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Identifier: 15678218

GI number: 15678218

Start: 134383

End: 134961

Strand: Direct

Name: Not Available

Synonym: MTH190

Alternate gene names: 15678218

Gene position: 134383-134961 (Clockwise)

Preceding gene: 15678217

Following gene: 15678219

Centisome position: 7.67

GC content: 47.5

Gene sequence:

>579_bases
ATGATAAGGATAGGTATTCTTGCTCTTCAGGGAGATGTATCCGAACACCTCGAGATGACCAGAAGGACAGTCGAAGAGAT
GGGCATAGATGCAGAGGTTGTGAGGGTCAGGACAGCAGAGGAAGCCTCCACAGTCGATGCAATAATAATATCCGGCGGCG
AGAGTACGGTAATAGGTAGGCTGATGGAGGAGACAGGGATAAAGGACGTCATAATCCGCGAAAAGAAACCTGTGATGGGC
ACATGTGCCGGCATGGTGCTCCTTGCAGATGAAACAGATTATGAACAGCCCCTTCTGGGACTCATAGATATGAAGGTTAA
GAGAAACGCCTTTGGAAGACAGAGAGACTCCTTTGAAGATGAGATCGATATACTTGGAAGGAAATTTCATGGAATATTCA
TAAGGGCGCCGGCTGTCCTTGAAGTGGGAGAGGGAGTTGAGGTTCTCTCAGAACTCGATGATATGATAATCGCAGTAAAG
GACGGCTGCAACCTCGCACTGGCCTTTCACCCTGAACTCGGAGAGGACACAGGACTCCATGAATACTTTATAAAGGAGGT
ATTGAATTGTGTGGAATAG

Upstream 100 bases:

>100_bases
AGGGTTCAGGGTTCAGAAACAACCGGCAGACATCTTCCGGTATATTTATATGGTCACATCATGAAAAAGGTAACCAGAAA
AAATTCTCAAAGGAGACACC

Downstream 100 bases:

>100_bases
CGGGAGTGGTCTACAAGGATGGTAAACTGCACTCAGTCGGGGCAGACATGACAAGGATGCTCCATGCACTGCAGCACAGG
GGACCAGACTCAGCAGGATT

Product: glutamine amidotransferase subunit PdxT

Products: NA

Alternate protein names: Glutamine amidotransferase glutaminase subunit pdxT

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGRLMEETGIKDVIIREKKPVMG
TCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFEDEIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVK
DGCNLALAFHPELGEDTGLHEYFIKEVLNCVE

Sequences:

>Translated_192_residues
MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGRLMEETGIKDVIIREKKPVMG
TCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFEDEIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVK
DGCNLALAFHPELGEDTGLHEYFIKEVLNCVE
>Mature_192_residues
MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGRLMEETGIKDVIIREKKPVMG
TCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFEDEIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVK
DGCNLALAFHPELGEDTGLHEYFIKEVLNCVE

Specific function: Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to pdxS

COG id: COG0311

COG function: function code H; Predicted glutamine amidotransferase involved in pyridoxine biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine amidotransferase pdxT/SNO family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323742, Length=208, Percent_Identity=36.0576923076923, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323995, Length=212, Percent_Identity=37.7358490566038, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321048, Length=212, Percent_Identity=37.2641509433962, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXT_METTH (O26292)

Other databases:

- EMBL:   AE000666
- PIR:   F69120
- RefSeq:   NP_275333.1
- ProteinModelPortal:   O26292
- SMR:   O26292
- STRING:   O26292
- GeneID:   1470151
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH190
- NMPDR:   fig|187420.1.peg.188
- eggNOG:   arNOG08412
- HOGENOM:   HBG292341
- OMA:   QGDVREH
- PhylomeDB:   O26292
- ProtClustDB:   PRK13527
- BioCyc:   MTHE187420:MTH190-MONOMER
- HAMAP:   MF_01615
- InterPro:   IPR002161
- PIRSF:   PIRSF005639
- TIGRFAMs:   TIGR03800

Pfam domain/function: PF01174 SNO

EC number: NA

Molecular weight: Translated: 21215; Mature: 21215

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS01236 PDXT_SNO_1; PS51130 PDXT_SNO_2

Important sites: ACT_SITE 82-82 ACT_SITE 170-170 ACT_SITE 172-172 BINDING 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGR
CEEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEEEEECCCHHHHHH
LMEETGIKDVIIREKKPVMGTCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFED
HHHHCCCCEEEEECCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVKDGCNLALAFHPELGEDTGLH
HHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCHH
EYFIKEVLNCVE
HHHHHHHHHHCC
>Mature Secondary Structure
MIRIGILALQGDVSEHLEMTRRTVEEMGIDAEVVRVRTAEEASTVDAIIISGGESTVIGR
CEEEEEEEEECCHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCEEEEEEECCCHHHHHH
LMEETGIKDVIIREKKPVMGTCAGMVLLADETDYEQPLLGLIDMKVKRNAFGRQRDSFED
HHHHCCCCEEEEECCCCCEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
EIDILGRKFHGIFIRAPAVLEVGEGVEVLSELDDMIIAVKDGCNLALAFHPELGEDTGLH
HHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHEEEEEECCCEEEEEECCCCCCCCCHH
EYFIKEVLNCVE
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463