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Identifier: 15678563

GI number: 15678563

Start: 478303

End: 478812

Strand: Direct

Name: Not Available

Synonym: MTH535

Alternate gene names: 15678563

Gene position: 478303-478812 (Clockwise)

Preceding gene: 15678562

Following gene: 15678564

Centisome position: 27.31

GC content: 54.31

Gene sequence:

>510_bases
GTGATGTGTTTGAGCAGATATGAGAAGGCGACCTTCGGGGCCGGATGCTTCTGGGGGGTCGAGGACGCCTTCAGAAAGGT
TGATGGTGTTGTATCAACCCGTGTGGGATACATGGGGGGTCACCTTGAGAACCCCACATATGAGGATGTCTGCACCGGTC
TTACAGGACACGCAGAGGTGGTTGAGGTAACCTTTGACCCTGATGTTGTGGGTTACAGCGACCTCCTTGATGTGTTCTGG
AGCATACATGACCCGACGACCCTCAACAGGCAGGGCCCGGATGTGGGAGAGCAGTACCGCTCGGTCATATTCTACCACAG
CGATGAGCAGCGAAGGGCTGCCATTGAGTCAAGAAGGAGACTTGAGGAGTCTGGAAGGTTCAGAGACAGGATAGTTACAG
CCATTGAACCAGCAGGGACCTTTTATGAGGCCGAGGAGTACCACCAGCAGTACCTTGAGAAGAACCCCCGGAGGAGATGC
TACCTCATGAGACTACTCTCAACGAGGTGA

Upstream 100 bases:

>100_bases
GCGACCAGGTCAAGGTGAGGGGAAACGTGTCAGGATGAGCACCTAAACTGAAAACCCATGGCTAAATGCCGCGGGGAATC
AGGATGAAAACCTTCAAGGG

Downstream 100 bases:

>100_bases
TCCAGTGAAGATCAATGATGATGCTTCAATCGTCCTCTGCGGTGAGGCAGGGCAGGGCATACAGACCGTCGAGGCCCTCC
TCATAAGGCCTTCAAGGCCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MMCLSRYEKATFGAGCFWGVEDAFRKVDGVVSTRVGYMGGHLENPTYEDVCTGLTGHAEVVEVTFDPDVVGYSDLLDVFW
SIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRRLEESGRFRDRIVTAIEPAGTFYEAEEYHQQYLEKNPRRRC
YLMRLLSTR

Sequences:

>Translated_169_residues
MMCLSRYEKATFGAGCFWGVEDAFRKVDGVVSTRVGYMGGHLENPTYEDVCTGLTGHAEVVEVTFDPDVVGYSDLLDVFW
SIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRRLEESGRFRDRIVTAIEPAGTFYEAEEYHQQYLEKNPRRRC
YLMRLLSTR
>Mature_169_residues
MMCLSRYEKATFGAGCFWGVEDAFRKVDGVVSTRVGYMGGHLENPTYEDVCTGLTGHAEVVEVTFDPDVVGYSDLLDVFW
SIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRRLEESGRFRDRIVTAIEPAGTFYEAEEYHQQYLEKNPRRRC
YLMRLLSTR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=49.0445859872611, Blast_Score=151, Evalue=3e-37,
Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=49.0445859872611, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=48.1818181818182, Blast_Score=98, Evalue=4e-21,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=50.6578947368421, Blast_Score=148, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17533973, Length=166, Percent_Identity=39.1566265060241, Blast_Score=119, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=44.5161290322581, Blast_Score=132, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=41.7808219178082, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664631, Length=146, Percent_Identity=41.0958904109589, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=40.4255319148936, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_METTH (O26635)

Other databases:

- EMBL:   AE000666
- PIR:   F69170
- RefSeq:   NP_275678.1
- ProteinModelPortal:   O26635
- SMR:   O26635
- STRING:   O26635
- GeneID:   1470496
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH535
- NMPDR:   fig|187420.1.peg.533
- eggNOG:   arNOG08844
- HOGENOM:   HBG748152
- OMA:   YHQQYFE
- PhylomeDB:   O26635
- ProtClustDB:   PRK14054
- BioCyc:   MTHE187420:MTH535-MONOMER
- BRENDA:   1.8.4.11
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19548; Mature: 19548

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: ACT_SITE 16-16

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMCLSRYEKATFGAGCFWGVEDAFRKVDGVVSTRVGYMGGHLENPTYEDVCTGLTGHAEV
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEE
VEVTFDPDVVGYSDLLDVFWSIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRR
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHH
LEESGRFRDRIVTAIEPAGTFYEAEEYHQQYLEKNPRRRCYLMRLLSTR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MMCLSRYEKATFGAGCFWGVEDAFRKVDGVVSTRVGYMGGHLENPTYEDVCTGLTGHAEV
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEE
VEVTFDPDVVGYSDLLDVFWSIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRR
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEEEECCHHHHHHHHHHHH
LEESGRFRDRIVTAIEPAGTFYEAEEYHQQYLEKNPRRRCYLMRLLSTR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463