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Identifier: 15679225

GI number: 15679225

Start: 1116763

End: 1117875

Strand: Direct

Name: Not Available

Synonym: MTH1214

Alternate gene names: NA

Gene position: 1116763-1117875 (Clockwise)

Preceding gene: 15679221

Following gene: 15679226

Centisome position: 63.76

GC content: 51.39

Gene sequence:

>1113_bases
ATGAAGTGTTATCTTACAGGTTGCATTGCAGGTCCTCTTGCCTTCAGTGAAGATCTGGAGCTCATAGATTATGAACCTTT
CCCGGTTGATGAAATCCCCGGAAGGCTTGCTGAGTCACAGATGGGTGGTGTTTCACCGGAGGAGAGGATTATGCTCGAGA
GGCTCACCCCTGAATACGATGAGGTTGTGGTTGAGGCCTCCCCCTCTCCGGAGTATGCCGGGTTCAGGAACCTCAGATTT
GAGGTTCCAAGCAGGGCAGGCATCCACCTTAGGGAGAACCTTGAGGACATCCTGGCAGAAATCCTTGATATGCCCGCCGG
AGACTTCATACATGACGCCCTCATGTCGGTTGCACGTGAAAGGCTGAGGGAGTCCCTCCGGGAGACAGACAGGTTCATAA
TACAGTCCATAAATGCCCTTGATGAACTTGATGAGGAGACCGGGAAGCTCATAGAAAGGCTGAGAGAATGGTACTCCCTC
CACTTCCCTGAACTCGACGGTATTAAGAGTCATGAACAGTACGTTGAGCTCATTGCAGAGTACGGTGACCGGGACCAGAT
ACTGAAAAATTTCAGGATGGACGTTGATGAGAGTCTTGGCTCAGATATCACCTCCGAGGACCTCCACATCCTCAGGGGCC
TTGCAGAGAGTATAAGGGGTCTTCAGAGGCTGAGGGAGGAGACAGAGAGGTACATTGACATCAAGATGGAGAAGCTTGCC
CCCAACCTCAGGGCCCTTGCAGGGTCAAATGTTGGTGCGAGGCTCATTGCCCATGCCGGAGGATTGAGGGAACTTGCCAT
GCTACCATCCTCCACAATACAGGTCCTTGGAGCTGAGAAGGCCCTCTTCAGACACCTGAAATCCGGTGCAAAGCCACCGA
AGCATGGGGTTATATTCCAGCACCCCTCGATAAGGTCATCCCCCTGGTGGATCAGGGGAAAGGTTGCAAGGCTGCTGGCG
GGTAAGATAGCCATCGCAGTTAGAAAGGACGTTTTCAGCAGAGAATTTGATCCGGGAATAGTTGAATCATTCAATGAGAG
GTTTGAAGCCATTAAAAGTAATAACCCGAAGCCCCCGGCAAGGAAGAAGGGTTTTAGAAAGAAGAGGAAATGA

Upstream 100 bases:

>100_bases
TGGTCGGGTTCCGGAGTTCAATATTACATATGCTGGTCTCAAGCATGAAAAACACCTTCTGCTAAATATATTTATATCCG
TCACCTATAGATGTACCCCT

Downstream 100 bases:

>100_bases
TAGCGGGCAGGTGTATGCTGTGAAGGAAGTTAAGGGTATGGATGGTGTCTTTATCATGAACAACTCCCTCCTCACCATTA
ACCCCAACCCCGGTGTGAAG

Product: pre-mRNA splicing protein PRP31

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKCYLTGCIAGPLAFSEDLELIDYEPFPVDEIPGRLAESQMGGVSPEERIMLERLTPEYDEVVVEASPSPEYAGFRNLRF
EVPSRAGIHLRENLEDILAEILDMPAGDFIHDALMSVARERLRESLRETDRFIIQSINALDELDEETGKLIERLREWYSL
HFPELDGIKSHEQYVELIAEYGDRDQILKNFRMDVDESLGSDITSEDLHILRGLAESIRGLQRLREETERYIDIKMEKLA
PNLRALAGSNVGARLIAHAGGLRELAMLPSSTIQVLGAEKALFRHLKSGAKPPKHGVIFQHPSIRSSPWWIRGKVARLLA
GKIAIAVRKDVFSREFDPGIVESFNERFEAIKSNNPKPPARKKGFRKKRK

Sequences:

>Translated_370_residues
MKCYLTGCIAGPLAFSEDLELIDYEPFPVDEIPGRLAESQMGGVSPEERIMLERLTPEYDEVVVEASPSPEYAGFRNLRF
EVPSRAGIHLRENLEDILAEILDMPAGDFIHDALMSVARERLRESLRETDRFIIQSINALDELDEETGKLIERLREWYSL
HFPELDGIKSHEQYVELIAEYGDRDQILKNFRMDVDESLGSDITSEDLHILRGLAESIRGLQRLREETERYIDIKMEKLA
PNLRALAGSNVGARLIAHAGGLRELAMLPSSTIQVLGAEKALFRHLKSGAKPPKHGVIFQHPSIRSSPWWIRGKVARLLA
GKIAIAVRKDVFSREFDPGIVESFNERFEAIKSNNPKPPARKKGFRKKRK
>Mature_370_residues
MKCYLTGCIAGPLAFSEDLELIDYEPFPVDEIPGRLAESQMGGVSPEERIMLERLTPEYDEVVVEASPSPEYAGFRNLRF
EVPSRAGIHLRENLEDILAEILDMPAGDFIHDALMSVARERLRESLRETDRFIIQSINALDELDEETGKLIERLREWYSL
HFPELDGIKSHEQYVELIAEYGDRDQILKNFRMDVDESLGSDITSEDLHILRGLAESIRGLQRLREETERYIDIKMEKLA
PNLRALAGSNVGARLIAHAGGLRELAMLPSSTIQVLGAEKALFRHLKSGAKPPKHGVIFQHPSIRSSPWWIRGKVARLLA
GKIAIAVRKDVFSREFDPGIVESFNERFEAIKSNNPKPPARKKGFRKKRK

Specific function: Unknown

COG id: COG1498

COG function: function code J; Protein implicated in ribosomal biogenesis, Nop56p homolog

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Nop domain [H]

Homologues:

Organism=Homo sapiens, GI32483374, Length=345, Percent_Identity=32.7536231884058, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI7706254, Length=231, Percent_Identity=36.7965367965368, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI221136939, Length=223, Percent_Identity=26.9058295964126, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509449, Length=297, Percent_Identity=35.6902356902357, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562296, Length=353, Percent_Identity=31.1614730878187, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17510923, Length=271, Percent_Identity=25.4612546125461, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324886, Length=236, Percent_Identity=38.5593220338983, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323226, Length=264, Percent_Identity=32.1969696969697, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321528, Length=127, Percent_Identity=32.2834645669291, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28572126, Length=235, Percent_Identity=37.8723404255319, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17137636, Length=234, Percent_Identity=38.8888888888889, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI21357435, Length=337, Percent_Identity=24.9258160237389, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012976
- InterPro:   IPR002687 [H]

Pfam domain/function: PF01798 Nop; PF08060 NOSIC [H]

EC number: NA

Molecular weight: Translated: 42008; Mature: 42008

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCYLTGCIAGPLAFSEDLELIDYEPFPVDEIPGRLAESQMGGVSPEERIMLERLTPEYD
CCEEEEEHHHCCCCCCCCCCEECCCCCCHHHHCHHHHHHHCCCCCHHHHHHHHHHCCCHH
EVVVEASPSPEYAGFRNLRFEVPSRAGIHLRENLEDILAEILDMPAGDFIHDALMSVARE
HEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLRESLRETDRFIIQSINALDELDEETGKLIERLREWYSLHFPELDGIKSHEQYVELIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
YGDRDQILKNFRMDVDESLGSDITSEDLHILRGLAESIRGLQRLREETERYIDIKMEKLA
HCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNLRALAGSNVGARLIAHAGGLRELAMLPSSTIQVLGAEKALFRHLKSGAKPPKHGVIFQ
CHHHHHHCCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
HPSIRSSPWWIRGKVARLLAGKIAIAVRKDVFSREFDPGIVESFNERFEAIKSNNPKPPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCH
RKKGFRKKRK
HHHCHHHCCC
>Mature Secondary Structure
MKCYLTGCIAGPLAFSEDLELIDYEPFPVDEIPGRLAESQMGGVSPEERIMLERLTPEYD
CCEEEEEHHHCCCCCCCCCCEECCCCCCHHHHCHHHHHHHCCCCCHHHHHHHHHHCCCHH
EVVVEASPSPEYAGFRNLRFEVPSRAGIHLRENLEDILAEILDMPAGDFIHDALMSVARE
HEEEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RLRESLRETDRFIIQSINALDELDEETGKLIERLREWYSLHFPELDGIKSHEQYVELIAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
YGDRDQILKNFRMDVDESLGSDITSEDLHILRGLAESIRGLQRLREETERYIDIKMEKLA
HCCHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNLRALAGSNVGARLIAHAGGLRELAMLPSSTIQVLGAEKALFRHLKSGAKPPKHGVIFQ
CHHHHHHCCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
HPSIRSSPWWIRGKVARLLAGKIAIAVRKDVFSREFDPGIVESFNERFEAIKSNNPKPPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCH
RKKGFRKKRK
HHHCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]