLIMIKARSIDVTRSPRKIFREEVGKLESSGFRIIDQVGLNPYEKDHMAVLVKRDV
>Mature_224_residues
MYAVKEVKGMDGVFIMNNSLLTINPNPGVKVYGERIIDWGGREYRVWDPRRSKLAAAILNGLRGFSLNSDSRVLYLGASA
GTTASHISDIVTDGRVYCIEFSPRMMRELLGVCESRKNMAPLLEDASRPLSYLRMVEAADLVYCDVAQPDQTRLFIENMD
CFLKRDGYGLIMIKARSIDVTRSPRKIFREEVGKLESSGFRIIDQVGLNPYEKDHMAVLVKRDV

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family

Homologues:

Organism=Homo sapiens, GI12056465, Length=217, Percent_Identity=43.778801843318, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17563672, Length=218, Percent_Identity=44.954128440367, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320190, Length=223, Percent_Identity=42.152466367713, Blast_Score=165, Evalue=6e-42,
Organism=Drosophila melanogaster, GI17647425, Length=217, Percent_Identity=45.1612903225806, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24646406, Length=227, Percent_Identity=32.5991189427313, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLPA_METTH (O27283)

Other databases:

- EMBL:   AE000666
- PIR:   C69029
- RefSeq:   NP_276343.1
- ProteinModelPortal:   O27283
- SMR:   O27283
- STRING:   O27283
- GeneID:   1471623
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1215
- NMPDR:   fig|187420.1.peg.1198
- eggNOG:   arNOG06356
- HOGENOM:   HBG297404
- OMA:   VNIEPFE
- PhylomeDB:   O27283
- ProtClustDB:   PRK04266
- BioCyc:   MTHE187420:MTH1215-MONOMER
- HAMAP:   MF_00351
- InterPro:   IPR000692
- InterPro:   IPR020813
- PANTHER:   PTHR10335
- PIRSF:   PIRSF006540
- PRINTS:   PR00052

Pfam domain/function: PF01269 Fibrillarin

EC number: NA

Molecular weight: Translated: 25306; Mature: 25306

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00566 FIBRILLARIN

Important sites: BINDING 53-53 BINDING 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAVKEVKGMDGVFIMNNSLLTINPNPGVKVYGERIIDWGGREYRVWDPRRSKLAAAILN
CCCCCCCCCCCCEEEEECEEEEECCCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHH
GLRGFSLNSDSRVLYLGASAGTTASHISDIVTDGRVYCIEFSPRMMRELLGVCESRKNMA
HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCC
PLLEDASRPLSYLRMVEAADLVYCDVAQPDQTRLFIENMDCFLKRDGYGLIMIKARSIDV
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEEECCCEEEEEEEECCCC
TRSPRKIFREEVGKLESSGFRIIDQVGLNPYEKDHMAVLVKRDV
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MYAVKEVKGMDGVFIMNNSLLTINPNPGVKVYGERIIDWGGREYRVWDPRRSKLAAAILN
CCCCCCCCCCCCEEEEECEEEEECCCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHH
GLRGFSLNSDSRVLYLGASAGTTASHISDIVTDGRVYCIEFSPRMMRELLGVCESRKNMA
HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCC
PLLEDASRPLSYLRMVEAADLVYCDVAQPDQTRLFIENMDCFLKRDGYGLIMIKARSIDV
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEECCEEEEEECCCEEEEEEEECCCC
TRSPRKIFREEVGKLESSGFRIIDQVGLNPYEKDHMAVLVKRDV
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463