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The map label for this gene is hisD

Identifier: 15678253

GI number: 15678253

Start: 167298

End: 168578

Strand: Direct

Name: hisD

Synonym: MTH225

Alternate gene names: 15678253

Gene position: 167298-168578 (Clockwise)

Preceding gene: 15678239

Following gene: 15678254

Centisome position: 9.55

GC content: 54.02

Gene sequence:

>1281_bases
ATGCTGATGAAGATAACAGAATTTGATTACAGACGGATTTCTGAACTCGTTGAAAGAGCAAGGCTTGACGTCGATGATGT
CCTTGGACCCGTGGCAGACATCATATCCATGGTGAGGGATGGAGGTGACGATGCCCTCAGGGAACTCACAGGGAGATTCG
ATGGAGTGACCGTTGAGAACTTCAGGGTCAGCAGGGAGGAGATAGAGGAGGCCCACAAAAACCTTGAACCCGGGGTGAAG
GAGGCACTCAGGGAAGCCGCCAGCAACATTGAGGAATTCCACAGGATGCAGATGCCCTCAGGCTGGATGTCTGAGGTTAG
ACCCGGGGTCATGGCCGGCCAGCTGGTGCGCCCCATTGACAGTGTGGGCTGCTACATACCGGGTGGAAGGGCTGTGTACC
CCTCAACGATACTCATGACCGTGATACCTGCAAGGATAGCAGGTGTTGAGAGGATAGTATGCTGCACCCCGCCGGCACAG
GACGGCTCGGTACCCGACGCGGTTCTTGTGGCAGCCGACATGGCAGGGGCCAGTGAAATATACCGTGTTGGGGGAGCACA
GGCCGTTGCAGCGATGGCCTACGGCACAGAGACCATCAGGCCCGTTGATAAAATCGTTGGACCTGGCAACATATTTGTAA
CCGCTGCAAAGAAACTGGTCTACGGTGAAGTGGACATAGACTTCCCTGCAGGACCCTCAGAGGTCCTTATAATCGCCGAT
GAAACTGCCAGTCCAGAGTACATCGCCCTCGAAATACTTGCACAGGCAGAACACGACCCCCAGGCTGCAAGCGTCCTTGT
CACAGACTCCAGGGACCTTGCCCTTGAGGTGAAGGAGATGGTCCATGAAAACATTAAATACATGGAAAGGGCCAATATCA
TAAGGGAGTCCCTTGAAAGGTACGGGATGATAGTTTTAACAGCTGATATTGATGAGGCTGTGGACTTCAGCAATGCATAC
GCCCCCGAGCACCTTGTTATAATGACGGATTCTCCAGAAGAAACATTGGAGGGCATCCGTAACGCGGGATCCATATTCCT
GGGGGAACTGTCCCCTGTGGCTGCAGGGGATTACGGTTCAGGCACAAACCATGTGCTGCCAACCTCGGGATGCGCAAGGA
TGTACTCGGGTCTCTCCACAGAATCCTTCATCAAAAAACCAACAGTCCAGAGGATAACCAAGGAGGGCCTCAGAAACCTC
CAGGGCACCGTCCTGAAACTTGCAGAGTACGAGGGCCTCCATGCCCATGCTGAATCCTTCAGGAGGAGGCTGAGGGACTG
A

Upstream 100 bases:

>100_bases
GAATTCTTCAAATTATTAAATGATCCGGTGTGCCCCCTAAATTCTTAAAAGGGAATGGCTCCATAAAACTAACCATTCGC
CCTAACTTTTTCACTGGAGG

Downstream 100 bases:

>100_bases
TTGATGAAGGCAGATTAATCTGCTGAACTCTGATAATGCATGGTTTCATCAGAGACCTTAAATATTCACTTTAAACTGTT
AGAGGTGATTTGATTGTTAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLMKITEFDYRRISELVERARLDVDDVLGPVADIISMVRDGGDDALRELTGRFDGVTVENFRVSREEIEEAHKNLEPGVK
EALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPIDSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQ
DGSVPDAVLVAADMAGASEIYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVDIDFPAGPSEVLIIAD
ETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRESLERYGMIVLTADIDEAVDFSNAY
APEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGDYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNL
QGTVLKLAEYEGLHAHAESFRRRLRD

Sequences:

>Translated_426_residues
MLMKITEFDYRRISELVERARLDVDDVLGPVADIISMVRDGGDDALRELTGRFDGVTVENFRVSREEIEEAHKNLEPGVK
EALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPIDSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQ
DGSVPDAVLVAADMAGASEIYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVDIDFPAGPSEVLIIAD
ETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRESLERYGMIVLTADIDEAVDFSNAY
APEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGDYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNL
QGTVLKLAEYEGLHAHAESFRRRLRD
>Mature_426_residues
MLMKITEFDYRRISELVERARLDVDDVLGPVADIISMVRDGGDDALRELTGRFDGVTVENFRVSREEIEEAHKNLEPGVK
EALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPIDSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQ
DGSVPDAVLVAADMAGASEIYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVDIDFPAGPSEVLIIAD
ETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRESLERYGMIVLTADIDEAVDFSNAY
APEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGDYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNL
QGTVLKLAEYEGLHAHAESFRRRLRD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=397, Percent_Identity=45.5919395465995, Blast_Score=340, Evalue=9e-95,
Organism=Saccharomyces cerevisiae, GI6319819, Length=407, Percent_Identity=44.7174447174447, Blast_Score=323, Evalue=5e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_METTH (O26327)

Other databases:

- EMBL:   AE000666
- PIR:   H69127
- RefSeq:   NP_275368.1
- ProteinModelPortal:   O26327
- SMR:   O26327
- STRING:   O26327
- GeneID:   1470186
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH225
- NMPDR:   fig|187420.1.peg.223
- eggNOG:   arNOG04971
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   O26327
- ProtClustDB:   PRK00877
- BioCyc:   MTHE187420:MTH225-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46420; Mature: 46420

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 323-323 ACT_SITE 324-324 BINDING 125-125 BINDING 187-187 BINDING 210-210 BINDING 233-233 BINDING 255-255 BINDING 258-258 BINDING 324-324 BINDING 357-357 BINDING 411-411 BINDING 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKITEFDYRRISELVERARLDVDDVLGPVADIISMVRDGGDDALRELTGRFDGVTVEN
CCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHH
FRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPID
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCHH
SVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASEI
HCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHEEEHHHCCHHHH
YRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVDIDFPAGPSEVLIIAD
HHCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHHHEEEEEEECCCCCCCCEEEEEE
ETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRESLER
CCCCCCEEEHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGDYGS
CCEEEEEECCHHHHCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCC
GTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAHAESF
CCCCCCCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RRRLRD
HHHHCC
>Mature Secondary Structure
MLMKITEFDYRRISELVERARLDVDDVLGPVADIISMVRDGGDDALRELTGRFDGVTVEN
CCEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEHH
FRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPID
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHCCHH
SVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASEI
HCCCCCCCCCEECHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHEEEHHHCCHHHH
YRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVDIDFPAGPSEVLIIAD
HHCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEHHHHEEEEEEECCCCCCCCEEEEEE
ETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRESLER
CCCCCCEEEHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGDYGS
CCEEEEEECCHHHHCCCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEECCCCCCCCCCCC
GTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAHAESF
CCCCCCCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RRRLRD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463