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Identifier: 15678276

GI number: 15678276

Start: 192458

End: 193156

Strand: Direct

Name: Not Available

Synonym: MTH248

Alternate gene names: 15678276

Gene position: 192458-193156 (Clockwise)

Preceding gene: 15678275

Following gene: 15678277

Centisome position: 10.99

GC content: 53.65

Gene sequence:

>699_bases
TTGATTAAGGTGATGGTTATGAAGATAGCAGTTATTGGTGGAACAGGAGACCAGGGCCTTGGACTGGCCCTGAGATTTGC
AGTAGCAGGTGAGGAAGTAATTATAGGTTCAAGAGACGCTGAGAAGGCATCTAAAGCAGCCTCAAAGGTCCTTGAGATAG
CTGGAAGGGATGACATCAGTGTTGAGGGTGCCACCAACCCTGATGCGGCAGCCTCTGCCGATGTGGTGGTGCTGACGGTT
CCCCTCCAGGCCCAGATGGTCACACTGGCCTCAATAAGGGATCAGGTGAGGGACAAGGTCCTCATAGATGCCACGGTACC
CATCGACAGCTGCATCGGCGGCTCAGCAGTCAGATACATTGACCTCTGGGAGGGTTCAGCGGCTGAGAGGGCTGCAAGGT
TCCTCAGGGAGCAGGGCACAAGGGTTGCAGCAGCCTTCAACAACATAAGCGCCTCCGCCCTCCTTGAAGTATCTGAGCCA
GTGGACTGTGACTGTCTGGTGGCATCAGACCACAGGGACGCCCTTGAAGTTGCAGCTGAACTTGCAGAGAAGATAGATGG
TGTCCGGGCCATTGAATGCGGCGGCCTTGAGAATGCAAGGATCATTGAGAAGATAACCCCGCTACTCATAAACCTCAACA
TAAGGAACAGGGTGAGGAATGCGGGCATAAGGATCACGAACCTTCCAGAGCAAGAGTAA

Upstream 100 bases:

>100_bases
ATATTCCGCTGGAGGGGTGCTGGTTTTCCAGGGAACTCTATCTGGGGTGTCAGCGCCCTGAAGGATTTCCCCTGGAGGGT
CAGGGTTTGAGATAATTTTA

Downstream 100 bases:

>100_bases
TCGCTGCAGTCATCCATGGAAGACCCCTTTAACAGATGCAGCCATACACAAGTACTGATTAAAGTTGATTGAAATGGAGA
TACTGAGGAATACTGTTCAG

Product: hypothetical protein

Products: NA

Alternate protein names: F420H2:NADP oxidoreductase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDISVEGATNPDAAASADVVVLTV
PLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYIDLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEP
VDCDCLVASDHRDALEVAAELAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE

Sequences:

>Translated_232_residues
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDISVEGATNPDAAASADVVVLTV
PLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYIDLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEP
VDCDCLVASDHRDALEVAAELAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE
>Mature_232_residues
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDISVEGATNPDAAASADVVVLTV
PLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYIDLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEP
VDCDCLVASDHRDALEVAAELAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE

Specific function: Catalyzes the reduction of NADP(+) with F420H(2) via hydride transfer, and the reverse reaction, i.e. the reduction of F420 with NADPH. Probably functions in the regeneration of NADPH required in biosynthetic reactions

COG id: COG2085

COG function: function code R; Predicted dinucleotide-binding enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent NADP reductase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FNO_METTH (O26350)

Other databases:

- EMBL:   AE000666
- PIR:   A69131
- RefSeq:   NP_275391.1
- ProteinModelPortal:   O26350
- SMR:   O26350
- STRING:   O26350
- GeneID:   1470209
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH248
- NMPDR:   fig|187420.1.peg.246
- eggNOG:   arNOG09739
- HOGENOM:   HBG692845
- OMA:   VVSAFHN
- ProtClustDB:   CLSK2460167
- BioCyc:   MTHE187420:MTH248-MONOMER
- GO:   GO:0005488
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR010185
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01915

Pfam domain/function: PF03807 F420_oxidored

EC number: NA

Molecular weight: Translated: 24539; Mature: 24539

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDIS
CEEEEEEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCE
VEGATNPDAAASADVVVLTVPLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYI
ECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCEEEEEEECCHHHCCCCCEEEEE
DLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEPVDCDCLVASDHRDALEVAAE
EECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHH
LAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE
HHHHHCCEEEEECCCCCCHHHHHHHCCEEEEEEHHHHHHHCCEEEECCCCCC
>Mature Secondary Structure
MIKVMVMKIAVIGGTGDQGLGLALRFAVAGEEVIIGSRDAEKASKAASKVLEIAGRDDIS
CEEEEEEEEEEEECCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCE
VEGATNPDAAASADVVVLTVPLQAQMVTLASIRDQVRDKVLIDATVPIDSCIGGSAVRYI
ECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCEEEEEEECCHHHCCCCCEEEEE
DLWEGSAAERAARFLREQGTRVAAAFNNISASALLEVSEPVDCDCLVASDHRDALEVAAE
EECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHH
LAEKIDGVRAIECGGLENARIIEKITPLLINLNIRNRVRNAGIRITNLPEQE
HHHHHCCEEEEECCCCCCHHHHHHHCCEEEEEEHHHHHHHCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463