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Identifier: 15678629

GI number: 15678629

Start: 538064

End: 538915

Strand: Direct

Name: Not Available

Synonym: MTH601

Alternate gene names: NA

Gene position: 538064-538915 (Clockwise)

Preceding gene: 15678628

Following gene: 15678630

Centisome position: 30.72

GC content: 56.46

Gene sequence:

>852_bases
ATGATGAGGATCATAATGGTAACCGCAGGGAATTACGGTGCCAGGGTAGTTAACACCATGGCAGTTCACGGCCTCGCCCC
ACAGATTGTGGCCGTCTTCGACTACACAGGGGAGGGCGGGGATTTCCTCGATGACCCATCATCCCTCCTCCCGGCCAGGA
CCCCTGATGCAGATCTAACCGTTGCAGCTGGACTTGGGGGTGACCTGAACCTTGTTGCAGCTGAGATAGCAGCTGAATCA
GGGTCAGGAGGTATCATAGTGGAATCACATGCCCCTGGCCAGCTACCTGATGGTCTGAGATCAGAGATAGACTCCCTGGT
GGATTGTGCGATCTTCCCCACACCCTTCTGTTCCCTTGAACCCGTCGGGAACCCCCACATCGATGCCTTCGCATCCAGGT
TCGGTAAACCTGAAGTTGAAATGGAGGGGAATGAAAGGGTGGTGTCGGTGAAGGTTAAAAGAAGCGCACCCTGCGGCTCC
ACCTTCTATGTTGCAGAGAACATAAGGGGGGTCCCCCTGGATGAGGTGGACGTGGCTGCAGGTGAAAAATTCCATAATTA
CCCCTGCCTGGCATCCATGGAGGTGGATCCACGCTTCGGGGATACACATCTACATGTGGCAGGTTACCTCACAAGGGAGG
CCTTCAAGAGGGCCGCAGGGGTGCCGGGTGCCCATGCAGAGGTTGATCCCGAGGTCTGCAGGGGAGCTGAATGCGGATTC
ATCTGCATGGATGTTTGCCCCCTCGTGAGGTTATCCAGGGGGACGATAAGGAGGGGTGTGACCGCAGAGGTTGACCCATT
CTCCTGCGGTGCCTGTGAGAAGTGCATGAGGGAATGCCCCTCAGGGCCATAA

Upstream 100 bases:

>100_bases
ATAATCTTTGGAAGCGACAGAAACATGGCAATAACCGGCGTGGTCCTGGCACTGATCCTCATGGTCGTGGCCTATCTCCT
CTTCTACAGGTAGAGGTATC

Downstream 100 bases:

>100_bases
AAATGATGGGCCCCGGAAAAAAGATAATCAGGGGATGATAATCTGAGTGGAAAGGAAACTCGAGATAATAAAACAGGAAG
TGTCATATTCATGGGGGCAG

Product: hypothetical protein

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MMRIIMVTAGNYGARVVNTMAVHGLAPQIVAVFDYTGEGGDFLDDPSSLLPARTPDADLTVAAGLGGDLNLVAAEIAAES
GSGGIIVESHAPGQLPDGLRSEIDSLVDCAIFPTPFCSLEPVGNPHIDAFASRFGKPEVEMEGNERVVSVKVKRSAPCGS
TFYVAENIRGVPLDEVDVAAGEKFHNYPCLASMEVDPRFGDTHLHVAGYLTREAFKRAAGVPGAHAEVDPEVCRGAECGF
ICMDVCPLVRLSRGTIRRGVTAEVDPFSCGACEKCMRECPSGP

Sequences:

>Translated_283_residues
MMRIIMVTAGNYGARVVNTMAVHGLAPQIVAVFDYTGEGGDFLDDPSSLLPARTPDADLTVAAGLGGDLNLVAAEIAAES
GSGGIIVESHAPGQLPDGLRSEIDSLVDCAIFPTPFCSLEPVGNPHIDAFASRFGKPEVEMEGNERVVSVKVKRSAPCGS
TFYVAENIRGVPLDEVDVAAGEKFHNYPCLASMEVDPRFGDTHLHVAGYLTREAFKRAAGVPGAHAEVDPEVCRGAECGF
ICMDVCPLVRLSRGTIRRGVTAEVDPFSCGACEKCMRECPSGP
>Mature_283_residues
MMRIIMVTAGNYGARVVNTMAVHGLAPQIVAVFDYTGEGGDFLDDPSSLLPARTPDADLTVAAGLGGDLNLVAAEIAAES
GSGGIIVESHAPGQLPDGLRSEIDSLVDCAIFPTPFCSLEPVGNPHIDAFASRFGKPEVEMEGNERVVSVKVKRSAPCGS
TFYVAENIRGVPLDEVDVAAGEKFHNYPCLASMEVDPRFGDTHLHVAGYLTREAFKRAAGVPGAHAEVDPEVCRGAECGF
ICMDVCPLVRLSRGTIRRGVTAEVDPFSCGACEKCMRECPSGP

Specific function: Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i.e. a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2.1.1.45). However, M.jannaschii like most methanogenic Archaea lacks

COG id: COG1810

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003745 [H]

Pfam domain/function: PF02593 DUF166 [H]

EC number: NA

Molecular weight: Translated: 29839; Mature: 29839

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRIIMVTAGNYGARVVNTMAVHGLAPQIVAVFDYTGEGGDFLDDPSSLLPARTPDADLT
CEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCEE
VAAGLGGDLNLVAAEIAAESGSGGIIVESHAPGQLPDGLRSEIDSLVDCAIFPTPFCSLE
EEECCCCCCEEEEEEEHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PVGNPHIDAFASRFGKPEVEMEGNERVVSVKVKRSAPCGSTFYVAENIRGVPLDEVDVAA
CCCCCCHHHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHC
GEKFHNYPCLASMEVDPRFGDTHLHVAGYLTREAFKRAAGVPGAHAEVDPEVCRGAECGF
CCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCE
ICMDVCPLVRLSRGTIRRGVTAEVDPFSCGACEKCMRECPSGP
EHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MMRIIMVTAGNYGARVVNTMAVHGLAPQIVAVFDYTGEGGDFLDDPSSLLPARTPDADLT
CEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHCCCCCCCCCEE
VAAGLGGDLNLVAAEIAAESGSGGIIVESHAPGQLPDGLRSEIDSLVDCAIFPTPFCSLE
EEECCCCCCEEEEEEEHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PVGNPHIDAFASRFGKPEVEMEGNERVVSVKVKRSAPCGSTFYVAENIRGVPLDEVDVAA
CCCCCCHHHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHC
GEKFHNYPCLASMEVDPRFGDTHLHVAGYLTREAFKRAAGVPGAHAEVDPEVCRGAECGF
CCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCE
ICMDVCPLVRLSRGTIRRGVTAEVDPFSCGACEKCMRECPSGP
EHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]