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Identifier: 15679026

GI number: 15679026

Start: 921390

End: 922451

Strand: Direct

Name: Not Available

Synonym: MTH1008

Alternate gene names: 15679026

Gene position: 921390-922451 (Clockwise)

Preceding gene: 15679025

Following gene: 15679027

Centisome position: 52.61

GC content: 50.19

Gene sequence:

>1062_bases
ATGAATAGAAGGGAAATAGCCATTAACAAACTCAAAAGTCTTGGAGACGTTATACTCGATGATGTGACCCAGGGGAGAAT
CCCCAGGATAAAGGTTCCATCAAGGGGCACATCCAACATAATCTATGATGAAGATAAGAGGCACTACGTCCTCGGAGACC
GATACGGTACACGTTCAATGGGTAACGTTAAGCAGATCAAGAAGATAGGGCAGATGCTCTACACAGCCAACTTCTGCAAG
GACCTCGTGGCGAGGGAGAAAACAGCCACCCTCAGGGAACTCTACTACATCTCAGAGGGTTGGGAGGTGGACTTTGCAGA
CCAGCAGGAGTCCAACATCGTTGGTGAGGACCTTGAGGTCACCCTGGGCATGACCAGGGAGGAACTGGGCCTCATGCCAG
AGGAGGACGGAGCGTCCGTCTACGGGGCCCTGACTGTCCGTGAGGGTGATATTGAAATAGACGCCCTCCGATCAGGTAAA
TCAGGCTACAACATATCCCCAACCATCGATGAGGTTGAATTTGTGGACCATGACGTTGAACGTGTCATTGCAGTTGAGAC
AATGGGTATGTTCCACCGTCTCGTTCAGGAGAAGGCCTACAAGAAGTTTGATGCCCTCATAGTCGGACTGAAGGGTCAGG
CTGCAAGGGCAACAAGGAGGTTCATCAAGAGGGTCAACGAGGAACTCAACCTCCCGGTTTACATCTGCAACGACGGAGAC
CCATGGGGATTCCATATCGCCATGGTCATAATCTCAGGCAGTGCAAAACTCGCCCATGTGAACCATCAGCTTGCAACCCC
GGATGCAAAGTTCCTGGGTGTGACTGCAAGTGACATAATAAACTATGACCTTCCAACTGATCCTCTCAAGGATGTCGATG
TTGTAAGGCTCAAGGAGCTCCTCCAAGACCCCAGATACAGGGGTGATTTCTGGAAGACAGAAATCAAGAAGATGCTCACC
ATCGGTAAGAAGGCAGAACAGCAGTCCTTCTCAAAGTATGGTCTTGAGTATGTTGTAGATACCTATCTGCCAGAGAAACT
CGAGGCTGTGGAGAACCAGTAG

Upstream 100 bases:

>100_bases
AGGCCGCTCTCCTGGCTGAGCGGGAAGAACCCGATTACAGAGAACTGCTCGACACAGTTACAAGAAGGGCAAAACTTGAA
ATTCTGGGGGGAATCACTGA

Downstream 100 bases:

>100_bases
CTGAAGCATCTTAAATTTTTATTTTTTAGACACAATCTTTTTTTCAAGAAAAAACTGATCGCTGCTAACCAGCTTTTATT
TTAGACACATAATCTTTTTT

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSMGNVKQIKKIGQMLYTANFCK
DLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEVTLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGK
SGYNISPTIDEVEFVDHDVERVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGD
PWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKELLQDPRYRGDFWKTEIKKMLT
IGKKAEQQSFSKYGLEYVVDTYLPEKLEAVENQ

Sequences:

>Translated_353_residues
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSMGNVKQIKKIGQMLYTANFCK
DLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEVTLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGK
SGYNISPTIDEVEFVDHDVERVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGD
PWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKELLQDPRYRGDFWKTEIKKMLT
IGKKAEQQSFSKYGLEYVVDTYLPEKLEAVENQ
>Mature_353_residues
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSMGNVKQIKKIGQMLYTANFCK
DLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEVTLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGK
SGYNISPTIDEVEFVDHDVERVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGD
PWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKELLQDPRYRGDFWKTEIKKMLT
IGKKAEQQSFSKYGLEYVVDTYLPEKLEAVENQ

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family

Homologues:

Organism=Homo sapiens, GI6912680, Length=348, Percent_Identity=24.7126436781609, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI38201680, Length=296, Percent_Identity=26.0135135135135, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552753, Length=341, Percent_Identity=25.5131964809384, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOP6A_METTH (O27089)

Other databases:

- EMBL:   AE000666
- PIR:   D69001
- RefSeq:   NP_276143.1
- ProteinModelPortal:   O27089
- SMR:   O27089
- STRING:   O27089
- GeneID:   1471416
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1008
- NMPDR:   fig|187420.1.peg.998
- eggNOG:   arNOG04570
- HOGENOM:   HBG559107
- OMA:   DGDPYGW
- ProtClustDB:   PRK04342
- BioCyc:   MTHE187420:MTH1008-MONOMER
- BRENDA:   5.99.1.3
- GO:   GO:0005694
- HAMAP:   MF_00132
- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10848
- PRINTS:   PR01550
- PRINTS:   PR01552

Pfam domain/function: PF04406 TP6A_N; SSF56726 Spo11/TopoVI_A

EC number: =5.99.1.3

Molecular weight: Translated: 40029; Mature: 40029

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: ACT_SITE 96-96

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSM
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCEEEECCCCCCCCC
GNVKQIKKIGQMLYTANFCKDLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCCCCCCCCCCCEEE
TLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGKSGYNISPTIDEVEFVDHDVE
EECCCHHHHCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
RVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGD
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
PWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKEL
CCCEEEEEEEEECCCEEEECCCCCCCCCCCEEECCHHHHEECCCCCCCCCCCHHHHHHHH
LQDPRYRGDFWKTEIKKMLTIGKKAEQQSFSKYGLEYVVDTYLPEKLEAVENQ
HHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure
MNRREIAINKLKSLGDVILDDVTQGRIPRIKVPSRGTSNIIYDEDKRHYVLGDRYGTRSM
CCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCEEEECCCCCCCCC
GNVKQIKKIGQMLYTANFCKDLVAREKTATLRELYYISEGWEVDFADQQESNIVGEDLEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCCCCCCCCCCCEEE
TLGMTREELGLMPEEDGASVYGALTVREGDIEIDALRSGKSGYNISPTIDEVEFVDHDVE
EECCCHHHHCCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
RVIAVETMGMFHRLVQEKAYKKFDALIVGLKGQAARATRRFIKRVNEELNLPVYICNDGD
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
PWGFHIAMVIISGSAKLAHVNHQLATPDAKFLGVTASDIINYDLPTDPLKDVDVVRLKEL
CCCEEEEEEEEECCCEEEECCCCCCCCCCCEEECCHHHHEECCCCCCCCCCCHHHHHHHH
LQDPRYRGDFWKTEIKKMLTIGKKAEQQSFSKYGLEYVVDTYLPEKLEAVENQ
HHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463