Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678899

GI number: 15678899

Start: 800264

End: 800938

Strand: Direct

Name: Not Available

Synonym: MTH879

Alternate gene names: 15678899

Gene position: 800264-800938 (Clockwise)

Preceding gene: 15678897

Following gene: 15678900

Centisome position: 45.69

GC content: 53.33

Gene sequence:

>675_bases
ATGAGAATCGTGATTACCATTGGAGGATCAATCATCATAAGTGAATTCTCCCATGAGATGTTCAGGGCCTATGCTGACAT
TCTGAATTCACTGAGAGATGAACATGATCTCTTTGTGGTTGTGGGGGGAGGAAGACCTGCCCGTGACTACATAGGAGTTG
CCAGGGAACTGGGAGCCAGCGAGGCCCGGTGCGATGATATAGGTATTGATGTGACCCGCCTGAATGCCCGGCTCCTTATA
ACCGCCCTGGGTGATAGCGCCTACCCGGGGGTTCCAGAGAACTTCAGGGAGGCCCTCGAGGTTGCTGCGACCGGGAGGAT
AGTCGTGATGGGTGGTACCGAACCAGCCCACAGCACAGATGCTGTCGGGGCAATACTCGCTGAGACCGTTGAGGCGGACC
TCATGATAAACCTCACCTCGGTGGATGGATTCTATGACAGAGACCCGGCCAAATATCCTGACGCCAGGTTCTACCCGGAG
ATCACCGCCAGTGAGATGCTCGAACACCTCAGGGGCTCTGATGTGAGGGCGGGTACCTATGAATTCTTTGACCACACAGC
CCTGCATATGATAAGGAGGTCAGGTATAAGGACCATGATAGTGAACGGTAACGACCCTGAAAATCTCCTGAGAGCCCTTG
ATGGTGAGATAGGCACCACAGTTATCCCTGAATAA

Upstream 100 bases:

>100_bases
GGGGTGATTATAAAGTTTACTGGAGGGTGGGAGAAAAATGTATAAATGGATTCCACCATAACTCGAAAGGAAGAGTCAAC
TGATTTTATGGTGGACCGTT

Downstream 100 bases:

>100_bases
ACCGCTAAATTACTGAGATGTAATCAAAATTTAATGGAGGTAATAGTTATGGTTGAACCACACAAGCACTGCCCTGTATG
CAGTACCCCGATACCCATGG

Product: uridine monophosphate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRIVITIGGSIIISEFSHEMFRAYADILNSLRDEHDLFVVVGGGRPARDYIGVARELGASEARCDDIGIDVTRLNARLLI
TALGDSAYPGVPENFREALEVAATGRIVVMGGTEPAHSTDAVGAILAETVEADLMINLTSVDGFYDRDPAKYPDARFYPE
ITASEMLEHLRGSDVRAGTYEFFDHTALHMIRRSGIRTMIVNGNDPENLLRALDGEIGTTVIPE

Sequences:

>Translated_224_residues
MRIVITIGGSIIISEFSHEMFRAYADILNSLRDEHDLFVVVGGGRPARDYIGVARELGASEARCDDIGIDVTRLNARLLI
TALGDSAYPGVPENFREALEVAATGRIVVMGGTEPAHSTDAVGAILAETVEADLMINLTSVDGFYDRDPAKYPDARFYPE
ITASEMLEHLRGSDVRAGTYEFFDHTALHMIRRSGIRTMIVNGNDPENLLRALDGEIGTTVIPE
>Mature_224_residues
MRIVITIGGSIIISEFSHEMFRAYADILNSLRDEHDLFVVVGGGRPARDYIGVARELGASEARCDDIGIDVTRLNARLLI
TALGDSAYPGVPENFREALEVAATGRIVVMGGTEPAHSTDAVGAILAETVEADLMINLTSVDGFYDRDPAKYPDARFYPE
ITASEMLEHLRGSDVRAGTYEFFDHTALHMIRRSGIRTMIVNGNDPENLLRALDGEIGTTVIPE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=200, Percent_Identity=30, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_METTH (O26965)

Other databases:

- EMBL:   AE000666
- PIR:   D69217
- RefSeq:   NP_276016.1
- ProteinModelPortal:   O26965
- SMR:   O26965
- STRING:   O26965
- GeneID:   1471287
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH879
- NMPDR:   fig|187420.1.peg.871
- eggNOG:   arNOG05927
- HOGENOM:   HBG497552
- OMA:   TRANAML
- ProtClustDB:   CLSK798024
- BioCyc:   MTHE187420:MTH879-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24439; Mature: 24439

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: BINDING 43-43 BINDING 44-44 BINDING 48-48 BINDING 65-65 BINDING 139-139 BINDING 145-145 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVITIGGSIIISEFSHEMFRAYADILNSLRDEHDLFVVVGGGRPARDYIGVARELGAS
CEEEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCC
EARCDDIGIDVTRLNARLLITALGDSAYPGVPENFREALEVAATGRIVVMGGTEPAHSTD
CCCCCCCCCEEEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHH
AVGAILAETVEADLMINLTSVDGFYDRDPAKYPDARFYPEITASEMLEHLRGSDVRAGTY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHH
EFFDHTALHMIRRSGIRTMIVNGNDPENLLRALDGEIGTTVIPE
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCEECCC
>Mature Secondary Structure
MRIVITIGGSIIISEFSHEMFRAYADILNSLRDEHDLFVVVGGGRPARDYIGVARELGAS
CEEEEEECCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCC
EARCDDIGIDVTRLNARLLITALGDSAYPGVPENFREALEVAATGRIVVMGGTEPAHSTD
CCCCCCCCCEEEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCHH
AVGAILAETVEADLMINLTSVDGFYDRDPAKYPDARFYPEITASEMLEHLRGSDVRAGTY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHH
EFFDHTALHMIRRSGIRTMIVNGNDPENLLRALDGEIGTTVIPE
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463