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Identifier: 15679025

GI number: 15679025

Start: 919822

End: 921393

Strand: Direct

Name: Not Available

Synonym: MTH1007

Alternate gene names: 15679025

Gene position: 919822-921393 (Clockwise)

Preceding gene: 15679024

Following gene: 15679026

Centisome position: 52.52

GC content: 50.83

Gene sequence:

>1572_bases
TTGGCGAGGCAAGCTTTGGATCTCTTTGATGAAGGATTCCAGGAACTCACTCCATCAGAATTCTTCAGAAAAAACAAGCA
GATGCTTGGTTTTACCGGGAAAATAAGGTCACTTACAATAGTGTTCCATGAACTCATAACCAACAGCTTTGACGCTGCCG
AAGAGGCAGGTATACTCCCTGAGATCAAAATAGATCTCAAGAGAATCGGGAAGGACCATTACATCCTGAGACACCAGGAC
AACGGCCCGGGTATACCTGAAAAGTACATCCCAAAGGTCTTCTGTACCATGTTCGCAGGGTCAAAGTTCAGGAACATCCA
GTCCAGGGGACAGCAGGGACTCGGATGCAGTGGCTGTGTGCTGCTATCACAGATGACCACAGGTAAACCCGTGAAGGTCA
TCTCAGGTACAATGGAAAACGGGGAACTCAAGGGGGTCAAAATGACCCTCAAGATGGATGTTAAAAAGAACCAGGGCCTC
ATACTCGAAAAGGAGGAAGTCGAAGTCGATGGTACCGGTGTCTGCATAGAACTCCACTTCAAGGACGTCTCCTACTCACT
CTCAGAACAGGGAGCCTACGAGTACATAAGGAGGACAATGATAGCCAACCCCCATGCCAGGATAGTATTCAATGACCCAA
CCGGAAACCGTTACGTCTTCAACAGGGCATCCGACGTCATACCCCCAATGCCAAAGGAGGTCCTCCCCCACCCATGGGGT
GTCACCGCCGATGACCTTATATTCATGGCAAAGCACACCGATAAAAGGCGGTTCGGGAGCATGCTGAAAAGCAACCTCTC
AAGGATGTCCTCCATGAAGATCAAGGAACTGGAGGAACTGACAGGGATAGACCTCAACAAAAGACCGAAGGACATGAAGT
GGGAGGAGGCCGAGCAGATAGTTGAGGCCTTCAAGAAGATGAAATTCATGTCACCCCCGACCTCCGGCCTCATACCCATC
GGAGAGGAGCAGATTGATAAGGGTATGAAGGAGATACTCCAGCCAGAGTTCACAGCAACGGTAACAAGGAAGCCAAAAAC
CTACCGTGGGGGTATAGCCTTCATAGTTGAGGCAGGTATCGCCTACGGTGGAAACTCCGGCAGACTGGTCGGTGACCAGA
GAAAGGCTGAGATAATGAGGTTCGCCAACAGGGTACCCCTCACCTTCGACGCCGGAAGCTGTGCCATAACAGAGGGTGTT
AAGAGCCTCGACTGGAAGCGTTACGGCATAAGGGACCTTGAAAATGCACCCATAAGCATATTCGTCAATGTGGTGTCAAC
CAACGTCCCCTACCTGTCAACGGGTAAGCAGAGTGTGTCACCTGAACCCGAGATACTCGGGGAGATCAGGCAGGCCACCA
TGATAGTTGCAAGGAAGCTCCACAAGTACCTCAGGAAGAAGAAGGCAGCCAAGGAGGAGGCGCAGAGGGCGAAGATCTTT
GAGAGCTACGTGCCTGTGATCATAAAACAGGCCGCTCTCCTGGCTGAGCGGGAAGAACCCGATTACAGAGAACTGCTCGA
CACAGTTACAAGAAGGGCAAAACTTGAAATTCTGGGGGGAATCACTGAATGA

Upstream 100 bases:

>100_bases
AGGGTATAAGTTTATATGGCATGAATTACACATATATCCATATGAACATGGCAGTCCCCATGTATTAATCCCATGAAAAA
TTTTTAAAGGAGGCGAATTT

Downstream 100 bases:

>100_bases
ATAGAAGGGAAATAGCCATTAACAAACTCAAAAGTCTTGGAGACGTTATACTCGATGATGTGACCCAGGGGAGAATCCCC
AGGATAAAGGTTCCATCAAG

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILPEIKIDLKRIGKDHYILRHQD
NGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGL
ILEKEEVEVDGTGVCIELHFKDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWG
VTADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQIVEAFKKMKFMSPPTSGLIPI
GEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGIAYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGV
KSLDWKRYGIRDLENAPISIFVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIF
ESYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE

Sequences:

>Translated_523_residues
MARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILPEIKIDLKRIGKDHYILRHQD
NGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGL
ILEKEEVEVDGTGVCIELHFKDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWG
VTADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQIVEAFKKMKFMSPPTSGLIPI
GEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGIAYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGV
KSLDWKRYGIRDLENAPISIFVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIF
ESYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE
>Mature_522_residues
ARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILPEIKIDLKRIGKDHYILRHQDN
GPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGLI
LEKEEVEVDGTGVCIELHFKDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWGV
TADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQIVEAFKKMKFMSPPTSGLIPIG
EEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGIAYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGVK
SLDWKRYGIRDLENAPISIFVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIFE
SYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOP6B_METTH (O27088)

Other databases:

- EMBL:   AE000666
- PIR:   C69001
- RefSeq:   NP_276142.1
- ProteinModelPortal:   O27088
- STRING:   O27088
- GeneID:   1471415
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1007
- NMPDR:   fig|187420.1.peg.997
- eggNOG:   arNOG04571
- HOGENOM:   HBG733142
- OMA:   PYASAGK
- ProtClustDB:   PRK04184
- BioCyc:   MTHE187420:MTH1007-MONOMER
- BRENDA:   5.99.1.3
- GO:   GO:0005694
- HAMAP:   MF_00322
- InterPro:   IPR003594
- InterPro:   IPR010979
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF006553
- ProDom:   PD013790
- SMART:   SM00387
- TIGRFAMs:   TIGR01052

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans; SSF55874 ATP_bd_ATPase; SSF46946 Ribosomal_H2TH; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =5.99.1.3

Molecular weight: Translated: 58859; Mature: 58728

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILP
CCCHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCC
EIKIDLKRIGKDHYILRHQDNGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCV
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
LLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGLILEKEEVEVDGTGVCIELHF
HHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEECCCEEECCCEEEEEEEE
KDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWG
ECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHCCCCCC
VTADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQI
CCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
VEAFKKMKFMSPPTSGLIPIGEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCH
AYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGVKSLDWKRYGIRDLENAPISI
HCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHCCCCCCCCCCEEE
FVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIF
EEEEHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARQALDLFDEGFQELTPSEFFRKNKQMLGFTGKIRSLTIVFHELITNSFDAAEEAGILP
CCHHHHHHHHHHHHCCHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCC
EIKIDLKRIGKDHYILRHQDNGPGIPEKYIPKVFCTMFAGSKFRNIQSRGQQGLGCSGCV
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHH
LLSQMTTGKPVKVISGTMENGELKGVKMTLKMDVKKNQGLILEKEEVEVDGTGVCIELHF
HHHHHCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEECCCEEECCCEEEEEEEE
KDVSYSLSEQGAYEYIRRTMIANPHARIVFNDPTGNRYVFNRASDVIPPMPKEVLPHPWG
ECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCCCCCCHHHCCCCCC
VTADDLIFMAKHTDKRRFGSMLKSNLSRMSSMKIKELEELTGIDLNKRPKDMKWEEAEQI
CCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
VEAFKKMKFMSPPTSGLIPIGEEQIDKGMKEILQPEFTATVTRKPKTYRGGIAFIVEAGI
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCH
AYGGNSGRLVGDQRKAEIMRFANRVPLTFDAGSCAITEGVKSLDWKRYGIRDLENAPISI
HCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHCCCCCCCCCCEEE
FVNVVSTNVPYLSTGKQSVSPEPEILGEIRQATMIVARKLHKYLRKKKAAKEEAQRAKIF
EEEEHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESYVPVIIKQAALLAEREEPDYRELLDTVTRRAKLEILGGITE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463