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Identifier: 15678260

GI number: 15678260

Start: 174369

End: 175136

Strand: Direct

Name: Not Available

Synonym: MTH232

Alternate gene names: 15678260

Gene position: 174369-175136 (Clockwise)

Preceding gene: 15678259

Following gene: 15678261

Centisome position: 9.96

GC content: 49.74

Gene sequence:

>768_bases
ATGTCACCATTAAAGCCCCTTTACAAGCTGTACGAATGGTACATATCGCGCAACCTCAGAAGGGACAGAATGCCAAGACA
TGTTGCCATCATCATGGATGGTAACAGGAGATACTCAAAGCTGCAGGGCAGTATGAACCCCATAGAAGGCCATAAGAAGG
GCATAGAAACCCTCGAGAAGGTCCTGGACTGGTGCGTGGACCTCGGGATAGAAATAGTAACGGCGTACGCCTTCTCAACA
GAGAACTTCAAGAGACCAGAAAAGGAGGTTAAGGGTCTCATGAAGCTCTTCAGGGAAAACTTCGAGGCCATAGCAAGCAA
TGAGAAGATACATAAGAACAGGGTCAGGGTCAGAGCAGTCGGAAAACTTGAACTCCTCCCGGAGGACGTCAGAAGGGCCA
TAGAGATCGCTGAGAAGTCAACAGAGCAGTACTCAGACCGCCTTGTGAACATAGCCATAGGATATGATGGAAGGCAGGAG
ATAGTTGACGCCACAAGAAAGATTGCAGAGGATGTTAAGGCGGGTTTGATAGACCCGGAGGACATAGACGAGGACATGAT
AAACAGAAACCTCTACACTGCAGGTCTGGAGGACCCGCACCTGATAATAAGGACCAGTGGCGAGGAAAGACTCAGTGGCT
TCCTGCTCTGGCAGTCATCCTACTCTGAACTCTACTTCTGCGACAGCCTGTGGCCTGAACTCAGGAAGGTAGACTTTTTA
AGGGCCATAAGGTCATATCAGCAGCGTGAGAGAAGGTTCGGCGTCTAG

Upstream 100 bases:

>100_bases
GGATGGAATGAAGATAATGAATAATAGGACCGTTAATCGTATTAATTAAATTAATATTAACTGACCGGATGAACAAAAAT
TATGATCAGGTAGATTTGAA

Downstream 100 bases:

>100_bases
CACAGCCCCTTGATTCATGGGAGGTATGTAGACGTTATCCATATCAATCACTGATTATGGGAGGTATCATCATTATAGAC
GTTCACTGTCACCTTGACTT

Product: hypothetical protein

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSPLKPLYKLYEWYISRNLRRDRMPRHVAIIMDGNRRYSKLQGSMNPIEGHKKGIETLEKVLDWCVDLGIEIVTAYAFST
ENFKRPEKEVKGLMKLFRENFEAIASNEKIHKNRVRVRAVGKLELLPEDVRRAIEIAEKSTEQYSDRLVNIAIGYDGRQE
IVDATRKIAEDVKAGLIDPEDIDEDMINRNLYTAGLEDPHLIIRTSGEERLSGFLLWQSSYSELYFCDSLWPELRKVDFL
RAIRSYQQRERRFGV

Sequences:

>Translated_255_residues
MSPLKPLYKLYEWYISRNLRRDRMPRHVAIIMDGNRRYSKLQGSMNPIEGHKKGIETLEKVLDWCVDLGIEIVTAYAFST
ENFKRPEKEVKGLMKLFRENFEAIASNEKIHKNRVRVRAVGKLELLPEDVRRAIEIAEKSTEQYSDRLVNIAIGYDGRQE
IVDATRKIAEDVKAGLIDPEDIDEDMINRNLYTAGLEDPHLIIRTSGEERLSGFLLWQSSYSELYFCDSLWPELRKVDFL
RAIRSYQQRERRFGV
>Mature_254_residues
SPLKPLYKLYEWYISRNLRRDRMPRHVAIIMDGNRRYSKLQGSMNPIEGHKKGIETLEKVLDWCVDLGIEIVTAYAFSTE
NFKRPEKEVKGLMKLFRENFEAIASNEKIHKNRVRVRAVGKLELLPEDVRRAIEIAEKSTEQYSDRLVNIAIGYDGRQEI
VDATRKIAEDVKAGLIDPEDIDEDMINRNLYTAGLEDPHLIIRTSGEERLSGFLLWQSSYSELYFCDSLWPELRKVDFLR
AIRSYQQRERRFGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=43.9330543933054, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=43.9330543933054, Blast_Score=205, Evalue=3e-53,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=42.6086956521739, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=239, Percent_Identity=41.4225941422594, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319474, Length=224, Percent_Identity=38.8392857142857, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=264, Percent_Identity=32.9545454545455, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=42.0353982300885, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_METTH (O26334)

Other databases:

- EMBL:   AE000666
- PIR:   H69128
- RefSeq:   NP_275375.1
- ProteinModelPortal:   O26334
- SMR:   O26334
- STRING:   O26334
- GeneID:   1470193
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH232
- NMPDR:   fig|187420.1.peg.230
- eggNOG:   arNOG04581
- HOGENOM:   HBG627837
- OMA:   YGGQQEI
- PhylomeDB:   O26334
- ProtClustDB:   CLSK797868
- BioCyc:   MTHE187420:MTH232-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29901; Mature: 29769

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 33-33

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLKPLYKLYEWYISRNLRRDRMPRHVAIIMDGNRRYSKLQGSMNPIEGHKKGIETLEK
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHH
VLDWCVDLGIEIVTAYAFSTENFKRPEKEVKGLMKLFRENFEAIASNEKIHKNRVRVRAV
HHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEC
GKLELLPEDVRRAIEIAEKSTEQYSDRLVNIAIGYDGRQEIVDATRKIAEDVKAGLIDPE
CHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
DIDEDMINRNLYTAGLEDPHLIIRTSGEERLSGFLLWQSSYSELYFCDSLWPELRKVDFL
HCCHHHHCCCCEECCCCCCEEEEEECCHHHHHEEEEEECCCCCEEEHHHHHHHHHHHHHH
RAIRSYQQRERRFGV
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPLKPLYKLYEWYISRNLRRDRMPRHVAIIMDGNRRYSKLQGSMNPIEGHKKGIETLEK
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHH
VLDWCVDLGIEIVTAYAFSTENFKRPEKEVKGLMKLFRENFEAIASNEKIHKNRVRVRAV
HHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEC
GKLELLPEDVRRAIEIAEKSTEQYSDRLVNIAIGYDGRQEIVDATRKIAEDVKAGLIDPE
CHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
DIDEDMINRNLYTAGLEDPHLIIRTSGEERLSGFLLWQSSYSELYFCDSLWPELRKVDFL
HCCHHHHCCCCEECCCCCCEEEEEECCHHHHHEEEEEECCCCCEEEHHHHHHHHHHHHHH
RAIRSYQQRERRFGV
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463