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Identifier: 15678840

GI number: 15678840

Start: 743716

End: 744390

Strand: Direct

Name: Not Available

Synonym: MTH818

Alternate gene names: 15678840

Gene position: 743716-744390 (Clockwise)

Preceding gene: 15678839

Following gene: 15678841

Centisome position: 42.46

GC content: 53.93

Gene sequence:

>675_bases
GTGGTTAAAATGAATGTGGAGACAAGGGAGGAACTTGCATCACTTATAGACCACACCAATGTGAGGGCTGATGCAACAGA
AAATGATATTGAGAGGCTATGCAGGGAGGCGGTCAGCTACGGCTTCAGGTGCGCGGTGGTCACACCCACCAATGTCAGGC
TGGCGGCTGAACTCCTTGAGGGGACCGATGTGACGGTCTGCTCAGTTGTTGGTTTCCCGGCAGGCGTCAGTACACCCCGC
GTTAAGGCCCTTGAAGCCTCTGAGGCCGTTGAGAACGGGGCCGGTGAGGTGGACATGGTCATGAATATCGGGGCCATGAA
GTCAGGCAATAGGGAGCTCGTATACAGGGATATCAGCGGCGTTGTTGATGCCGCCGGCGTCCCCGTCAAGGTTATACTTG
AAACAGCCTATCTCACAGACAAGGAGAAGGTTGAAGCCTGCCTTATAAGTAAAGAGGCCGGTGCGGCATTTGTTAAAACA
TCAACAGCCTATGGTGGACTAGCCGGCGCCACAGTTGAGGATGTGATGCTCATGCGGAAAACGGTGGGTGATGAGATGGG
AGTCAAGGCATCTGGGGGAATAAGGGATCTTGAAACAGCCCTTGCGATGATAGATGCTGGGGCAGACAGGATCGGGACAT
CAACCGGTGTACAGATAATCGAGGGATGGAGGTAG

Upstream 100 bases:

>100_bases
AATGGAGAAGATACTTGTAACAAGTGGGATAGGTGCCCGTGAATACTACAGCAAATTCGGATACCTGAAGGAGGGCCCCT
ACATGGCAAAGAAACTTTAG

Downstream 100 bases:

>100_bases
TGGCTGGTGAGGACCATGAGGATAAGGATAACCGTTGAGGGTAAGGGCCATGCCACCGGTGAACTTGATGATAGAAACCC
CGAATCTGCAAGGAGAATCT

Product: deoxyribose-phosphate aldolase

Products: NA

Alternate protein names: Phosphodeoxyriboaldolase; DERA; Deoxyriboaldolase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVKMNVETREELASLIDHTNVRADATENDIERLCREAVSYGFRCAVVTPTNVRLAAELLEGTDVTVCSVVGFPAGVSTPR
VKALEASEAVENGAGEVDMVMNIGAMKSGNRELVYRDISGVVDAAGVPVKVILETAYLTDKEKVEACLISKEAGAAFVKT
STAYGGLAGATVEDVMLMRKTVGDEMGVKASGGIRDLETALAMIDAGADRIGTSTGVQIIEGWR

Sequences:

>Translated_224_residues
MVKMNVETREELASLIDHTNVRADATENDIERLCREAVSYGFRCAVVTPTNVRLAAELLEGTDVTVCSVVGFPAGVSTPR
VKALEASEAVENGAGEVDMVMNIGAMKSGNRELVYRDISGVVDAAGVPVKVILETAYLTDKEKVEACLISKEAGAAFVKT
STAYGGLAGATVEDVMLMRKTVGDEMGVKASGGIRDLETALAMIDAGADRIGTSTGVQIIEGWR
>Mature_224_residues
MVKMNVETREELASLIDHTNVRADATENDIERLCREAVSYGFRCAVVTPTNVRLAAELLEGTDVTVCSVVGFPAGVSTPR
VKALEASEAVENGAGEVDMVMNIGAMKSGNRELVYRDISGVVDAAGVPVKVILETAYLTDKEKVEACLISKEAGAAFVKT
STAYGGLAGATVEDVMLMRKTVGDEMGVKASGGIRDLETALAMIDAGADRIGTSTGVQIIEGWR

Specific function: Nucleotide and deoxyribonucleotide catabolism. [C]

COG id: COG0274

COG function: function code F; Deoxyribose-phosphate aldolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily

Homologues:

Organism=Homo sapiens, GI116063554, Length=228, Percent_Identity=30.7017543859649, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790841, Length=215, Percent_Identity=32.5581395348837, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEOC_METTH (O26909)

Other databases:

- EMBL:   AE000666
- PIR:   C69209
- RefSeq:   NP_275957.1
- ProteinModelPortal:   O26909
- SMR:   O26909
- STRING:   O26909
- GeneID:   1471226
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH818
- NMPDR:   fig|187420.1.peg.812
- eggNOG:   arNOG10952
- HOGENOM:   HBG636421
- OMA:   GANTPEV
- PhylomeDB:   O26909
- ProtClustDB:   CLSK2750427
- BioCyc:   MTHE187420:MTH818-MONOMER
- BRENDA:   4.1.2.4
- GO:   GO:0005737
- HAMAP:   MF_00114
- InterPro:   IPR013785
- InterPro:   IPR011343
- InterPro:   IPR002915
- InterPro:   IPR022979
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR10889
- PIRSF:   PIRSF001357
- TIGRFAMs:   TIGR00126

Pfam domain/function: PF01791 DeoC

EC number: =4.1.2.4

Molecular weight: Translated: 23603; Mature: 23603

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: ACT_SITE 159-159 ACT_SITE 189-189

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMNVETREELASLIDHTNVRADATENDIERLCREAVSYGFRCAVVTPTNVRLAAELLE
CEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHC
GTDVTVCSVVGFPAGVSTPRVKALEASEAVENGAGEVDMVMNIGAMKSGNRELVYRDISG
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEHHHH
VVDAAGVPVKVILETAYLTDKEKVEACLISKEAGAAFVKTSTAYGGLAGATVEDVMLMRK
HHHCCCCCCEEEEHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
TVGDEMGVKASGGIRDLETALAMIDAGADRIGTSTGVQIIEGWR
HHCHHCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCEEECCCC
>Mature Secondary Structure
MVKMNVETREELASLIDHTNVRADATENDIERLCREAVSYGFRCAVVTPTNVRLAAELLE
CEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHC
GTDVTVCSVVGFPAGVSTPRVKALEASEAVENGAGEVDMVMNIGAMKSGNRELVYRDISG
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEHHHH
VVDAAGVPVKVILETAYLTDKEKVEACLISKEAGAAFVKTSTAYGGLAGATVEDVMLMRK
HHHCCCCCCEEEEHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
TVGDEMGVKASGGIRDLETALAMIDAGADRIGTSTGVQIIEGWR
HHCHHCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463