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Identifier: 15678630

GI number: 15678630

Start: 539006

End: 539740

Strand: Direct

Name: Not Available

Synonym: MTH602

Alternate gene names: 15678630

Gene position: 539006-539740 (Clockwise)

Preceding gene: 15678629

Following gene: 15678632

Centisome position: 30.78

GC content: 52.79

Gene sequence:

>735_bases
ATGGGGGCAGGGCCAGGAGACCCTGAACTCATAACACTGAAAGCTGTGCGCGCCCTCAGAGGGGCTGATGTTGTAATATA
CGCAGGTTCACTTGTAAACAGGGATATACTTGAATATGCGCCTGAAGATGCGGAGGTCCACAACAGCGCACACATGAACC
TGGAGGAGATAACAGATATAATGGTGGAGGCCTGCAGGGCAGGTAAGACCGTTGCAAGGGTTCACACCGGTGACCCCTCA
ATCTACGGAGCCATAAAGGAACAGATAAGGGTTCTCGAGAAAAACAGCATACCCTACACCATCATACCGGGTGTGAGTTC
TGTCTTTGCAGCTGCAGCCACACTGAACACTGAGCTGACCCTCCCTGAGGTCTCCCAGACTGTCATAATAACAAGGCCCG
CTGGAAGGACACCGGTACCTCCAGGTGAGGATCTTGAGGAGCTTGCAGTCCACGGGTCAACCATGTGCATCTTCCTGGGT
GTTCATATGATAGAGGATGTTGCAGAAAAACTCATGACCCACTACCCGCCGGATACCCCTGTGGCCGTTGTTAAGAGGGC
ATCCTGGCCGGATGAAGAGGTTGTGAGGGGCACACTGTCGGATATAGCTGAAAGGGTGAGGGCTGCCGGTATAAGTAAGA
CAGCCATGATCATTGTGGGGAGTGTGCTTGAACCAGGAGACTTCAAACCATCGAAACTCTATGACGCCGGATTCAGCCAT
GAATACCGGCCCTGA

Upstream 100 bases:

>100_bases
AGGGCCATAAAAATGATGGGCCCCGGAAAAAAGATAATCAGGGGATGATAATCTGAGTGGAAAGGAAACTCGAGATAATA
AAACAGGAAGTGTCATATTC

Downstream 100 bases:

>100_bases
AAATCCTCCTTTAGATCAGAAAAAATATCTGTGAAATATTTAGATGCTCAAAAAAGCTGAATAATCCGGACATCAGAAGG
TAACAAGCTTTATGTGTTTC

Product: precorrin-3 methylase

Products: S-adenosyl-L-homocysteine; Precorrin 5

Alternate protein names: Cobalt-precorrin-3 methylase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MGAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDIMVEACRAGKTVARVHTGDPS
IYGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELTLPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLG
VHMIEDVAEKLMTHYPPDTPVAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSKLYDAGFSH
EYRP

Sequences:

>Translated_244_residues
MGAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDIMVEACRAGKTVARVHTGDPS
IYGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELTLPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLG
VHMIEDVAEKLMTHYPPDTPVAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSKLYDAGFSH
EYRP
>Mature_243_residues
GAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDIMVEACRAGKTVARVHTGDPSI
YGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELTLPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLGV
HMIEDVAEKLMTHYPPDTPVAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSKLYDAGFSHE
YRP

Specific function: Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=231, Percent_Identity=32.034632034632, Blast_Score=111, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322922, Length=231, Percent_Identity=25.974025974026, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: 2.1.1.133

Molecular weight: Translated: 26250; Mature: 26119

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDI
CCCCCCCCCEEEHHHHHHHCCCCEEEEECCHHCCHHHHHCCCCHHHCCCCCCCHHHHHHH
MVEACRAGKTVARVHTGDPSIYGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELT
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCC
LPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLGVHMIEDVAEKLMTHYPPDTP
CCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
VAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSKLYDAGFSH
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCCHHHHCCCCCC
EYRP
CCCC
>Mature Secondary Structure 
GAGPGDPELITLKAVRALRGADVVIYAGSLVNRDILEYAPEDAEVHNSAHMNLEEITDI
CCCCCCCCEEEHHHHHHHCCCCEEEEECCHHCCHHHHHCCCCHHHCCCCCCCHHHHHHH
MVEACRAGKTVARVHTGDPSIYGAIKEQIRVLEKNSIPYTIIPGVSSVFAAAATLNTELT
HHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCC
LPEVSQTVIITRPAGRTPVPPGEDLEELAVHGSTMCIFLGVHMIEDVAEKLMTHYPPDTP
CCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
VAVVKRASWPDEEVVRGTLSDIAERVRAAGISKTAMIIVGSVLEPGDFKPSKLYDAGFSH
HHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCCHHHHCCCCCC
EYRP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; Precorrin 4

Specific reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]