Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678470

GI number: 15678470

Start: 376906

End: 378846

Strand: Direct

Name: Not Available

Synonym: MTH442

Alternate gene names: 15678470

Gene position: 376906-378846 (Clockwise)

Preceding gene: 15678465

Following gene: 15678471

Centisome position: 21.52

GC content: 54.61

Gene sequence:

>1941_bases
GTGATGAAGTTTAAACTGGTATCAGATTACAGACCCCTCGGGGATCAGCCAAAGGCGATAAGGTCCCTTGTTAACGGTAT
AAAGGCCGGGATGAGGGAGCAGACACTCCTGGGGGTCACGGGTTCAGGTAAGACCTTCACAGTGGCCAATGTGATCGCAG
AGGTCCAGAAGCCGACGCTGGTAATATCACACAACAAGACCCTGGCTGCGCAGCTCTATGAGGAGTTCAGGGAGTTCTTC
CCTGAGAACGCCGTGGAGTACTTCGTGAGTTACTATGATTTCTACCAGCCAGAGGCATACATACCCCAGACAGACACCTA
CATAGACAAGGAGGCATCCATAAACGACGAGATAGACCGGATGAGGCACTCGGCAACCCAGTCCCTCCTCTCCAGGGACG
ACGTCATCGTGGTATCCAGTGTCTCCTGCATCTACGGTATAGGTGCACCGACAGACTACGGTGAATTCACCCTCCACCTC
GAGGTCGGATCCGGCCCCGGCAGGGAGGAGGTGCTGGAGGGCCTCATAAACATGCAGTATGAGCGAAACGATGTCGAATT
CGACAGGGGACAGTTCAGGGTCAGGGGTGACACCGTAGAGATCAACCCCATCCATGGAACACCCCCCATAAGGATAGAAT
TCTTCGGCGACGAGATAGACTCCATATCAACGGTTCACAGGGTCACCGGCAGGAGGATACAGAAACTGGACCGTGTAACC
ATATTCCCGGCCAAGCACTTCGTGATACCCGAGGACAGGCTCCAGAGGGCGATAGAGTCAATAGAGGCTGAACTTGAGGA
GAGATTAACTGAACTTAGATCCCAGAACAAACTTCTGGAGGCCCAGAGGCTCGAACAGAGGACAAGGTTCGACATGGAGA
TGCTTAGGGAGATGGGCTACTGCCAGGGCATAGAGAACTACTCAATGCACCTCAGCGGCAGGAAGTGGGGTGAGAAACCA
AACACGCTCCTGGACTACTTCCCTGAGGACTTCCTCACAGTCATCGACGAATCCCATGTGACGGTACCCCAGATAAGGGG
CATGTACAACGGTGACCGGGCAAGGAAGGACACCCTGGTGGAGTACGGCTTCAGACTACCCAGTGCCCGGGAGAACAGGC
CCCTCCGTTTCGACGAGTTCCAGGAGAGCGTGAACCAGGTGATCTATGTCTCTGCAACTCCTGGAAGGTATGAACTCTCA
AGGAGCCAGAACATCGTTGAACAGATCATAAGGCCCACAGGTCTGGTGGACCCTGAGGTCAGGATAAGGCCGGTGAAGGG
CCAGGTGGATGACCTCCTCTCCGAGATAAGGAGGCGGGTTGAGCGGGGTGAGAGGGTCCTTGTAACCACCCTCACAAAGA
GGATGGCCGAGGACCTCACAGACTACTACTCGAGGGTCGGCGTGAAGGTCAGGTACCTCCACTCAGAGATAGACACCCTC
GAGCGTGTTGAGATCATAGACGACCTCAGGAGGGGAGAATTCGACTGCCTGGTGGGTGTTAACCTCCTCAGGGAGGGCCT
CGACCTTCCGGAGGTGGCACTGGTCGCAATACTCGATGCAGACAAGGAGGGCTTCCTGAGGTCAGAGACGTCACTTATAC
AGACAATCGGGAGGGCCGCCAGGAACGTTAACGGTGAGGTGCTCATATACGCCGGCAGGTTCACAGACTCAGTGATGGCG
GCGGTTGAGACAACCAACAGGAGAAGGAAGCTGCAGATGGAGTACAACCGCAGGCATGGTATAAAACCAAGGAGTACAAG
GAGGACCCTCCGGGAAGAAGAAGGACCGTTGAGGAACCTGAAGGTGGATGAGATACCAGACCATGAACTTGAACTCATAA
TAAAGGACCTGGAGGCAGAGATGAGGGACGCTGCAAGGAACCTTGAATTCGAGAGGGCCGCCAGGATCAGGGACAGGATA
ATGTCCCTTAAGAGCAATTAA

Upstream 100 bases:

>100_bases
AGACTCCAGACTCAACTTTATGTATCCTGGCAAAGGTATATATAAGTTGACCCTGAAATATAATCCCACAATAGAATGAG
GTTCTTATTTTAAGTGATTT

Downstream 100 bases:

>100_bases
ACATTTTCTGGTAATGAGAATTAAGGCAGGATTAAAGAGTTTTGGAGACACTGAGGATCATGAGTGGTAAAATAGTCATT
AAGGGTGCCAGGGAGCACAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTLVISHNKTLAAQLYEEFREFF
PENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDRMRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHL
EVGSGPGREEVLEGLINMQYERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVT
IFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGYCQGIENYSMHLSGRKWGEKP
NTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLVEYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELS
RSQNIVEQIIRPTGLVDPEVRIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTL
ERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAARNVNGEVLIYAGRFTDSVMA
AVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNLKVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRI
MSLKSN

Sequences:

>Translated_646_residues
MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTLVISHNKTLAAQLYEEFREFF
PENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDRMRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHL
EVGSGPGREEVLEGLINMQYERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVT
IFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGYCQGIENYSMHLSGRKWGEKP
NTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLVEYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELS
RSQNIVEQIIRPTGLVDPEVRIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTL
ERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAARNVNGEVLIYAGRFTDSVMA
AVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNLKVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRI
MSLKSN
>Mature_646_residues
MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTLVISHNKTLAAQLYEEFREFF
PENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDRMRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHL
EVGSGPGREEVLEGLINMQYERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVT
IFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGYCQGIENYSMHLSGRKWGEKP
NTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLVEYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELS
RSQNIVEQIIRPTGLVDPEVRIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTL
ERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAARNVNGEVLIYAGRFTDSVMA
AVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNLKVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRI
MSLKSN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=57.1644042232277, Blast_Score=727, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_METTH (O26542)

Other databases:

- EMBL:   AE000666
- PIR:   G69157
- RefSeq:   NP_275585.1
- ProteinModelPortal:   O26542
- STRING:   O26542
- GeneID:   1470403
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH442
- NMPDR:   fig|187420.1.peg.440
- eggNOG:   arNOG04992
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   MTHE187420:MTH442-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 74564; Mature: 74564

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHCCCEE
VISHNKTLAAQLYEEFREFFPENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDR
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
MRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHLEVGSGPGREEVLEGLINMQY
HHHHHHHHHHCCCCEEEEECCHHHEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
ERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVT
CCCCCCCCCCEEEEECCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEE
IFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGY
EECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQGIENYSMHLSGRKWGEKPNTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLV
HCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHH
EYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELSRSQNIVEQIIRPTGLVDPEV
HHHCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEHHHHHHHHHHHHCCCCCCCCCC
RIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTL
EEEECCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHH
ERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHH
RNVNGEVLIYAGRFTDSVMAAVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNL
HCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
KVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRIMSLKSN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMKFKLVSDYRPLGDQPKAIRSLVNGIKAGMREQTLLGVTGSGKTFTVANVIAEVQKPTL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHCCCEE
VISHNKTLAAQLYEEFREFFPENAVEYFVSYYDFYQPEAYIPQTDTYIDKEASINDEIDR
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
MRHSATQSLLSRDDVIVVSSVSCIYGIGAPTDYGEFTLHLEVGSGPGREEVLEGLINMQY
HHHHHHHHHHCCCCEEEEECCHHHEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
ERNDVEFDRGQFRVRGDTVEINPIHGTPPIRIEFFGDEIDSISTVHRVTGRRIQKLDRVT
CCCCCCCCCCEEEEECCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEE
IFPAKHFVIPEDRLQRAIESIEAELEERLTELRSQNKLLEAQRLEQRTRFDMEMLREMGY
EECCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CQGIENYSMHLSGRKWGEKPNTLLDYFPEDFLTVIDESHVTVPQIRGMYNGDRARKDTLV
HCCCCCCEEEECCCCCCCCCCHHHHHCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHH
EYGFRLPSARENRPLRFDEFQESVNQVIYVSATPGRYELSRSQNIVEQIIRPTGLVDPEV
HHHCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEHHHHHHHHHHHHCCCCCCCCCC
RIRPVKGQVDDLLSEIRRRVERGERVLVTTLTKRMAEDLTDYYSRVGVKVRYLHSEIDTL
EEEECCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHH
ERVEIIDDLRRGEFDCLVGVNLLREGLDLPEVALVAILDADKEGFLRSETSLIQTIGRAA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHH
RNVNGEVLIYAGRFTDSVMAAVETTNRRRKLQMEYNRRHGIKPRSTRRTLREEEGPLRNL
HCCCCCEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
KVDEIPDHELELIIKDLEAEMRDAARNLEFERAARIRDRIMSLKSN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463